[reaction: see text] Treatment of sugar-protected inosine and 2'-deoxyinosine derivatives with a cyclic secondary amine or imidazole and I(2)/Ph(3)P/EtN(i-Pr)(2)/(CH(2)Cl(2) or toluene) gave quantitative conversions into 6-N-(substituted)purine nucleosides. S(N)Ar reactions with 6-(imidazol-1-yl) derivatives gave 6-(N, O, or S)-substituted products. The 6-(benzylsulfonyl) group underwent S(N)Ar displacement
[反应:请参见文本]用环状仲胺或
咪唑和I(2)/ Ph(3)P / EtN(i-Pr)(2)/(CH( 2)Cl(2)或
甲苯)定量转化为6-N-(取代)
嘌呤核苷。与6-(
咪唑-1-基)衍
生物的S(N)Ar反应得到6-(N,O或S)-取代的产物。在环境温度下用芳基胺对6-(苄基磺酰基)进行S(N)Ar取代。