3-(2-benzyloxy-4-fluorophenyl)-2-chloro-4-hydroxy-5-phenyl-6,7-dihydro-thieno[2,3-b]pyridin-6-one | 1190767-12-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异黄酮类化合物
• 英文名称: 3-(2-benzyloxy-4-fluorophenyl)-2-chloro-4-hydroxy-5-phenyl-6,7-dihydro-thieno[2,3-b]pyridin-6-one
• 英文别名: 2-chloro-3-(4-fluoro-2-phenylmethoxyphenyl)-4-hydroxy-5-phenyl-7H-thieno[2,3-b]pyridin-6-one
• CAS: 1190767-12-4
• 化学式: C₂₆H₁₇ClFNO₃S
• 分子量: 477.943
• InChiKey: OAOCTRZECSMFFF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  33
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  86.8
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• THIENOPYRIDONE DERIVATIVES AS AMP-ACTIVATED PROTEIN KINASE (AMPK) ACTIVATORS
  申请人：Cravo Daniel

  公开号：US20110034505A1

  公开（公告）日：2011-02-10

  The present invention relates to compounds of formula (I) wherein R1, R2 and R3 are as defined in claim 1 , including pharmaceutical compositions thereof and for their use in the treatment and/or prevention of diseases and disorders modulated by AMP agonists. The invention is also directed to intermediates and to a method of preparation of compounds of formula (I).

  本发明涉及式（I）化合物，其中R1、R2和R3如权利要求1所定义，包括其药物组合物以及用于治疗和/或预防由AMP激动剂调节的疾病和紊乱的用途。该发明还涉及中间体和式（I）化合物的制备方法。
• US8563729B2
  申请人：——

  公开号：US8563729B2

  公开（公告）日：2013-10-22