Organocatalytic asymmetric domino Michael–Henry reaction for the synthesis of substituted bicyclo[3.2.1]octan-2-ones
作者:Michail Tsakos、Mark R. J. Elsegood、Christoforos G. Kokotos
DOI:10.1039/c3cc39165e
日期:——
The first organocatalyticasymmetricreaction between 1,4-cyclohexanedione and nitroalkenes has been studied, affording bicyclo[3.2.1]octane derivatives containing four continuous stereogenic centres. The products were obtained through a domino Michael-Henry process as a single diastereoisomer with excellent enantioselectivities.