2-Methoxy-isoflavon | 26964-33-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异黄酮类化合物
• 英文名称: 2-Methoxy-isoflavon
• 英文别名: 2-methoxy-3-phenyl-chromen-4-one；2-Methoxy-3-phenyl-chromen-4-on；2-Methoxy-3-phenylchromen-4-one
• CAS: 26964-33-0
• 化学式: C₁₆H₁₂O₃
• 分子量: 252.269
• InChiKey: HVSVZCQKJSROSY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  重氮甲烷 、 3-phenyl-chroman-2,4-dione 在 乙醚 作用下， 生成 4-methoxy-3-phenylcoumarin 、 2-Methoxy-isoflavon
  参考文献：
  名称：

  Cieslak et al., Roczniki Chemii, 1959, vol. 33, p. 349,351

  摘要：

  DOI：

文献信息

• CALYCOSIN AND ANALOGS THEREOF FOR THE TREATMENT OF ESTROGEN RECEPTOR BETA-MEDIATED DISEASES
  申请人：Cohen Isaac

  公开号：US20090258942A1

  公开（公告）日：2009-10-15

  Estrogenic compositions comprising calycosin and analogs thereof are provided. Also provided are methods of using said extracts to achieve an estrogenic effect, especially in a human, e.g. a female human. In some embodiments, the methods include treatment of climacteric symptoms. In some embodiments, the methods include treatment of estrogen receptor positive cancer, such as estrogen responsive breast cancer. In some embodiments, the methods include treatment or prevention of osteoporosis.

  提供了含有紫葳素及其类似物的雌激素组合物。还提供了使用该提取物以实现雌激素作用的方法，特别是在人体中，例如女性。在某些实施例中，该方法包括治疗更年期症状。在某些实施例中，该方法包括治疗雌激素受体阳性的癌症，如雌激素反应性乳腺癌。在某些实施例中，该方法包括治疗或预防骨质疏松症。
• [EN] HAIR GROWTH STIMULANT AND PREPARATION METHOD THEREOF<br/>[FR] STIMULANT DE POUSSE CAPILLAIRE ET SON PROCÉDÉ DE PRÉPARATION
  申请人：DELTAHEX INNOVATION PVT LTD

  公开号：WO2017068604A1

  公开（公告）日：2017-04-27

  The present invention provides a novel compound of Formula-I, process for preparation of the same, composition comprising of the same and use of these compounds for prevention of hair fall and restoration of hair growth cycle.

  本发明提供了一种新颖的化合物I的配方，其制备方法，包含该化合物的组合物以及使用这些化合物预防脱发和恢复头发生长周期。
• Hair loss compositions and methods of making and using same
  申请人：The Beauty Cartel, LLC

  公开号：US10226495B2

  公开（公告）日：2019-03-12

  A composition for promoting hair growth comprises hinoki oil, red clover extract, and a peptide. The hinoki oil can comprise from about 0.01% to about 5% by weight of the composition, the red clover extract can comprise from about 1 ppmw to about 1,000 ppmw of the composition, and the peptide can comprise from about 0.01 ppmw to about 500 ppmw of the composition.

  一种促进头发生长的组合物由桧木油、红三叶草提取物和一种肽组成。按重量计，桧油可占组合物的约 0.01% 至约 5%，红三叶草提取物可占组合物的约 1 ppmw 至约 1,000 ppmw，肽可占组合物的约 0.01 ppmw 至约 500 ppmw。
• Bioactive fractions and compounds from Dalbergia sissoo for the prevention or treatment of osteo-health related disorders
  申请人：Maurya Rakesh

  公开号：US10292994B2

  公开（公告）日：2019-05-21

  The present invention relates to bioactive fractions and compounds from Dalbergia sissoo for the prevention or treatment of osteo-health related disorders. The present invention relates in the field of pharmaceutical composition that provides new plant extracts, their fractions and pure compound isolated from natural sources that are useful for the prevention and/or treatment of various medical indications associated with estrogen dependent or independent diseases or syndromes or disorders preferably in the prevention or treatment of estrogen dependent or independent diseases or syndromes or disorders caused in humans and animals, and achievement of peak bone mass during skeletal growth and health in humans and animals. Particularly the present invention further relates to the processes for the preparation of biologically active extracts, fractions, and isolation of pure compounds, from Dalbergia sissoo plant from the family Fabaceae their pharmaceutically acceptable salts and compositions of the principal aspect of the present invention.

  本发明涉及用于预防或治疗骨健康相关疾病的 Dalbergia sissoo 的生物活性馏分和化合物。本发明涉及药物组合物领域，提供了新的植物提取物、其馏分和从天然来源分离的纯化合物，这些提取物、馏分和纯化合物可用于预防和/或治疗与雌激素依赖性或独立疾病或综合症或紊乱有关的各种医学指征，优选用于预防或治疗人类和动物引起的雌激素依赖性或独立疾病或综合症或紊乱，以及在人类和动物骨骼生长和健康过程中达到峰值骨量。特别是本发明进一步涉及从豆科植物Dalbergia sissoo中制备生物活性提取物、馏分和分离纯化合物的工艺，它们是本发明主要方面的药学上可接受的盐和组合物。
• Non-steroidal anabolic compositions and associated methods
  申请人：Lifesmart Nutrition, Inc.

  公开号：US20020187179A1

  公开（公告）日：2002-12-12

  The present invention provides a non-steroidal anabolic formulation which reduces or eliminates an objectionable isoflavone taste, while simultaneously increasing the efficiency of an isoflavone dose. In one aspect, an effective amount of methoxyflavone, and optionally an effective amount of ipriflavone, are uniformly dispersed in a caramel or taffy composition having an insulin level enhancing amount of sugar. In another aspect, the caramel composition may include an effective amount of an invert sugar.

  本发明提供了一种非甾体类合成代谢制剂，它可以减少或消除令人反感的异黄酮味道，同时提高异黄酮剂量的效率。在一个方面，有效量的甲氧基黄酮和可选的有效量的异黄酮均匀地分散在具有提高胰岛素水平的糖量的焦糖或太妃糖组合物中。在另一方面，焦糖组合物可以包括有效量的转化糖。