methoxygaertneroside | 497178-43-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: methoxygaertneroside
• 英文别名: methyl (1S,4aS,7R,7aS)-4'-[(S)-hydroxy-(4-hydroxy-3-methoxyphenyl)methyl]-5'-oxo-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyspiro[4a,7a-dihydro-1H-cyclopenta[c]pyran-7,2'-furan]-4-carboxylate
• CAS: 497178-43-5
• 化学式: C₂₇H₃₀O₁₄
• 分子量: 578.527
• InChiKey: SERITHPGXJNZPQ-PYBGUIRTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  41
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  211
• 氢给体数：
  6
• 氢受体数：
  14

反应信息

• 作为反应物：
  描述：

  methoxygaertneroside 在 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 1,4-二氧六环 为溶剂， 以98%的产率得到dehydromethoxygaertneroside
  参考文献：
  名称：

  New anti-malarial phenylpropanoid conjugated iridoids from Morinda morindoides

  摘要：

  A new phenylpropanoid conjugated iridoid together with four known congeners was isolated from Morinda morindoides, used for the therapy of malaria traditionally in some African countries, as anti-malarial principles through bioassay-guided separation. Furthermore, their absolute stereostructures were unambiguously established by a combination of modified Mosher's method and chemical correlation. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.01.095
• 作为产物：
  描述：

  methyl (1S,4aS,7R,7aS)-1-[(2S,3R,4S,5S,6R)-6-(acetyloxymethyl)-3,4,5-trihydroxyoxan-2-yl]oxy-4'-[(S)-hydroxy-(4-hydroxy-3-methoxyphenyl)methyl]-5'-oxospiro[4a,7a-dihydro-1H-cyclopenta[c]pyran-7,2'-furan]-4-carboxylate 在 sodium methylate 作用下， 以 甲醇 为溶剂， 以89%的产率得到methoxygaertneroside
  参考文献：
  名称：

  New anti-malarial phenylpropanoid conjugated iridoids from Morinda morindoides

  摘要：

  A new phenylpropanoid conjugated iridoid together with four known congeners was isolated from Morinda morindoides, used for the therapy of malaria traditionally in some African countries, as anti-malarial principles through bioassay-guided separation. Furthermore, their absolute stereostructures were unambiguously established by a combination of modified Mosher's method and chemical correlation. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.01.095

文献信息

• New anti-malarial phenylpropanoid conjugated iridoids from Morinda morindoides
  作者：Satoru Tamura、Bruno Kilunga Kubata、Syamsurizal、Sawako Itagaki、Toshihiro Horii、Muzele Kalulu Taba、Nobutoshi Murakami

  DOI：10.1016/j.bmcl.2010.01.095

  日期：2010.3

  A new phenylpropanoid conjugated iridoid together with four known congeners was isolated from Morinda morindoides, used for the therapy of malaria traditionally in some African countries, as anti-malarial principles through bioassay-guided separation. Furthermore, their absolute stereostructures were unambiguously established by a combination of modified Mosher's method and chemical correlation. (C) 2010 Elsevier Ltd. All rights reserved.