(4E,6E)-1,9-Bis-(tert-butyl-dimethyl-silanyloxy)-10-(4-methoxy-benzyloxy)-6-methyl-deca-4,6-dien-3-ol | 444809-47-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (4E,6E)-1,9-Bis-(tert-butyl-dimethyl-silanyloxy)-10-(4-methoxy-benzyloxy)-6-methyl-deca-4,6-dien-3-ol
• CAS: 444809-47-6
• 化学式: C₃₁H₅₆O₅Si₂
• 分子量: 564.954
• InChiKey: YHZHCKOCURCTLQ-DONFXTHASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.27
• 重原子数：
  38.0
• 可旋转键数：
  15.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  57.15
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  乙烯基乙醚 、 (4E,6E)-1,9-Bis-(tert-butyl-dimethyl-silanyloxy)-10-(4-methoxy-benzyloxy)-6-methyl-deca-4,6-dien-3-ol 在 4-甲基苯磺酸吡啶 作用下， 以85%的产率得到1-[(4E,6E)-2,10-Bis-(tert-butyl-dimethyl-silanyloxy)-8-(2-ethoxy-ethoxy)-5-methyl-deca-4,6-dienyloxymethyl]-4-methoxy-benzene
  参考文献：
  名称：

  A study toward a total synthesis of fostriecin

  摘要：

  In order to synthesize the major C(3)-C(12) part of fostriecin, asymmetric dihydroxylation of several dienes 5a-f, prepared by cross-coupling reactions of several types. vas studied, thus providing high dependency on the hydroxyl groups at C(5) and C(l 1). The best regioselectivity was obtained with 5d to produce diol 23. which was later transformed into the advanced intermediate 26. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)00403-3
• 作为产物：
  描述：

  1-(4-methoxybenzyloxy)-5-trimethylsilanylpent-4-ol 在 双(乙腈)氯化钯(II) 、 正丁基锂 、 二氯二茂锆 、 二异丁基氢化铝 、 potassium carbonate 作用下， 以 四氢呋喃 、 甲醇 、 N,N-二甲基甲酰胺 、 苯 为溶剂， 反应 3.0h， 生成 (4E,6E)-1,9-Bis-(tert-butyl-dimethyl-silanyloxy)-10-(4-methoxy-benzyloxy)-6-methyl-deca-4,6-dien-3-ol
  参考文献：
  名称：

  A study toward a total synthesis of fostriecin

  摘要：

  In order to synthesize the major C(3)-C(12) part of fostriecin, asymmetric dihydroxylation of several dienes 5a-f, prepared by cross-coupling reactions of several types. vas studied, thus providing high dependency on the hydroxyl groups at C(5) and C(l 1). The best regioselectivity was obtained with 5d to produce diol 23. which was later transformed into the advanced intermediate 26. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)00403-3