(2S,3S,4S,5R,6S)-4,5-bis(benzoyloxy)-3-((4-methoxybenzyl)oxy)-6-(phenylthio)tetrahydro-2H-pyran-2-carboxylic acid | 1287768-50-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2S,3S,4S,5R,6S)-4,5-bis(benzoyloxy)-3-((4-methoxybenzyl)oxy)-6-(phenylthio)tetrahydro-2H-pyran-2-carboxylic acid
• CAS: 1287768-50-6
• 化学式: C₃₄H₃₀O₉S
• 分子量: 614.673
• InChiKey: DLQTYVMNDOSPMX-ZNKNSDIESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.63
• 重原子数：
  44.0
• 可旋转键数：
  11.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  117.59
• 氢给体数：
  1.0
• 氢受体数：
  9.0

反应信息

• 作为反应物：
  描述：

  (2S,3S,4S,5R,6S)-4,5-bis(benzoyloxy)-3-((4-methoxybenzyl)oxy)-6-(phenylthio)tetrahydro-2H-pyran-2-carboxylic acid 在 吡啶 、 盐酸 、 4-二甲氨基吡啶 、 N-碘代丁二酰亚胺 、 copper(l) iodide 、 叠氮基三甲基硅烷 、 palladium 10% on activated carbon 、 氢气 、 四氯化锡 、 caesium carbonate 、 溶剂黄146 、 N,N-二异丙基乙胺 作用下， 以 甲醇 、 二氯甲烷 、 乙酸乙酯 、 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 57.0h， 生成 methyl (2S,3S,4S,5R,6R)-6-[4-[[(2R,3S,4R,5R,6R)-5-acetamido-4-acetyloxy-2-(acetyloxymethyl)-6-azidooxan-3-yl]oxymethyl]triazol-1-yl]-4,5-dibenzoyloxy-3-hydroxyoxane-2-carboxylate
  参考文献：
  名称：

  Design and Synthesis of Unnatural Heparosan and Chondroitin Building Blocks

  摘要：

  Triazole linked heparosan and chondroitin disaccharide and tetrasaccharide building blocks were synthesized in a stereoselective manner by applying a very efficient copper catalyzed azide-alkyne cycloaddition (CuAAC) reaction of appropriately substituted azido-glucuronic acid and propargyluted N-acetyl glucosamine and N-acetyl galactosamine derivative, respectively. The resulting suitably substituted tetrasaccharide analogues can be easily converted into azide and alkyne unit for further synthesis of higher oligosaccharide analogues.

  DOI：

  10.1021/jo200076z
• 作为产物：
  描述：

  phenyl 2,3-di-O-benzoyl-4-O-p-methoxybenzyl-1-thio-β-D-glucopyranoside 在 2,2,6,6-四甲基哌啶氧化物 、 碘苯二乙酸 作用下， 以 二氯甲烷 、 水 为溶剂， 生成 (2S,3S,4S,5R,6S)-4,5-bis(benzoyloxy)-3-((4-methoxybenzyl)oxy)-6-(phenylthio)tetrahydro-2H-pyran-2-carboxylic acid
  参考文献：
  名称：

  Design and Synthesis of Unnatural Heparosan and Chondroitin Building Blocks

  摘要：

  Triazole linked heparosan and chondroitin disaccharide and tetrasaccharide building blocks were synthesized in a stereoselective manner by applying a very efficient copper catalyzed azide-alkyne cycloaddition (CuAAC) reaction of appropriately substituted azido-glucuronic acid and propargyluted N-acetyl glucosamine and N-acetyl galactosamine derivative, respectively. The resulting suitably substituted tetrasaccharide analogues can be easily converted into azide and alkyne unit for further synthesis of higher oligosaccharide analogues.

  DOI：

  10.1021/jo200076z