2-(methoxymethyl)-5-(3-benzoylpyrrol-1-yl)benzaldehyde | 1615685-39-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(methoxymethyl)-5-(3-benzoylpyrrol-1-yl)benzaldehyde
• CAS: 1615685-39-6
• 化学式: C₂₀H₁₇NO₃
• 分子量: 319.36
• InChiKey: XBVCYHXDSCEVOA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.67
• 重原子数：
  24.0
• 可旋转键数：
  6.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  48.3
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  2-(methoxymethyl)-5-(3-benzoylpyrrol-1-yl)benzaldehyde 在 三溴化硼 作用下， 以 二氯甲烷 、 甲醇 为溶剂， 生成 5-(3-benzoylpyrrol-1-yl)-2-hydroxymethylbenzaldehyde 、 [1-(3-Hydroxy-1,3-dihydro-2-benzofuran-5-yl)pyrrol-3-yl]-phenylmethanone
  参考文献：
  名称：

  Novel pyrrolobenzoxaboroles: Design, synthesis, and biological evaluation against Trypanosoma brucei

  摘要：

  Human African trypanosomiasis is a fatal parasitic infection caused by the protozoan Trypanosoma brucei. The development of novel antitrypanosomal agents is urgently needed. Here we report the synthesis and structure-activity relationship of a new class of benzoxaboroles as antitrypanosomal agents. These compounds showed antiparasitic IC50 values ranging from 4.02 to 0.03 mu g/mL and satisfactory cytotoxicity profile. Three of the lead compounds were demonstrated to cure the parasitic infection in a murine acute infection model. The structure activity relationship of the pyrrolobenzoxaboroles are also discussed. (C) 2014 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2014.04.079
• 作为产物：
  描述：

  2-溴-4-硝基苯甲酰氯 在 sodium tetrahydroborate 、 锂硼氢 、 正丁基锂 、 tin(II) chloride dihdyrate 、 四氯化锡 、 sodium hydride 、 三乙胺 、 pyridinium chlorochromate 、 sodium hydroxide 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 水 、 乙酸乙酯 、 mineral oil 为溶剂， 反应 18.17h， 生成 2-(methoxymethyl)-5-(3-benzoylpyrrol-1-yl)benzaldehyde
  参考文献：
  名称：

  Novel pyrrolobenzoxaboroles: Design, synthesis, and biological evaluation against Trypanosoma brucei

  摘要：

  Human African trypanosomiasis is a fatal parasitic infection caused by the protozoan Trypanosoma brucei. The development of novel antitrypanosomal agents is urgently needed. Here we report the synthesis and structure-activity relationship of a new class of benzoxaboroles as antitrypanosomal agents. These compounds showed antiparasitic IC50 values ranging from 4.02 to 0.03 mu g/mL and satisfactory cytotoxicity profile. Three of the lead compounds were demonstrated to cure the parasitic infection in a murine acute infection model. The structure activity relationship of the pyrrolobenzoxaboroles are also discussed. (C) 2014 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2014.04.079