(E)-3-( 4-( (tert-butyldimethylsilyl)oxy)-3-methoxyphenyl)prop-2-en-1-ol | 290820-48-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂醇
• 英文名称: (E)-3-( 4-( (tert-butyldimethylsilyl)oxy)-3-methoxyphenyl)prop-2-en-1-ol
• 英文别名: (E)-3-(4-((tert-butyldimethylsilyl)oxy)-3-methoxyphenyl)prop-2-en-1-ol；(E)-3-[4-[tert-butyl(dimethyl)silyl]oxy-3-methoxyphenyl]prop-2-en-1-ol
• CAS: 290820-48-3
• 化学式: C₁₆H₂₆O₃Si
• 分子量: 294.466
• InChiKey: SGRWGJLRWDYROG-BQYQJAHWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.08
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (E)-3-( 4-( (tert-butyldimethylsilyl)oxy)-3-methoxyphenyl)prop-2-en-1-ol 在 palladium on activated charcoal 氢气 、 sodium hydride 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 生成 Phenethyl-thiocarbamic acid O-{3-[4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-phenyl]-propyl} ester
  参考文献：
  名称：

  Chain-Branched acyclic phenethylthiocarbamates as vanilloid receptor antagonists

  摘要：

  A series of acyclic phenethylthiocarbamate derivatives have been synthesized, and their antagonist effect against vanilloid receptor tested. Chain branching led to a significant change in antagonist activity of the parent molecule. Ethyl-branched le showed a 6.3 muM Of IC50 value in Ca-45(2+)-influx assay. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00178-1
• 作为产物：
  描述：

  香草醛 在 咪唑 、 sodium hexamethyldisilazane 、 二异丁基氢化铝 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 59.0h， 生成 (E)-3-( 4-( (tert-butyldimethylsilyl)oxy)-3-methoxyphenyl)prop-2-en-1-ol
  参考文献：
  名称：

  [EN] NEUROPROTECTIVE AGENTS FOR TREATMENT OF NEURODEGENERATIVE DISEASES
  [FR] AGENTS NEUROPROTECTEURS POUR LE TRAITEMENT DE MALADIES NEURODÉGÉNÉRATIVES

  摘要：

  化合物I的化学式对治疗神经退行性疾病有用：I，其中R1是一个C1-12有机基团；是一个含有5到12个环原子和最多三个异原子（分别选自N、O、S和Se）的C1-12杂环环系统；R2是C1-12有机基团；R7、R8分别独立地是氢（H）、羟基、羰基（即酮基）、C1-8烷基、C1-8烷氧基、C2-8烯基、C2-10炔基、C5-7环烷基、C5-7环烯基、卤素、C1-4醛基，或-NR4q，其中R4是H、C1-8烷基、C2-8烯基、C4-8环烷基、C4-8环烯基或C6-10芳基；o为0、1、2、3或4；A是一个C6-12芳基、C5-12杂芳基，或一个可选择地取代的3-羟基吡啶-4(1H)-酮；p是一个从1到6的整数；Zm不存在或是一个二价连接基团；m是表示Z重复次数的整数。

  公开号：

  WO2014085600A1

文献信息

• NEUROPROTECTIVE AGENTS FOR TREATMENT OF NEURODEGENERATIVE DISEASES
  申请人：WAYNE STATE UNIVERSITY

  公开号：US20150299180A1

  公开（公告）日：2015-10-22

  A compound having formula I is useful for treating a neurodegenerative disease: R 1 is an C 1-12 organyl group; is a C 1-12 heterocyclic ring system containing 5 to 12 ring atoms and up to three heteroatoms individually selected from the group consisting of N, O, S, and Se; R 2 are C 1-12 organyl groups; R 7 , R 8 are each independently, hydrogen (H), hydroxyl, oxo (i.e., carbonyl), C 1-8 alkyl, C 1-8 alkoxyl, C 2-8 alkenyl, C 2-10 alkynyl, C 5-7 cycloalkyl, C 5-7 cycloalkenyl, halo, C 1-4 aldehyde, or —NR 4 q where R 4 is H, C 1-8 alkyl, C 2-8 alkenyl, C 4-8 cycloalkyl, C 4-8 cycloalkenyl, or C 6-10 aryl; o is 0, 1, 2, 3, or 4; A is a C 6-12 aryl group, C 5-12 heteroaryl group, or an optionally substituted 3-hydroxypyridin-4(1H)-one; p is an integer from 1 to 6; and Z m is absent or a divalent linking moiety; and m is an integer representing the number of time Z is repeated.

  化合物I的化学式对治疗神经退行性疾病有用：R1是C1-12有机基团；是含有5到12个环原子和最多三个异原子（选自N、O、S和Se的群体）的C1-12杂环环系统；R2是C1-12有机基团；R7、R8各自独立地是氢（H）、羟基、氧代（即羰基）、C1-8烷基、C1-8烷氧基、C2-8烯基、C2-10炔基、C5-7环烷基、C5-7环烯基、卤素、C1-4醛基或—NR4q，其中R4是H、C1-8烷基、C2-8烯基、C4-8环烷基、C4-8环烯基或C6-10芳基；o为0、1、2、3或4；A是C6-12芳基、C5-12杂芳基或可选地取代的3-羟基吡啶-4（1H）-酮；p为1到6的整数；Zm是缺席或二价连接基；m是代表Z重复次数的整数。
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  DOI：10.1016/j.bmc.2016.08.021

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