(S)-N-(1-(2-hydroxyethylamino)-3,3-dimethyl-1-oxobutan-2-yl)-6-methyl-3-(2,4,5-trifluorophenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-1-carboxamide | 1231909-47-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮
• 英文名称: (S)-N-(1-(2-hydroxyethylamino)-3,3-dimethyl-1-oxobutan-2-yl)-6-methyl-3-(2,4,5-trifluorophenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-1-carboxamide
• 英文别名: N-[(2S)-1-(2-hydroxyethylamino)-3,3-dimethyl-1-oxobutan-2-yl]-6-methyl-3-(2,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridine-1-carboxamide
• CAS: 1231909-47-9
• 化学式: C₂₂H₂₈F₃N₅O₃
• 分子量: 467.491
• InChiKey: RWLWNXWKXJXQGG-LJQANCHMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  99.5
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• BICYCLIC PYRAZOLO-HETEROCYCLES
  申请人：Luo Robert Zhiyong

  公开号：US20110144121A1

  公开（公告）日：2011-06-16

  The present invention provides substituted pyrazolo-heterocycles having the general structure of formula I Also provided are pharmaceutically acceptable salts, acid salts, hydrates, solvates and stereoisomers of the compounds of formula I. The compounds are useful as modulators of cannabinoid receptors and for the prophylaxis and treatment of cannabinoid receptor-associated diseases and conditions, such as pain, inflammation and pruritis.

  本发明提供了具有一般式I的取代吡唑杂环化合物，还提供了公认的药用盐、酸盐、水合物、溶剂合物和化合物I的立体异构体。这些化合物可用于调节大麻素受体，并用于预防和治疗与大麻素受体相关的疾病和病况，例如疼痛、炎症和瘙痒。
• US7741350B1
  申请人：——

  公开号：US7741350B1

  公开（公告）日：2010-06-22
• US8211926B2
  申请人：——

  公开号：US8211926B2

  公开（公告）日：2012-07-03
• US8653127B2
  申请人：——

  公开号：US8653127B2

  公开（公告）日：2014-02-18
• [EN] BICYCLIC PYRAZOLO-HETEROCYCLES<br/>[FR] HÉTÉROCYCLES PYRAZOLO BICYCLIQUES
  申请人：CARA THERAPEUTICS INC

  公开号：WO2010088050A2

  公开（公告）日：2010-08-05

  The present invention provides substituted pyrazolo-heterocycles having the general structure of formula I (I). The structures of rings A and B and substituents Ra, Rb and Rc are described in the specification. Also provided are pharmaceutically acceptable salts, acid salts, hydrates, solvates and stereoisomers of the compounds of formula I. The compounds are useful as modulators of cannabinoid receptors and for the prophylaxis, treatment and inhibition of cannabinoid receptor- associated diseases and conditions, such as pain, inflammation and pruritis.