(1S,5R,7R)-10,10-Dimethyl-4-nitroso-3-thia-4-aza-tricyclo[5.2.1.01,5]decane 3,3-dioxide | 139331-00-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (1S,5R,7R)-10,10-Dimethyl-4-nitroso-3-thia-4-aza-tricyclo[5.2.1.01,5]decane 3,3-dioxide
• CAS: 139331-00-3
• 化学式: C₁₀H₁₆N₂O₃S
• 分子量: 244.315
• InChiKey: OQIFCXOFBCTIPF-NQMVMOMDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.51
• 重原子数：
  16.0
• 可旋转键数：
  1.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  66.81
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  (2R)-bornane-10,2-sultam 在 亚硝酸特丁酯 作用下， 以 四氢呋喃 为溶剂， 以99%的产率得到(1S,5R,7R)-10,10-Dimethyl-4-nitroso-3-thia-4-aza-tricyclo[5.2.1.01,5]decane 3,3-dioxide
  参考文献：
  名称：

  Asymmetric Diels-Alder reactions of a nitroso compound derived from D-bornane-10,2-sultam

  摘要：

  Acylnitroso dienophile 3 derived from D-bornane-10,2-sultam undergoes cycloaddition with high yields and complete facial selectivity to cyclopentadiene and cyclohexadiene. When the nitroso group is attached to the sultam nitrogen, it is no longer reactive in Diels-Alder reactions.

  DOI：

  10.1016/s0957-4166(00)80015-4

文献信息

• New acylnitroso compounds for the asymmetric oxyamination of dienes
  作者：V. Gouverneur、S.J. McCarthy、C. Mineur、D. Belotti、G. Dive、L. Ghosez

  DOI：10.1016/s0040-4020(98)00504-3

  日期：1998.8

  A series of new enantiomerically pure acylnitroso compounds have been prepared and tested as dienophiles for the asymmetric oxyamination of dienes. Very high selectivities were obtained with acylnitroso compounds derived from diphenylmethoxymethyl pyrrolidine 2c, the C-2-symmetric pyrrolidines 2d-e and camphorsultam 2f. (C) 1998 Elsevier Science Ltd. All rights reserved.