(4E)-5,9-dimethyldeca-4,8-dien-3-amine | 1192302-66-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (4E)-5,9-dimethyldeca-4,8-dien-3-amine
• CAS: 1192302-66-1
• 化学式: C₁₂H₂₃N
• 分子量: 181.321
• InChiKey: WGYKAVWWNQSKEH-PKNBQFBNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (4E)-5,9-dimethyldeca-4,8-dien-3-amine 、 氯乙酰氯 在 吡啶 作用下， 以 四氢呋喃 为溶剂， 反应 0.5h， 生成 (E)-2-chloro-N-(5,9-dimethyldeca-4,8-dien-3-yl)acetamide
  参考文献：
  名称：

  Synthesis of novel [1,2]-diamines with antituberculosis activity

  摘要：

  Guided by the metabolism information of SQ109, derivatives with substituted geranylamine moiety or substituted admantane ring of SQ109 were synthesized and evaluated as antituberculosis agents. Among all tested compounds, compound 11c showed the most potent antituberculosis activity with MIC value of 0.3 mu M against Mycobacterium tuberculosis H37Rv. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.07.126
• 作为产物：
  描述：

  (E)-2-(5,9-dimethyldeca-4,8-dien-3-yl)isoindoline-1,3-dione 在 甲胺 作用下， 以 甲醇 为溶剂， 反应 12.0h， 生成 (4E)-5,9-dimethyldeca-4,8-dien-3-amine
  参考文献：
  名称：

  Synthesis of novel [1,2]-diamines with antituberculosis activity

  摘要：

  Guided by the metabolism information of SQ109, derivatives with substituted geranylamine moiety or substituted admantane ring of SQ109 were synthesized and evaluated as antituberculosis agents. Among all tested compounds, compound 11c showed the most potent antituberculosis activity with MIC value of 0.3 mu M against Mycobacterium tuberculosis H37Rv. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.07.126

文献信息

• TERPENOID ANALOGUES AND USES THEREOF FOR TREATING NEUROLOGICAL CONDITIONS
  申请人：Reed Mark A.

  公开号：US20130267571A1

  公开（公告）日：2013-10-10

  The present application provides a terpene analogue of Formula (I) or a pharmaceutically acceptable isomer, salt or ester thereof, and methods and uses thereof for treating neurological conditions such as pain in general and neuropathic pain. These terpene analogues can also be used to treat other electrical disorders in the central and peripheral nervous system. Also provided are methods of synthesizing the terpene analogues of Formula I.

  本申请提供了公式(I)的萜烯类似物或其药学上可接受的异构体、盐或酯，以及用于治疗神经疾病，如一般疼痛和神经病性疼痛的方法和用途。这些萜烯类似物还可以用于治疗中枢神经系统和外周神经系统中的其他电障碍。同时提供了合成公式I的萜烯类似物的方法。
• [EN] TERPENOID ANALOGUES AND USES THEREOF FOR TREATING NEUROLOGICAL CONDITIONS<br/>[FR] ANALOGUES DES TERPÉNOÏDES ET LEURS UTILISATIONS POUR LE TRAITEMENT DE TROUBLES NEUROLOGIQUES
  申请人：NEUROQUEST INC

  公开号：WO2012034232A1

  公开（公告）日：2012-03-22

  The present application provides a terpene analogue of Formula (I) or a pharmaceutically acceptable isomer, salt or ester thereof, and methods and uses thereof for treating neurological conditions such as pain in general and neuropathic pain. These terpene analogues can also be used to treat other electrical disorders in the central and peripheral nervous system. Also provided are methods of synthesizing the terpene analogues of Formula I.
• Synthesis of novel [1,2]-diamines with antituberculosis activity
  作者：Qingyi Meng、Huibing Luo、Yilang Chen、Tiancai Wang、Qizheng Yao

  DOI：10.1016/j.bmcl.2009.07.126

  日期：2009.9

  Guided by the metabolism information of SQ109, derivatives with substituted geranylamine moiety or substituted admantane ring of SQ109 were synthesized and evaluated as antituberculosis agents. Among all tested compounds, compound 11c showed the most potent antituberculosis activity with MIC value of 0.3 mu M against Mycobacterium tuberculosis H37Rv. (C) 2009 Elsevier Ltd. All rights reserved.