2-[hexadecyl-[2-[(1R,4S,5R,8S,9R,10R,12R,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-yl]acetyl]amino]acetic acid | 1218923-45-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 2-[hexadecyl-[2-[(1R,4S,5R,8S,9R,10R,12R,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-yl]acetyl]amino]acetic acid
• CAS: 1218923-45-5
• 化学式: C₃₅H₆₁NO₇
• 分子量: 607.872
• InChiKey: NTOIHVANZIKUDF-NJZZKQGSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.9
• 重原子数：
  43
• 可旋转键数：
  19
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  94.5
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  在 ruthenium trichloride 、 sodium periodate 、 碳酸氢钠 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 1.0h， 以60%的产率得到2-[hexadecyl-[2-[(1R,4S,5R,8S,9R,10R,12R,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-yl]acetyl]amino]acetic acid
  参考文献：
  名称：

  Subcellular Localization of a Fluorescent Artemisinin Derivative to Endoplasmic Reticulum

  摘要：

  A cytotoxic artemisinin derivative conjugated with a fluorescent dansyl moiety was synthesized and its subcellular localization in Hep3B cells was examined. Comparison of the localization signals of the fluorescent artemisinin derivative with organelle specific dyes revealed that endoplasmic reticulum (ER) is the main site of its accumulation.

  DOI：

  10.1021/ol902890j

文献信息

• Subcellular Localization of a Fluorescent Artemisinin Derivative to Endoplasmic Reticulum
  作者：Yungen Liu、Chun-Nam Lok、Ben Chi-Bun Ko、Tina Yuen-Ting Shum、Man-Kin Wong、Chi-Ming Che

  DOI：10.1021/ol902890j

  日期：2010.4.2

  A cytotoxic artemisinin derivative conjugated with a fluorescent dansyl moiety was synthesized and its subcellular localization in Hep3B cells was examined. Comparison of the localization signals of the fluorescent artemisinin derivative with organelle specific dyes revealed that endoplasmic reticulum (ER) is the main site of its accumulation.