3-(4-hydroxyphenyl)-4-(4-hydroxy-3-methylphenyl)-8-methylchroman-7-ol | 1374524-57-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异黄酮类化合物
• 英文名称: 3-(4-hydroxyphenyl)-4-(4-hydroxy-3-methylphenyl)-8-methylchroman-7-ol
• 英文别名: 4-(4-hydroxy-3-methylphenyl)-3-(4-hydroxyphenyl)-8-methyl-3,4-dihydro-2H-chromen-7-ol
• CAS: 1374524-57-8
• 化学式: C₂₃H₂₂O₄
• 分子量: 362.425
• InChiKey: BUPLJKFMEIUAEV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  27
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  69.9
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• [EN] ISOFLAVONOID COMPOUNDS AND METHODS FOR THE TREATMENT OF CANCER<br/>[FR] COMPOSÉS D'ISOFLAVONOÏDES ET PROCÉDÉS POUR LE TRAITEMENT DU CANCER
  申请人：MARSHALL EDWARDS INC

  公开号：WO2012061409A1

  公开（公告）日：2012-05-10

  Provided herein is a pharmaceutical composition comprising at least one isoflavonoid. Also provided herein are methods of treating cancer, sensitizing cancer cells, and inducing apoptosis in cancer cells by administering such compositions.

  本发明提供了一种含有至少一种异黄酮类化合物的制药组合物。本发明还提供了通过给予该组合物来治疗癌症、增加癌细胞敏感性和诱导癌细胞凋亡的方法。
• [EN] COMBINATION THERAPIES<br/>[FR] POLYTHÉRAPIES
  申请人：MEI PHARMA INC

  公开号：WO2021252776A1

  公开（公告）日：2021-12-16

  Provided herein are compositions, methods, and kits for treating cancer comprising a mitochondrial inhibitor and a Bcl-2 inhibitor.

  本文提供了一种治疗癌症的组合物、方法和试剂盒，包括线粒体抑制剂和Bcl-2抑制剂。
• REMISSION THERAPY OF CANCER WITH ISOFLAVONOIDS
  申请人：Alvero Ayesha B.

  公开号：US20120251630A1

  公开（公告）日：2012-10-04

  Provided herein is a method of reducing incidences of cancer recurrence. The method involves administering to an individual in cancer remission an isoflavonoid. In specific instances, the treated individual is in remission from epithelial cancer, such as ovarian cancer or breast cancer.

  本文提供了一种减少癌症复发率的方法。该方法涉及向癌症缓解期的个体施用异黄酮。在某些情况下，接受治疗的个体正在缓解期，如卵巢癌或乳腺癌。
• Isoflavonoid compounds and methods for the treatment of cancer
  申请人：MEI Pharma, Inc.

  公开号：US10105346B2

  公开（公告）日：2018-10-23

  Provided herein is a pharmaceutical composition comprising at least one isoflavonoid. Also provided herein are methods of treating cancer, sensitizing cancer cells, and inducing apoptosis in cancer cells by administering such compositions.

  本文提供了一种包含至少一种异黄酮的药物组合物。本文还提供了通过施用此类组合物治疗癌症、敏化癌细胞和诱导癌细胞凋亡的方法。
• Isoflavonoid compositions and methods for the treatment of cancer
  申请人：MEI PHARMA, INC.

  公开号：US10369132B2

  公开（公告）日：2019-08-06

  Provided herein is a pharmaceutical composition comprising an isoflavonoid derivative and a cyclodextrin. Also provided herein are methods of treating cancer, sensitizing cancer cells, and inducing apoptosis in cancer cells by administering such compositions. In specific instances, provided herein are intravenous compositions and therapies.

  本文提供了一种药物组合物，该组合物由异黄酮衍生物和环糊精组成。本文还提供了通过施用此类组合物治疗癌症、敏化癌细胞和诱导癌细胞凋亡的方法。具体而言，本文提供了静脉注射组合物和疗法。