4',8-dihydroxyisoflavon-7-yl 2,3,4,6-tetra-O-acetyl-β-D-galactopyranoside | 331718-42-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异黄酮类化合物
• 英文名称: 4',8-dihydroxyisoflavon-7-yl 2,3,4,6-tetra-O-acetyl-β-D-galactopyranoside
• 英文别名: [(2R,3S,4S,5R,6S)-3,4,5-triacetyloxy-6-[8-hydroxy-3-(4-hydroxyphenyl)-4-oxochromen-7-yl]oxyoxan-2-yl]methyl acetate
• CAS: 331718-42-4
• 化学式: C₂₉H₂₈O₁₄
• 分子量: 600.533
• InChiKey: UUKZNCJWYXXSAQ-VUGKQVTMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  43
• 可旋转键数：
  12
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.34
• 拓扑面积：
  190
• 氢给体数：
  2
• 氢受体数：
  14

反应信息

• 作为反应物：
  描述：

  4',8-dihydroxyisoflavon-7-yl 2,3,4,6-tetra-O-acetyl-β-D-galactopyranoside 在 氢氧化钾 作用下， 以 乙醇 为溶剂， 反应 4.0h， 以100%的产率得到4',8-dihydroxyisoflavon-7-yl β-D-galactopyranoside
  参考文献：
  名称：

  Synthesis and biological activity of 4′,8-dihydroxyisoflavon-7-yl d-hexopyranosides

  摘要：

  Four 4 ' ,8-dihydroxyisoflavon-7-yl hexopyranoside derivatives having an aglycon part of A-76202 were synthesized, and their biological activities were evaluated toward rat liver alpha -glucosidase. However, the activities were disappointing. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0008-6215(01)00246-4
• 作为产物：
  描述：

  4',8-diallyloxy-7-hydroxyisoflavone 在 rhodium(III) chloride 、 silver carbonate 作用下， 以 吡啶 、 乙醇 为溶剂， 反应 22.5h， 生成 4',8-dihydroxyisoflavon-7-yl 2,3,4,6-tetra-O-acetyl-β-D-galactopyranoside
  参考文献：
  名称：

  Synthesis and biological activity of 4′,8-dihydroxyisoflavon-7-yl d-hexopyranosides

  摘要：

  Four 4 ' ,8-dihydroxyisoflavon-7-yl hexopyranoside derivatives having an aglycon part of A-76202 were synthesized, and their biological activities were evaluated toward rat liver alpha -glucosidase. However, the activities were disappointing. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0008-6215(01)00246-4