3-(benzo[d][1,3]dioxol-5-yl)-5,7-dihydroxy-6-(4-phenylbut-2-enyl)-4H-chromen-4-one | 1005418-27-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异黄酮类化合物
• 英文名称: 3-(benzo[d][1,3]dioxol-5-yl)-5,7-dihydroxy-6-(4-phenylbut-2-enyl)-4H-chromen-4-one
• CAS: 1005418-27-8
• 化学式: C₂₆H₂₀O₆
• 分子量: 428.441
• InChiKey: GPTKYAVMEAEXJE-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  在 盐酸 作用下， 以 甲醇 为溶剂， 生成 3-(benzo[d][1,3]dioxol-5-yl)-5,7-dihydroxy-6-(4-phenylbut-2-enyl)-4H-chromen-4-one
  参考文献：
  名称：

  Synthesis and Evaluation of Derrubone and Select Analogues

  摘要：

  [GRAPHICS]Recently, we reported that the natural product derrubone exhibits Hsp90 inhibitory activity. Due to its unique architectural scaffold and proposed rapid assembly, the synthesis of this natural product was pursued with the aim of identifying structure-activity relationships. Synthesis of the natural product was accomplished in eight highly convergent steps, which led to a facile method for the construction of related compounds. Biological evaluation of derrubone and its analogues identified several compounds that exhibit low micromolar inhibitory activity against breast and colon cancer cell lines.

  DOI：

  10.1021/jo702366g