1,7-bis(4-dimethylaminophenyl)-4-N-phenylaminocarbonylhepta-1E,6E-dien-3,5-dione | 1255639-44-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮
• 英文名称: 1,7-bis(4-dimethylaminophenyl)-4-N-phenylaminocarbonylhepta-1E,6E-dien-3,5-dione
• 英文别名: (E)-5-[4-(dimethylamino)phenyl]-2-[(E)-3-[4-(dimethylamino)phenyl]prop-2-enoyl]-3-oxo-N-phenylpent-4-enamide
• CAS: 1255639-44-1
• 化学式: C₃₀H₃₁N₃O₃
• 分子量: 481.594
• InChiKey: RDXZRIXKZPVQIY-OZNQKUEASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  36
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  69.7
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Curcumin analogues as zinc chelators and their uses
  申请人：Johnson Francis

  公开号：US10669227B2

  公开（公告）日：2020-06-02

  This invention provides a compound having the structure wherein α, β, X, Y, and R1-R11 are defined herein. This invention also provides a pharmaceutical composition comprising the above compounds, a method of inhibiting the activity and/or levels of a matrix metalloproteinase (MMP), a method of inhibiting the production of a cytokine in a population of cells, a method of inhibiting the production of a growth factor in a population of cells, and a method of inhibiting NFκ-B activation in a population of cells.

  本发明提供了一种具有以下结构的化合物 其中 α、β、X、Y 和 R1-R11 在本文中定义。本发明还提供了一种包含上述化合物的药物组合物、一种抑制基质金属蛋白酶（MMP）活性和/或水平的方法、一种抑制细胞群中细胞因子产生的方法、一种抑制细胞群中生长因子产生的方法以及一种抑制细胞群中 NFκ-B 激活的方法。
• CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES
  申请人：The Research Foundation for The State University of New York

  公开号：EP3206488B1

  公开（公告）日：2019-08-21
• CHEMICALLY MODIFIED CURCUMINS AS INHIBITORS OF ANTHRAX LETHAL FACTOR
  申请人：ANTONELLI Anthony

  公开号：US20150073021A1

  公开（公告）日：2015-03-12

  The present invention provides a method of inhibiting the binding of anthrax lethal factor with protective antigen comprising contacting the anthrax lethal factor with a compound having the structure:
• POLYENOLIC ZINC-BINDING AGENTS (PEZBINS) ACTIVELY PROMOTE INACTIVATION OF CANCER STEM CELLS AND POTENTIATE CYTOTOXIC ANTI-TUMOR DRUG SUBSTANCES
  申请人：Golub Lorne M.

  公开号：US20150150834A1

  公开（公告）日：2015-06-04

  The present invention provides a method of inhibiting the growth of or promoting differentiation and destruction of cancer stem cells (CSCs) comprising contacting the cancer stem cells with a compound having the structure: or a pharmaceutically acceptable salt thereof.
• US9187406B2
  申请人：——

  公开号：US9187406B2

  公开（公告）日：2015-11-17