4-氨基喹啉-2-羧酸 | 157915-66-7

• 物质功能分类: 生物化工 - 氨基酸及其衍生物 - 其他氨基酸衍生物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 4-氨基喹啉-2-羧酸
• 英文名称: 4-Amino-2-quinoline carboxylic acid
• 英文别名: 4-aminoquinolinecarboxylic acid；4-amino-quinoline-2-carboxylic acid；4-Amino-chinolin-2-carbonsaeure；4-Aminoquinoline-2-carboxylic acid
• CAS: 157915-66-7
• 化学式: C₁₀H₈N₂O₂
• mdl: MFCD00160594
• 分子量: 188.186
• InChiKey: GCZKIAHUIXWOGS-UHFFFAOYSA-N

物化性质

• 沸点：
  445.6±40.0 °C(Predicted)
• 密度：
  1.430±0.06 g/cm3(Predicted)
• 溶解度：
  可溶于DMSO（轻微、加热、超声处理）、甲醇（轻微）

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  76.2
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 海关编码：
  2933499090

反应信息

• 作为反应物：
  描述：

  4-氨基喹啉-2-羧酸 、 1-{1-[(3-phenyl-5-isoxazolyl)methyl]-4-piperidinyl}methanamine 生成 4-amino-N-((1-((3-phenylisoxazol-5-yl)methyl)piperidin-4-yl)methyl)quinoline-2-carboxamide
  参考文献：
  名称：

  Piperidine-containing compounds and use thereof

  摘要：

  本发明提供了一种预防和/或治疗代谢性疾病、脑血管疾病等的方法，包括向哺乳动物施用化合物(I)的有效量：其中所有符号的含义均如规范中所定义；其盐、N-氧化物、溶剂化物或前药。化合物(I-1)的新型化合物：其中所有符号的含义均如规范中所定义；其盐、N-氧化物、溶剂化物或前药具有抗糖尿病和神经保护作用。因此，化合物(I)和化合物(I-1)在预防和/或治疗代谢性疾病如糖尿病、脑血管疾病如中风等方面是有用的。

  公开号：

  US08809538B2
• 作为产物：
  描述：

  4-acetylamino-quinoline-2-carboxylic acid 在 硫酸 作用下， 生成 4-氨基喹啉-2-羧酸
  参考文献：
  名称：

  386. 4-氨基-2-苯乙烯基喹啉及一些相关化合物的制备

  摘要：

  DOI：

  10.1039/jr9490001803

文献信息

• [EN] PIPERIDINE-CONTAINING COMPOUNDS AND USE THEREOF<br/>[FR] COMPOSÉS CONTENANT DE LA PIPÉRIDINE ET LEURS UTILISATIONS
  申请人：ARRAY BIOPHARMA INC

  公开号：WO2010080864A1

  公开（公告）日：2010-07-15

  A method for preventing and/or treating a metabolic disease, cerebrovascular disease, etc. which comprises administering to a mammal an effective amount of the compound of the formula (I) wherein all symbols have the same meanings as defined in the specification; a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof. And a novel compound of the formula (I-1): wherein all symbols have the same meanings as defined in the specification; a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof has an anti-diabetic effect and a neuroprotective effect. Accordingly, the compound of the formula (I) and the compound of the formula (I-1) are useful in a method for preventing and/or treating for a metabolic disease such as diabetes, cerebrovascular disease such as stroke, etc.

  一种预防和/或治疗代谢性疾病、脑血管疾病等的方法，包括向哺乳动物施用化合物的有效量，其化学式为(I)，其中所有符号的含义与规范中定义的相同；其盐、N-氧化物、溶剂合物或前药。以及化学式(I-1)的新化合物：其中所有符号的含义与规范中定义的相同；其盐、N-氧化物、溶剂合物或前药具有抗糖尿病作用和神经保护作用。因此，化合物(I)和化合物(I-1)在预防和/或治疗代谢性疾病如糖尿病、脑血管疾病如中风等方面是有用的。
• Inhibitors of the GPib - vWF interaction
  申请人：Aventis Pharma Deutschland GmbH

  公开号：EP1369420A1

  公开（公告）日：2003-12-10

  The present invention relates to compounds of the formula I, in which R1, R2, A, B, D, E, n, m or o have the meanings indicated below. The compounds of the formula I are valuable pharmacologically active compounds. They are reversible inhibitors of the interaction between the plasma protein von Willebrand factor (vWF) and the blood platelet receptor glycoprotein Ib-IX-V complex (GPIb). They exhibit an antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of athero-thrombotic diseases.

  本发明涉及式I的化合物，其中R1、R2、A、B、D、E、n、m或o具有下面指示的含义。式I的化合物是有价值的药理活性化合物。它们是血浆蛋白冯·威尔布兰因子（vWF）与血小板受体糖蛋白Ib-IX-V复合物（GPIb）之间相互作用的可逆抑制剂。它们表现出抗血栓作用，例如适用于动脉-血栓性疾病的治疗和预防。
• Carbapenem antibiotic compounds
  申请人：Zeneca Limited

  公开号：US05441949A1

  公开（公告）日：1995-08-15

  The present invention relates to carbapenems and provides a compound of the formula (I) ##STR1## wherein: R.sup.1 is 1-hydroxyethyl, 1-fluoroethyl or hydroxymethyl; R.sup.2 is hydrogen or C.sub.1-4 alkyl; R.sup.3 is hydrogen or C.sub.1-4 alkyl; P.sup.1 is of the formula: ##STR2## and one or two of A,B,C,D,E,F,G and H, are nitrogen and the remainder are CH; and P is bonded to the nitrogen of the linking carbamoyl group by a carbon atom, in either ring, is substituted by the carboxy group on a carbon atom, in either ring, and is optionally further substituted, by up to three substitutents, on a carbon atom, in either ring; or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof. Processes for their preparation, intermediates in their preparation, their use as therapeutic agents and pharmaceutical compositions containing them are also described.

  本发明涉及碳青霉烯类药物，并提供了一种具有化学式（I）的化合物 其中：R.sup.1为1-羟乙基，1-氟乙基或羟甲基；R.sup.2为氢或C.sub.1-4烷基；R.sup.3为氢或C.sub.1-4烷基；P.sup.1为以下式的一部分：并且A、B、C、D、E、F、G和H中的一个或两个为氮，其余为CH；P通过碳原子与连接的羰基基团的氮键合，在环的任一环上，均被羧基取代，或在环的任一环上，可进一步被最多三个取代基取代；或其药学上可接受的盐或体内水解酯。还描述了其制备过程，制备中间体，作为治疗剂的用途以及含有它们的药物组合物。
• Inhibitors of the GPIb-vWF interaction, their preparation and use
  申请人：——

  公开号：US20040067980A1

  公开（公告）日：2004-04-08

  The present invention relates to compounds of the formula I, 1 in which R1, R2, A, B, D, F, n, m or o have the meanings indicated below. The compounds of the formula I are valuable pharmacologically active compounds. They are reversible inhibitors of the interaction between the plasma protein von Willebrand factor (vWF) and the blood platelet receptor glycoprotein Ib-IX-V complex (GPIb). They exhibit an antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of athero-thrombotic diseases.

  本发明涉及公式I的化合物，其中R1、R2、A、B、D、F、n、m或o具有下面所示的含义。公式I的化合物是有价值的药理活性化合物。它们是血浆蛋白von Willebrand因子（vWF）和血小板受体糖蛋白Ib-IX-V复合物（GPIb）之间相互作用的可逆抑制剂。它们表现出抗血栓作用，适用于例如动脉-血栓性疾病的治疗和预防。
• PIPERIDINE-CONTAINING COMPOUNDS AND USE THEREOF
  申请人：Rodriguez Martha E.

  公开号：US20110275608A1

  公开（公告）日：2011-11-10

  A method for preventing and/or treating a metabolic disease, cerebrovascular disease, etc. which comprises administering to a mammal an effective amount of the compound of the formula (I): wherein all symbols have the same meanings as defined in the specification; a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof. And a novel compound of the formula (I-1): wherein all symbols have the same meanings as defined in the specification; a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof has an anti-diabetic effect and a neuroprotective effect. Accordingly, the compound of the formula (I) and the compound of the formula (I-1) are useful in a method for preventing and/or treating for a metabolic disease such as diabetes, cerebrovascular disease such as stroke, etc.

  一种预防和/或治疗代谢性疾病、脑血管疾病等的方法，包括向哺乳动物投与公式(I)化合物的有效量：其中所有符号的含义与规范中定义的相同；其盐、N-氧化物、溶剂化物或前药。公式(I-1)的新化合物：其中所有符号的含义与规范中定义的相同；其盐、N-氧化物、溶剂化物或前药具有抗糖尿病和神经保护作用。因此，公式(I)和公式(I-1)的化合物在预防和/或治疗代谢性疾病（如糖尿病）、脑血管疾病（如中风）等方面有用。