3-(4-hydroxyphenyl)-4-(4-hydroxyphenyl)-8-methylchroman-7-ol | 1374524-55-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异黄酮类化合物
• 英文名称: 3-(4-hydroxyphenyl)-4-(4-hydroxyphenyl)-8-methylchroman-7-ol
• 英文别名: ME-344；3,4-bis(4-hydroxyphenyl)-8-methyl-3,4-dihydro-2H-chromen-7-ol
• CAS: 1374524-55-6
• 化学式: C₂₂H₂₀O₄
• 分子量: 348.398
• InChiKey: QVCAATSEPLQVBX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  26
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  69.9
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• [EN] ISOFLAVONOID COMPOUNDS AND METHODS FOR THE TREATMENT OF CANCER<br/>[FR] COMPOSÉS D'ISOFLAVONOÏDES ET PROCÉDÉS POUR LE TRAITEMENT DU CANCER
  申请人：MARSHALL EDWARDS INC

  公开号：WO2012061409A1

  公开（公告）日：2012-05-10

  Provided herein is a pharmaceutical composition comprising at least one isoflavonoid. Also provided herein are methods of treating cancer, sensitizing cancer cells, and inducing apoptosis in cancer cells by administering such compositions.

  本发明提供了一种含有至少一种异黄酮类化合物的制药组合物。本发明还提供了通过给予该组合物来治疗癌症、增加癌细胞敏感性和诱导癌细胞凋亡的方法。
• [EN] COMBINATION THERAPIES<br/>[FR] POLYTHÉRAPIES
  申请人：MEI PHARMA INC

  公开号：WO2021252776A1

  公开（公告）日：2021-12-16

  Provided herein are compositions, methods, and kits for treating cancer comprising a mitochondrial inhibitor and a Bcl-2 inhibitor.

  本文提供了一种治疗癌症的组合物、方法和试剂盒，包括线粒体抑制剂和Bcl-2抑制剂。
• REMISSION THERAPY OF CANCER WITH ISOFLAVONOIDS
  申请人：Alvero Ayesha B.

  公开号：US20120251630A1

  公开（公告）日：2012-10-04

  Provided herein is a method of reducing incidences of cancer recurrence. The method involves administering to an individual in cancer remission an isoflavonoid. In specific instances, the treated individual is in remission from epithelial cancer, such as ovarian cancer or breast cancer.

  本文提供了一种减少癌症复发率的方法。该方法涉及向癌症缓解期的个体施用异黄酮。在某些情况下，接受治疗的个体正在缓解期，如卵巢癌或乳腺癌。
• METHOD OF TREATING VIRAL INFECTIONS
  申请人：EPIPHANY BIOSCIENCES

  公开号：US20150050241A1

  公开（公告）日：2015-02-19

  The present invention is directed to methods and compositions employing 9-(4-hydroxy-2-(hydroxymethyl)butyl)guanine (“H2G”) or derivatives or analogs thereof for the treatment of viral diseases, as well as for the treatment of other conditions, including, but not limited to, cancer, chronic fatigue syndrome, Alzheimer's disease, multiple sclerosis and Graves' disease. The H2G or derivative or analog thereof can be administered in a pharmaceutical composition and can be administered with an additional antiviral therapeutic agent or another agent for the treatment of other conditions.

  本发明涉及使用9-（4-羟基-2-（羟甲基）丁基）鸟嘌呤（“H2G”）或其衍生物或类似物的方法和组合物，用于治疗病毒性疾病，以及用于治疗其他疾病，包括但不限于癌症、慢性疲劳综合征、阿尔茨海默病、多发性硬化症和格雷夫斯病。 H2G或其衍生物或类似物可以在药物组合物中给予，并且可以与其他抗病毒治疗药物或其他治疗其他疾病的药物一起给予。
• Isoflavonoid compounds and methods for the treatment of cancer
  申请人：MEI Pharma, Inc.

  公开号：US10105346B2

  公开（公告）日：2018-10-23

  Provided herein is a pharmaceutical composition comprising at least one isoflavonoid. Also provided herein are methods of treating cancer, sensitizing cancer cells, and inducing apoptosis in cancer cells by administering such compositions.

  本文提供了一种包含至少一种异黄酮的药物组合物。本文还提供了通过施用此类组合物治疗癌症、敏化癌细胞和诱导癌细胞凋亡的方法。