2-(5-acetylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-{2,3-dioxo-1-phenylmethyl-6-(2-pyridyloxy)}hexylacetamide | 204460-26-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮
• 英文名称: 2-(5-acetylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-{2,3-dioxo-1-phenylmethyl-6-(2-pyridyloxy)}hexylacetamide
• 英文别名: 2-(5-acetamido-6-oxo-2-phenylpyrimidin-1-yl)-N-(3,4-dioxo-1-phenyl-7-pyridin-2-yloxyheptan-2-yl)acetamide
• CAS: 204460-26-4
• 化学式: C₃₂H₃₁N₅O₆
• 分子量: 581.628
• InChiKey: WHENVNQDVRXYKS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  43
• 可旋转键数：
  14
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  147
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• Novel remedies or preventives for angiostenosis
  申请人：——

  公开号：US20040019068A1

  公开（公告）日：2004-01-29

  The present invention relates to a therapeutic or prophylactic agent for an angiostenosis comprising as an active ingredient a compound having a pyrimidone skeleton and having chymase inhibiting activity, for example, a compound having a structure represented by the following Formula (II) 1 and having high selective chymase inhibiting activity or a pharmacologically acceptable salt thereof.

  本发明涉及一种治疗或预防血管狭窄的药物或预防剂，其活性成分为具有嘧啶酮骨架并具有chymase抑制活性的化合物，例如，具有以下式（II）1表示的结构并具有高选择性chymase抑制活性或其药理学上可接受的盐。
• NOVEL ACETAMIDE DERIVATIVES AND PROTEASE INHIBITORS
  申请人：NIPPON KAYAKU KABUSHIKI KAISHA

  公开号：EP0936216A1

  公开（公告）日：1999-08-18

  The present invention relates to novel acetamide derivatives having a substituted heterocyclic group and consecutive dicarbonyl structures, for example 1-pyrimidinylacetamide compounds, 1-pyrazinylacetamide compounds, 1-triazinylacetamide compounds etc., and these compounds have inhibitory activity on chymotrypsin type proteases and are useful as inhibitors for said enzymes, particularly as chymase inhibitors. The novel acetamide derivatives of the present invention are shown in formula (I) below: wherein R0 is substituted or unsubstituted phenyl; R1 is aryl, heteroaryl or aliphatic lower alkyl which may be substituted or unsubstituted; R2 is substituted or unsustituted alkyl, arylalkyl, or heteroarylalkyl; R3 is hydrogen; acyl group; sulfonyl group; isocyanate group; thiourea; or hydrogen, a lower alkyl or a substituted lower alkyl; aryl (1-7C) alkyl, heteroaryl (1-7C) alkyl, aryl and heteroaryl; X and Y independently represent a nitrogen atom or a carbon atom; and Z is a polymethylene group wherein a hydrogen atom in the polymethylene may be replaced.

  本发明涉及具有取代杂环基团和连续二羰基结构的新型乙酰胺衍生物，例如1-嘧啶基乙酰胺化合物、1-吡嗪基乙酰胺化合物、1-三嗪基乙酰胺化合物等，这些化合物对糜蛋白酶型蛋白酶具有抑制活性，可用作上述酶的抑制剂，特别是糜蛋白酶抑制剂。本发明的新型乙酰胺衍生物如下式(I)所示： 其中 R0 是取代或未取代的苯基；R1 是芳基、杂芳基或可取代或未取代的脂肪族低级烷基；R2 是取代或未取代的烷基、芳烷基或杂芳基；R3 是氢；酰基；磺酰基；异氰酸酯基；硫脲；或氢、低级烷基或取代的低级烷基；芳基（1-7C）烷基、杂芳基（1-7C）烷基、芳基和杂芳基； X 和 Y 独立地代表一个氮原子或一个碳原子；Z 是一个聚亚甲基，其中聚亚甲基中的一个氢原子可被取代。
• US6271238B1
  申请人：——

  公开号：US6271238B1

  公开（公告）日：2001-08-07