N-(3-methoxy-4,5-methylenedioxycinnamoyl)piperidine | 1415037-22-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: N-(3-methoxy-4,5-methylenedioxycinnamoyl)piperidine
• 英文别名: (E)-3-(7-methoxy-1,3-benzodioxol-5-yl)-1-piperidin-1-ylprop-2-en-1-one
• CAS: 1415037-22-7
• 化学式: C₁₆H₁₉NO₄
• 分子量: 289.331
• InChiKey: JJAUBODXTTWHQD-AATRIKPKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  48
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3,4-methylenedioxy-trans-cinnamic acid 在 盐酸 、 硫酸 、 硝酸 、 二甲基氯化铝 、 tin(ll) chloride 、 sodium nitrite 作用下， 以 四氢呋喃 、 乙醇 、 水 、 溶剂黄146 为溶剂， 反应 17.0h， 生成 N-(3-methoxy-4,5-methylenedioxycinnamoyl)piperidine
  参考文献：
  名称：

  Synthesis, characterization, antidepressant and antioxidant activity of novel piperamides bearing piperidine and piperazine analogues

  摘要：

  A series of piperamide derivatives (8a-j) was synthesized with various substituted piperidine and piperazine compounds. The prepared compounds were evaluated for antibacterial activity against gram-positive and gram-negative bacteria and antifungal activity by disc diffusion method. The antioxidant activity of the compounds was evaluated by DPPH and superoxide radical scavenging method and antidepressant activity using forced swim and tail suspension behavioral despair tests in mice. The compounds 8a, 8b and 8c were investigated for their monoamine oxidase A and B (MAO-A and MAO-B) inhibitory property. Some of the test compounds were active in forced swim test (FST) and tail suspension test (TST). Compounds 8a and 8b showed a significant effect, when compared to standard drug, clorgyline. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.09.089

文献信息

• COMPOSITIONS COMPRISING EXTRACTS OF APLINIA AND OTHER PLANTS FOR IMPROVING JOINT HEALTH AND TREATING ARTHRITIS
  申请人：Unigen, Inc.

  公开号：EP4100034A1

  公开（公告）日：2022-12-14
• Compositions and Methods for Regulating Homeostasis of Chondrocytes, Extracellular Matrix, Articular Cartilage, and Phenotype of Arthritis
  申请人：Unigen, Inc.

  公开号：US20220000964A1

  公开（公告）日：2022-01-06

  Medicinal plant extracts and their bioactives from Alpinia, Magnolia, Kochia and Piper /Pepper are disclosed herein in combination or alone in regulating homeostasis of chondrocytes, extracellular matrix, articular cartilage, and phenotype of arthritis that lead to enhanced anabolic functions of chondrocytes, increased renewal/rebuilding/regeneration of extracellular matrix and articular cartilage, and improved phenotype of osteoarthritis and rheumatoid arthritis.
• [EN] COMPOSITIONS COMPRISING EXTRACTS OF APLINIA AND OTHER PLANTS FOR IMPROVING JOINT HEALTH AND TREATING ARTHRITIS<br/>[FR] COMPOSITIONS COMPRENANT DES EXTRAITS D'APLINIA ET D'AUTRES PLANTES POUR AMÉLIORER LA SANTÉ ARTICULAIRE ET TRAITER L'ARTHRITE
  申请人：UNIGEN INC

  公开号：WO2021159042A1

  公开（公告）日：2021-08-12

  Medicinal plant extracts and their bioactives from Alpinia, Magnolia, Kochia and Piper/Pepper are disclosed herein in combination or alone in regulating homeostasis of chondrocytes, extracellular matrix, articular cartilage, and phenotype of arthritis that lead to enhanced anabolic functions of chondrocytes, increased renewal/rebuilding/regeneration of extracellular matrix and articular cartilage, and improved phenotype of osteoarthritis and rheumatoid arthritis.
• Synthesis, characterization, antidepressant and antioxidant activity of novel piperamides bearing piperidine and piperazine analogues
  作者：M.K. Prashanth、Hosakere D. Revanasiddappa、K.M. Lokanatha Rai、B. Veeresh

  DOI：10.1016/j.bmcl.2012.09.089

  日期：2012.12

  A series of piperamide derivatives (8a-j) was synthesized with various substituted piperidine and piperazine compounds. The prepared compounds were evaluated for antibacterial activity against gram-positive and gram-negative bacteria and antifungal activity by disc diffusion method. The antioxidant activity of the compounds was evaluated by DPPH and superoxide radical scavenging method and antidepressant activity using forced swim and tail suspension behavioral despair tests in mice. The compounds 8a, 8b and 8c were investigated for their monoamine oxidase A and B (MAO-A and MAO-B) inhibitory property. Some of the test compounds were active in forced swim test (FST) and tail suspension test (TST). Compounds 8a and 8b showed a significant effect, when compared to standard drug, clorgyline. (C) 2012 Elsevier Ltd. All rights reserved.