methyl 2-[(2R,3R,4S,5S,6R)-2-[(2R,3R,4R,5R,6S)-5-acetamido-3-hydroxy-2-(hydroxymethyl)-6-methoxyoxan-4-yl]oxy-3,5-bis[(2-chloroacetyl)oxy]-6-[(2-chloroacetyl)oxymethyl]oxan-4-yl]oxyacetate | 316139-78-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: methyl 2-[(2R,3R,4S,5S,6R)-2-[(2R,3R,4R,5R,6S)-5-acetamido-3-hydroxy-2-(hydroxymethyl)-6-methoxyoxan-4-yl]oxy-3,5-bis[(2-chloroacetyl)oxy]-6-[(2-chloroacetyl)oxymethyl]oxan-4-yl]oxyacetate
• CAS: 316139-78-3
• 化学式: C₂₄H₃₄Cl₃NO₁₆
• 分子量: 698.89
• InChiKey: HJTGJZBOEHTMOA-RAJUIIOUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  44
• 可旋转键数：
  19
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  221
• 氢给体数：
  3
• 氢受体数：
  16

反应信息

• 作为反应物：
  描述：

  Phenyl O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-(1->4)-O-<(2,3,4-tri-O-benzyl-α-L-fucopyranosyl)-(1->3)>-6-O-benzyl-2-deoxy-2-phthalimido-1-thio-β-D-glucopyranoside 、 methyl 2-[(2R,3R,4S,5S,6R)-2-[(2R,3R,4R,5R,6S)-5-acetamido-3-hydroxy-2-(hydroxymethyl)-6-methoxyoxan-4-yl]oxy-3,5-bis[(2-chloroacetyl)oxy]-6-[(2-chloroacetyl)oxymethyl]oxan-4-yl]oxyacetate 在 N-碘代丁二酰亚胺 、 三氟甲磺酸 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以45%的产率得到
  参考文献：
  名称：

  Chemical synthesis of a core 2 branched pentasaccharide containing a carboxylate group

  摘要：

  Design and synthesis of a carboxylate-containing pentasaccahride 1 with the Gal beta>(*) over bar * (1-4) (Fuc alpha1-3)GlcNAc beta>(*) over bar *( 1-6){3-[1-carboxymethyl]-Gal beta>(*) over bar * (1-3)} GalNAc alpha -OMe sequence, which is obtained through regioselective coupling of the 6-OH of a novel acceptor 9 with Lewis(x) donor 10 catalyzed by NIS-TfOH are described. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00497-2
• 作为产物：
  描述：

  O-甲基-N-乙酰基-2-脱氧-alpha-D-半乳糖胺 在 sodium methylate 、 氰化汞 、 4-甲基苯磺酸吡啶 、 二正丁基氧化锡 、 碳酸氢钠 、 溶剂黄146 作用下， 以 甲醇 、 硝基甲烷 、 二氯甲烷 、 N,N-二甲基甲酰胺 、 乙腈 、 苯 为溶剂， 反应 90.0h， 生成 methyl 2-[(2R,3R,4S,5S,6R)-2-[(2R,3R,4R,5R,6S)-5-acetamido-3-hydroxy-2-(hydroxymethyl)-6-methoxyoxan-4-yl]oxy-3,5-bis[(2-chloroacetyl)oxy]-6-[(2-chloroacetyl)oxymethyl]oxan-4-yl]oxyacetate
  参考文献：
  名称：

  Chemical synthesis of a core 2 branched pentasaccharide containing a carboxylate group

  摘要：

  Design and synthesis of a carboxylate-containing pentasaccahride 1 with the Gal beta>(*) over bar * (1-4) (Fuc alpha1-3)GlcNAc beta>(*) over bar *( 1-6){3-[1-carboxymethyl]-Gal beta>(*) over bar * (1-3)} GalNAc alpha -OMe sequence, which is obtained through regioselective coupling of the 6-OH of a novel acceptor 9 with Lewis(x) donor 10 catalyzed by NIS-TfOH are described. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00497-2

文献信息

• Chemical synthesis of a core 2 branched pentasaccharide containing a carboxylate group
  作者：Jie Xia、James L. Alderfer、Khushi L. Matta

  DOI：10.1016/s0960-894x(00)00497-2

  日期：2000.11

  Design and synthesis of a carboxylate-containing pentasaccahride 1 with the Gal beta>(*) over bar * (1-4) (Fuc alpha1-3)GlcNAc beta>(*) over bar *( 1-6)3-[1-carboxymethyl]-Gal beta>(*) over bar * (1-3)} GalNAc alpha -OMe sequence, which is obtained through regioselective coupling of the 6-OH of a novel acceptor 9 with Lewis(x) donor 10 catalyzed by NIS-TfOH are described. (C) 2000 Elsevier Science Ltd. All rights reserved.