2-heptylamino-5,8-dimethoxy-1,4-naphthoquinone | 1190835-82-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮
• 英文名称: 2-heptylamino-5,8-dimethoxy-1,4-naphthoquinone
• 英文别名: 2-(Heptylamino)-5,8-dimethoxynaphthalene-1,4-dione
• CAS: 1190835-82-5
• 化学式: C₁₉H₂₅NO₄
• 分子量: 331.412
• InChiKey: QMQPWZHNYFUOOD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  24
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  64.6
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• CHEMICAL INHIBITOR OF P53-SNAIL BINDING AND PHARMACEUTICAL COMPOSITION FOR TREATING CANCER DISEASE CONTAINING SAME AS ITS ACTIVE INGREDIENT
  申请人：Park Bum Joon

  公开号：US20120015960A1

  公开（公告）日：2012-01-19

  Provided are compounds for inhibiting Snail-p53 binding and therapeutic agents for cancer including the compounds as an effective component. The Snail-p53 binding inhibitors induce expression of p53 in K-Ras mutant cell lines, thereby enabling effective treatment or prevention of K-Ras mutant cancer, such as, pancreatic cancer, lung cancer, cholangioma, and colon cancer, of which diagnosis or treatment is not easy.

  提供了用于抑制蜗牛蛋白（Snail）与p53结合的化合物，以及作为有效成分的治疗癌症的药物。蜗牛蛋白（Snail）-p53结合抑制剂诱导K-Ras突变细胞系中p53的表达，从而实现对K-Ras突变癌症（如胰腺癌、肺癌、胆管癌和结肠癌）的有效治疗或预防，其中的诊断或治疗并不容易。
• COMPOUND FOR INHIBITING SNAIL-P53 BINDING AND THERAPEUTIC AGENT FOR CANCER INCLUDING THE COMPOUND AS EFFECTIVE COMPONENT
  申请人：THE INDUSTRY & ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIVERSITY

  公开号：US20140147866A1

  公开（公告）日：2014-05-29

  Provided are compounds for inhibiting Snail-p53 binding and therapeutic agents for cancer including the compounds as an effective component. The Snail-p53 binding inhibitors induce expression of p53 in K-Ras mutant cell lines, thereby enabling effective treatment or prevention of K-Ras mutant cancer, such as, pancreatic cancer, lung cancer, cholangioma, and colon cancer, of which diagnosis or treatment is not easy.

  提供了抑制蜗牛-p53结合的化合物以及包括该化合物作为有效成分的治疗癌症的药物。这些蜗牛-p53结合抑制剂能够在K-Ras突变细胞系中诱导p53的表达，从而使K-Ras突变癌症如胰腺癌、肺癌、胆管癌和结肠癌的治疗或预防变得更加有效，这些癌症的诊断或治疗并不容易。
• METHOD OF SCREENING A THERAPEUTIC AGENT FOR K-RAS MUTANT CANCER
  申请人：RAND Bio Science Inc.

  公开号：EP3182129B1

  公开（公告）日：2018-12-26
• US9400281B2
  申请人：——

  公开号：US9400281B2

  公开（公告）日：2016-07-26