6-methyl-2-hydroxy-3-ethyl-1,4-naphthoquinone | 1174548-09-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮
• 英文名称: 6-methyl-2-hydroxy-3-ethyl-1,4-naphthoquinone
• CAS: 1174548-09-4
• 化学式: C₁₃H₁₂O₃
• 分子量: 216.236
• InChiKey: MIDWFOGTQANKRX-UHFFFAOYSA-N

物化性质

• 熔点：
  140-142 °C
• 沸点：
  392.8±42.0 °C(predicted)
• 密度：
  1.276±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  16.0
• 可旋转键数：
  1.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  54.37
• 氢给体数：
  1.0
• 氢受体数：
  3.0

文献信息

• Naphthalene anti-psoriatic agents
  申请人：SYNTEX (U.S.A.) INC.

  公开号：EP0150831A2

  公开（公告）日：1985-08-07

  Psoriasis in mammals is relieved by topically administering naphthalenes of the formula: wherein: R' is alkoxy of one to twelve carbon atoms, of one to twelve carbon atoms, alkylthio of one to twelve carbon atoms, optionally substituted phenoxy or optionally substituted phenylthio; R2 is hydrogen, lower alkyl, optionally substituted phenyl or optionally substituted phenylalkyl; R3 is lower alkyl, lower alkoxy, or halo and m is 0, 1 or 2, or R3 is optionally substituted phenyl, optionally substituted phenyl lower alkyl, optionally substituted phenyl lower alkoxy, amino, lower alkylamino, lower dialkylamino, cyano, or S(O)nR wherein R is lower alkyl; optionally substituted phenyl; optionally substituted phenyl lower alkyl; or optionally substituted heterocyclic aryl of three to nine ring atoms containing one or two heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur, and the pharmaceutically acceptable acid addition salts thereof; and m is 1 and n is 0, 1 or 2; and W is alkyl of one to seven carbon atoms, optionally substituted phenyl or optionally substituted benzyl.

  哺乳动物的牛皮癣可通过局部施用式中的萘来缓解： 其中 R'是一至十二个碳原子的烷氧基、一至十二个碳原子的烷氧基、一至十二个碳原子的烷硫基、任选取代的苯氧基或任选取代的苯硫基； R2 是氢、低级烷基、任选取代的苯基或任选取代的苯基烷基； R3 是低级烷基、低级烷氧基或卤素，m 是 0、1 或 2，或者 R3 是任选取代的苯基、任选取代的苯基低级烷基、任选取代的苯基低级烷氧基、氨基、低级烷基氨基、低级二烷基氨基、氰基或 S(O)nR 其中 R 是低级烷基；任选取代的苯基；任选取代的苯基低级烷基；或任选取代的三至九个环原子的杂环芳基，含有一个或两个选自氮、氧和硫的杂原子，以及它们的药学上可接受的酸加成盐；且 m 为 1，n 为 0、1 或 2；以及 W 是一至七个碳原子的烷基、任选取代的苯基或任选取代的苄基。
• Polymer scale preventive agent, polymerization vessel effective in preventing polymer scale deposition, and process of producing polymer using said vessel
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：EP0534436A1

  公开（公告）日：1993-03-31

  A polymer scale preventive agent for use in polymerization of a monomer having an ethylenically unsaturated double bond, comprising: (A) at least one compound selected from the group consisting of diaminobenzenes and diaminonaphthalenes, (B) a hydroxynaphthoquinone, and (C) an acid. The polymerization vessel having a coating comprising the polymer scale preventive agent on its inner wall, etc. is effective in preventing deposition of polymer scale, and the polymeric product has a high whiteness and is of high quality.

  一种聚合物防垢剂，用于具有乙烯不饱和双键的单体的聚合，包括 (A) 至少一种选自由二氨基苯和二氨基萘组成的组的化合物、 (B) 一种羟基萘醌，和 (C) 酸。在聚合容器内壁等处涂覆聚合物防垢剂可有效防止聚合物垢沉积，聚合产品白度高、质量好。
• US5091558A
  申请人：——

  公开号：US5091558A

  公开（公告）日：1992-02-25
• US5411675A
  申请人：——

  公开号：US5411675A

  公开（公告）日：1995-05-02