Bis-{6-[(1R,2S,3R,6S)-2,3-O-isopropylidenecyclohex-4-ene-1,2,3-triol]}amine O-diacetate | 350032-63-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Bis-{6-[(1R,2S,3R,6S)-2,3-O-isopropylidenecyclohex-4-ene-1,2,3-triol]}amine O-diacetate
• 英文别名: [(3aR,4R,5S,7aR)-5-[[(3aR,4R,5S,7aR)-4-acetyloxy-2,2-dimethyl-3a,4,5,7a-tetrahydro-1,3-benzodioxol-5-yl]amino]-2,2-dimethyl-3a,4,5,7a-tetrahydro-1,3-benzodioxol-4-yl] acetate
• CAS: 350032-63-2
• 化学式: C₂₂H₃₁NO₈
• 分子量: 437.49
• InChiKey: DDPSLHHGVOTVIS-IFLAPALPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.36
• 重原子数：
  31.0
• 可旋转键数：
  4.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  101.55
• 氢给体数：
  1.0
• 氢受体数：
  9.0

反应信息

• 作为反应物：
  描述：

  Bis-{6-[(1R,2S,3R,6S)-2,3-O-isopropylidenecyclohex-4-ene-1,2,3-triol]}amine O-diacetate 在 吡啶 、 四氧化锇 、 2-氯-N-(2-氯乙基)-N-甲基乙胺氧化物 、 sodium methylate 、 对甲苯磺酸 作用下， 以 甲醇 、 二氯甲烷 、 水 、 丙酮 、 叔丁醇 为溶剂， 反应 70.0h， 生成 (3aS,3a'S,4R,4'R,5R,5aS,5'R,5a'S,8aS,8bS,8a'S,8b'S)-5,5'-azanediylbis(2,2,7,7-tetramethylhexahydrobenzo[1,2-d:3,4-d']bis([1,3]dioxole)-4-ol)
  参考文献：
  名称：

  Paul, Bernhard J.; Martinot, Theodore A.; Willis, Jerremey, Synthesis, 2001, # 6, p. 952 - 956

  摘要：

  DOI：
• 作为产物：
  描述：

  [3aS-(3aα,5aβ,6aβ,6bα)]-4-溴-3a,5a,6a,6b-四氢-2,2-二甲基环氧乙烷并[e]-1,3-苯并二茂 在 吡啶 、 4-二甲氨基吡啶 、 偶氮二异丁腈 、 氨 、 三正丁基氢锡 、 ytterbium(III) triflate 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 23.5h， 生成 Bis-{6-[(1R,2S,3R,6S)-2,3-O-isopropylidenecyclohex-4-ene-1,2,3-triol]}amine O-diacetate
  参考文献：
  名称：

  Paul, Bernhard J.; Martinot, Theodore A.; Willis, Jerremey, Synthesis, 2001, # 6, p. 952 - 956

  摘要：

  DOI：

文献信息

• Synthesis, Structure, and Biological Evaluation of Novel <i>N</i>- and <i>O</i>-Linked Diinositols
  作者：Bernhard J. Paul、Jerremey Willis、Theodore A. Martinot、Ion Ghiviriga、Khalil A. Abboud、Tomas Hudlicky

  DOI：10.1021/ja0205378

  日期：2002.9.1

  Several O-and N-linked inositols and/or aminoinositols have been prepared by iterative opening of epoxides and aziridines derived from homochiral cyclohexadiene cis-diols. The three inositols and their intermediate conduritols (conduramines) were tested against several glycosiclases (alpha- and beta-glucosidase, alpha- and beta-galactosidase, alpha- and beta-mannosidase) in an assay that measured the rate of hydrolysis of p-nitrophenolglycosides rather than the concentration of p-nitrophenolate. Somewhat surprisingly, the best inhibition was seen against beta-galactosidase with several of the compounds. The inositols linked through oxygen or nitrogen were subjected to calcium binding studies performed in NMR experiments. Detailed analysis of the title compounds by NMR spectroscopy has been performed, and full assignments were made. One of the attendant benefits of the preparation of these compounds has been expressed in the design and synthesis of new salen catalysts whose effectiveness has been compared with Jacobsen's catalyst in the epoxidation of styrene.