(4Z,9Z)-(1S,3aS,8S)-1-Isopropyl-3a,8-dimethyl-4-[2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl]-1,2,3,3a,7,8-hexahydro-cyclopentacycloocten-6-one | 131935-05-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (4Z,9Z)-(1S,3aS,8S)-1-Isopropyl-3a,8-dimethyl-4-[2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl]-1,2,3,3a,7,8-hexahydro-cyclopentacycloocten-6-one
• CAS: 131935-05-2
• 化学式: C₂₂H₃₄O₃
• 分子量: 346.51
• InChiKey: HJSKNSYBUPUVDO-VMRPIFDYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.06
• 重原子数：
  25.0
• 可旋转键数：
  4.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  35.53
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  (4Z,9Z)-(1S,3aS,8S)-1-Isopropyl-3a,8-dimethyl-4-[2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl]-1,2,3,3a,7,8-hexahydro-cyclopentacycloocten-6-one 在 palladium on activated charcoal 盐酸 、 氢气 作用下， 以 乙醇 为溶剂， 反应 4.0h， 生成 (3aS,4R,8R)-1-Isopropyl-3a,8-dimethyl-4-(3-oxo-butyl)-2,3,3a,4,5,7,8,9-octahydro-cyclopentacycloocten-6-one
  参考文献：
  名称：

  Synthetic studies on basmane diterpenes. Enantiospecific total synthesis of (+)-7,8-epoxy-2-basmen-6-one by Claisen ring expansion

  摘要：

  The first synthesis of an epoxybasmenone is described. The enantiospecific pathway begins by transforming optically pure aldehyde 10 into bicyclic lactone 39. Methylenation of 39 by means of the Tebbe reaction allows for operation of a Claisen rearrangement that proceeds almost completely by way of chair transition state 44 to give the cyclooctadienone 42. Regiospecific cyclopentannulation with installation of four additional stereogenic centers rested upon successful introduction of a functionalized four-carbon chain as in 48, facially controlled hydrogenation of the conjugated double bond, cyclization, and hydroxyl-directed epoxidation. Finally, Swern oxidation led to the target molecule 3, whose three-dimensional structural features were confirmed by X-ray crystallography.

  DOI：

  10.1021/ja00007a039
• 作为产物：
  描述：

  (4aS,7S,7aS)-5,6,7,7a-tetrahydro-7-isopropyl-4a-methyl-7a-propenylcyclopentapyran-2(4aH)-one 在 吡啶 、 苯基氯化硒 、 双氧水 作用下， 以 四氢呋喃 、 甲苯 、 苯 为溶剂， 反应 26.83h， 生成 (4Z,9Z)-(1S,3aS,8S)-1-Isopropyl-3a,8-dimethyl-4-[2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl]-1,2,3,3a,7,8-hexahydro-cyclopentacycloocten-6-one
  参考文献：
  名称：

  Synthetic studies on basmane diterpenes. Enantiospecific total synthesis of (+)-7,8-epoxy-2-basmen-6-one by Claisen ring expansion

  摘要：

  The first synthesis of an epoxybasmenone is described. The enantiospecific pathway begins by transforming optically pure aldehyde 10 into bicyclic lactone 39. Methylenation of 39 by means of the Tebbe reaction allows for operation of a Claisen rearrangement that proceeds almost completely by way of chair transition state 44 to give the cyclooctadienone 42. Regiospecific cyclopentannulation with installation of four additional stereogenic centers rested upon successful introduction of a functionalized four-carbon chain as in 48, facially controlled hydrogenation of the conjugated double bond, cyclization, and hydroxyl-directed epoxidation. Finally, Swern oxidation led to the target molecule 3, whose three-dimensional structural features were confirmed by X-ray crystallography.

  DOI：

  10.1021/ja00007a039