3-十二烷基苯甲醛 | 307498-21-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3-十二烷基苯甲醛
• 英文名称: 3-dodecylbenzaldehyde
• 英文别名: 3-Dodecylbenzaldehyde
• CAS: 307498-21-1
• 化学式: C₁₉H₃₀O
• 分子量: 274.447
• InChiKey: ZZFKTLFANQRCAU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.6
• 重原子数：
  20
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-十二烷基苯甲醛 在 三氟乙酸 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 为溶剂， 生成 3-(3-Dodecylphenyl)-3-hydroxypropanoic acid
  参考文献：
  名称：

  Syntheses and antifungal activity of pseudomycin side-chain analogues. Part 1

  摘要：

  We have described herein the syntheses of three novel series of aromatic ring containing pseudomycin side-chain analogues. Preliminary biological evaluations of these analogues clearly indicate that it is possible to synthesize rigid pseudomycin sidechain analogues without compromising in vitro antifungal activity. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00423-6
• 作为产物：
  描述：

  间溴苯甲醛 在 palladium/alumina copper(l) iodide 、 TEA 、 氢气 、 三苯基膦 、 palladium dichloride 作用下， 以 乙酸乙酯 、 乙腈 为溶剂， 生成 3-十二烷基苯甲醛
  参考文献：
  名称：

  Syntheses and antifungal activity of pseudomycin side-chain analogues. Part 1

  摘要：

  We have described herein the syntheses of three novel series of aromatic ring containing pseudomycin side-chain analogues. Preliminary biological evaluations of these analogues clearly indicate that it is possible to synthesize rigid pseudomycin sidechain analogues without compromising in vitro antifungal activity. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00423-6

文献信息

• LONG CHAIN BASE SPHINGOSINE KINASE INHIBITORS
  申请人：UNIVERSITY OF VIRGINIA PATENT FOUNDATION

  公开号：US20150210675A1

  公开（公告）日：2015-07-30

  The invention relates to inhibitors of Sphingosine Kinase enzymatic activity, and methods of treating diseases and disorders by administering inhibitors of Sphingosine Kinase enzymatic activity.

  本发明涉及抑制鞘氨醇激酶酶活性的抑制剂，以及通过给予鞘氨醇激酶酶活性抑制剂治疗疾病和疾患的方法。
• Buckminsterfullerene derivatives bearing a fluoroalkyl group for use in organic photovoltaic cells
  作者：Makoto Karakawa、Takabumi Nagai、Tomomi Irita、Kenji Adachi、Yutaka Ie、Yoshio Aso

  DOI：10.1016/j.jfluchem.2012.09.009

  日期：2012.12

  Six novel fluoroalkylpyrrolidine-substituted [60]fullerene derivatives were synthesized and their ability to perform as new n-type organic photovoltaic materials was evaluated. The fullerene derivatives were soluble in common organic solvents, affording good processability properties for the fabrication of photovoltaic cells, and showed an absorption range and molar extinctions similar to those of 16,6]-phenyl C-61 butyric acid methyl ester. Bulk-heterojunction photovoltaic cells using poly(3-hexylthiophene):fullerene derivative blends as the photovoltaic active layers were fabricated and characterized. The performances of the photovoltaic cells were notably affected by the substituents on the fullerene derivatives. Short fluoroalkyl (C4F9) chains on pyrrolidine-linked phenyl groups were suitable substituents for the photovoltaic materials in the current study. This fullerene derivative bearing a C4F9-phenyl group showed a moderate power conversion efficiency of 0.53% during simulated AM 1.5 G solar irradiation at 100 mW/cm(2). This is so far the first report of the use of fluoroalkyl fullerene derivatives as the active materials in organic photovoltaic cells. (C) 2012 Elsevier B.V. All rights reserved.
• PSEUDOMYCIN N-ACYL SIDE-CHAIN ANALOGS
  申请人：ELI LILLY AND COMPANY

  公开号：EP1200460A1

  公开（公告）日：2002-05-02
• US9688668B2
  申请人：——

  公开号：US9688668B2

  公开（公告）日：2017-06-27
• [EN] PSEUDOMYCIN N-ACYL SIDE-CHAIN ANALOGS<br/>[FR] ANALOGUES A BASE DE PSEUDOMYCINE A CHAINES LATERALES N-ACYLE
  申请人：LILLY CO ELI

  公开号：WO2001005814A1

  公开（公告）日：2001-01-25

  Semi-synthetic pseudomycin compounds having structure (I) are described which may be useful as antifungal agents or intermediates in the design of antifungal agents.