5-Hydroxy-7-methyl-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one | 62845-20-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异黄酮类化合物
• 英文名称: 5-Hydroxy-7-methyl-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
• 英文别名: 4',5-Dihydroxy 7-methyl isoflavone；5-hydroxy-3-(4-hydroxyphenyl)-7-methylchromen-4-one
• CAS: 62845-20-9
• 化学式: C₁₆H₁₂O₄
• 分子量: 268.269
• InChiKey: ZRIJCEPDBSCRBN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• INHIBITION AND TREATMENT OF PROSTATE CANCER METASTASIS
  申请人：Bergan Raymond C.

  公开号：US20120283313A1

  公开（公告）日：2012-11-08

  The present invention provides compounds and methods of inhibiting and treating metastatic prostate cancer. The compounds include MEK4 inhibitors. In another aspect the invention provides methods of identifying inhibitors of metastatic prostate cancer by screening for inhibitors of MEK4.

  本发明提供了抑制和治疗转移性前列腺癌的化合物和方法。这些化合物包括MEK4抑制剂。另一方面，本发明提供了通过筛选MEK4抑制剂来识别转移性前列腺癌抑制剂的方法。
• Ground mixture
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0129893A2

  公开（公告）日：1985-01-02

  A ground mixture of a poorly soluble cystalline drug and an adsorbent is remarkably improved in the rates of dissolution and absorption of the drug.

  将溶解性较差的胱氨酸药物和吸附剂混合研磨后，可显著提高药物的溶解和吸收率。
• PRODUCTION OF PROANTHOCYANIDINS TO IMPROVE FORAGE QUALITY
  申请人：Dixon Richard A.

  公开号：US20090083874A1

  公开（公告）日：2009-03-26

  The invention provides method and compositions for the modulation of anthocyanin and proanthocyanidin production in plants. The methods of the invention allow creation of plants having novel phenotypes. Increased expression of anthocyanins and proanthocyanidins in plants may be used to increase the nutritional value of food plants for both human and animal consumption. Increased proanthocyanidin content also reduces the potential for bloat in animals fed certain forage plants low in condensed tannin content. The invention may also be used to modify plant pigmentation, and for nutraceutical and food colorant production.
• US4772627A
  申请人：——

  公开号：US4772627A

  公开（公告）日：1988-09-20
• US7880059B2
  申请人：——

  公开号：US7880059B2

  公开（公告）日：2011-02-01