(E)-9-(4-tert-butylphenyl)-N-(2,4-difluorophenyl)-6,7-dihydro-5H-imidazo[1,5-a]azepine-8-carboxamide | 1126427-71-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮
• 英文名称: (E)-9-(4-tert-butylphenyl)-N-(2,4-difluorophenyl)-6,7-dihydro-5H-imidazo[1,5-a]azepine-8-carboxamide
• 英文别名: 9-(4-tert-butylphenyl)-N-(2,4-difluorophenyl)-6,7-dihydro-5H-imidazo[1,5-a]azepine-8-carboxamide
• CAS: 1126427-71-1
• 化学式: C₂₅H₂₅F₂N₃O
• 分子量: 421.49
• InChiKey: INZUGRZHSSSLGG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  46.9
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• HETEROCYCLODIAZEPINE CANNABINOID RECEPTOR MODULATORS FOR TREATMENT OF DISEASE
  申请人：Gahman Timothy C.

  公开号：US20090062253A1

  公开（公告）日：2009-03-05

  The present invention relates to compounds and methods useful as modulators of CB2 for the treatment or prevention of disease states including, but not limited to pain, autoimmune disease, malabsorption syndrome, pulmonary disease, osteoporosis, muscle spasm in cancer, neuromuscular disorder, and atherosclerosis progression.

  本发明涉及化合物和方法，用作CB2的调节剂，用于治疗或预防疾病状态，包括但不限于疼痛、自身免疫疾病、吸收不良综合征、肺部疾病、骨质疏松症、癌症中的肌肉痉挛、神经肌肉障碍和动脉粥样硬化进展。
• [EN] HETEROCYCLODIAZEPINE CANNABINOID RECEPTOR MODULATORS FOR TREATMENT OF DISEASE<br/>[FR] MODULATEURS DES RÉCEPTEURS CANNABINOÏDES À BASE D' HÉTÉROCYCLODIAZÉPINE POUR TRAITER UNE MALADIE
  申请人：KALYPSYS INC

  公开号：WO2009032754A2

  公开（公告）日：2009-03-12

  The present invention relates to compounds and methods useful as modulators of CB2 for the treatment or prevention of disease states including, but not limited to pain, autoimmune disease, malabsorption syndrome, pulmonary disease, osteoporosis, muscle spasm in cancer, neuromuscular disorder, and atherosclerosis progression.