The present invention provides a method for determining the oxygen status of a cancer of an individual. The method comprise determining the transcriptional expression level of ADM (SEQ ID No:1), and/or at least one gene selected from ANKRD37 (SEQ ID NO.: 3), P4HA2 (SEQ ID NO.: 12), NDRG1 (SEQ ID NO: 10), SLC2A1 (SEQ ID NO:15), P4HA1 (SEQ ID NO.: 11), LOX (SEQ ID NO.: 9), C3orf28 (SEQ ID NO.: 6), BNIP3L (SEQ ID NO.: 5), BNIP3 (SEQ ID NO.:4), EGLN3 (SEQ ID NO.: 7), PDK1 (SEQ ID NO.: 13), PFKFB3 (SEQ ID NO.: 14), KCTD11 (SEQ ID NO.: 8), and/or ALDOA (SEQ ID NO.: 2), in a cancer sample. The transcriptional level is then correlated to the transcriptional level to at least one reference gene, and oxygen status 10 is then evaluated by comparing the correlated transcription level with a predetermined reference sample comprising cancer cells characterized by a high oxygen level.
本发明提供了一种确定个体癌症氧状态的方法。该方法包括确定 A
DM(
SEQ ID No:1)和/或至少一个选自 ANKRD37(
SEQ ID NO.:11)、LOX(
SEQ ID NO.:9)、C3orf28(
SEQ ID NO.:6)、BNIP3L(
SEQ ID NO.:5)、BNIP3(
SEQ ID NO.:4)、
EGLN3(
SEQ ID NO.:7)、PDK1(
SEQ ID NO.:13)、PFKFB3(
SEQ ID NO.:14)、KCTD11(
SEQ ID NO.:8)和/或 AL
DOA(
SEQ ID NO.:2)。然后将转录
水平与至少一个参考
基因的转录
水平相关联,再通过将相关联的转录
水平与预定的参考样本(包括以高氧
水平为特征的癌细胞)进行比较来评估氧状态 10。