2,2-di(prop-2-yn-1-yl)propane-1,3-diyl bis(trifluoromethanesulfonate) | 1352039-17-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: 2,2-di(prop-2-yn-1-yl)propane-1,3-diyl bis(trifluoromethanesulfonate)
• CAS: 1352039-17-8
• 化学式: C₁₁H₁₀F₆O₆S₂
• 分子量: 416.319
• InChiKey: GBGNNDSWQRYOQI-UHFFFAOYSA-N

物化性质

• 沸点：
  428.6±45.0 °C(Predicted)
• 密度：
  1.569±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.75
• 重原子数：
  25.0
• 可旋转键数：
  8.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  86.74
• 氢给体数：
  0.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  2,2-di(prop-2-yn-1-yl)propane-1,3-diyl bis(trifluoromethanesulfonate) 在 sodium azide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.5h， 以95%的产率得到4,4-Bis(azidomethyl)hepta-1,6-diyne
  参考文献：
  名称：

  Synthesis of spiro bis(1,2,3-triazolium) salts as chiral ionic liquids

  摘要：

  Unique chiral spiro ionic liquids based on 1,2,3-triazolium salts were synthesized via an intramolecular double Huisgen reaction. The optical resolution of the liquid precursors and subsequent dialkylations leads to chiral spiro triazolium salts on a gram scale. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.09.152
• 作为产物：
  描述：

  二甲基-2.2-二(丙-2-炔基)丙二酸二乙酯 在 吡啶 、 4-二甲氨基吡啶 、 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 2,2-di(prop-2-yn-1-yl)propane-1,3-diyl bis(trifluoromethanesulfonate)
  参考文献：
  名称：

  通过分子内[3+2]环加成酸促进无金属合成三唑稠杂环化合物

  摘要：

  A practical and efficient protocol for the synthesis of triazole-fused heterocycles through intramolecular metal free [3+2] azide-alkyne cycloaddition reaction is described. Range of acids was selected to demonstrate the reaction conditions. Organic azides and propargyl cations generated by acids gave fused triazoles including multivariate rings and heterocycles. Various fused triazoles and bistriazoles were obtained in good yields under mild reaction conditions.

  DOI：

  10.3987/com-18-13900

文献信息

• [EN] CEREBLON LIGANDS<br/>[FR] LIGANDS DE CÉRÉBLON
  申请人：UNIV MICHIGAN REGENTS

  公开号：WO2022187423A1

  公开（公告）日：2022-09-09

  The present disclosure provides compounds of Formula (I), wherein A, A1, A2, A3, R3, Z and Z1are as defined in the specification, and the salts and solvates thereof. The present disclosure also relates to uses of the compounds as cereblon (CRBN) ubiquitination inhibitors, as synthetic intermediates that can be used to prepare PROTAC molecules, or as PROTAC molecules. The present disclosure also relates to uses of the compounds, e.g., in treating or preventing cancer and other diseases.

  本公开提供式（I）的化合物，其中A、A1、A2、A3、R3、Z和Z1如规范中所定义，并且其盐和溶剂化物。本公开还涉及将该化合物用作 cereblon（CRBN）泛素化抑制剂，用作可用于制备PROTAC分子的合成中间体，或用作PROTAC分子的用途。本公开还涉及将该化合物用于治疗或预防癌症和其他疾病的用途。
• Design and synthesis of spiro bis(1,2,3-triazolium) salts as chiral ionic liquids
  作者：Yasushi Yoshida、Shinobu Takizawa、Hiroaki Sasai

  DOI：10.1016/j.tetasy.2012.06.007

  日期：2012.6

  Room temperature chiral spiro ionic liquids 1 and 2 based on 1,2,3-triazolium salts, were synthesized via an intramolecular double Huisgen reaction. The preparation of the enantiomerically pure Spiro triazolium salts was achieved by resolution by HPLC using a chiral stationary phase column and subsequent N-dial-kylations of spiro triazoles 6 and 10. (c) 2012 Elsevier Ltd. All rights reserved.