Bn(-3)Ido2Ac(a1-4)[CbzNH(-2d)][Bn(-3)]a-Glc1Me6Ac | 256348-55-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Bn(-3)Ido2Ac(a1-4)[CbzNH(-2d)][Bn(-3)]a-Glc1Me6Ac
• 英文别名: [(2R,3S,4R,5R,6S)-3-[(2S,3R,4S,5R,6S)-3-acetyloxy-5-hydroxy-6-(hydroxymethyl)-4-phenylmethoxyoxan-2-yl]oxy-6-methoxy-4-phenylmethoxy-5-(phenylmethoxycarbonylamino)oxan-2-yl]methyl acetate
• CAS: 256348-55-7
• 化学式: C₃₉H₄₇NO₁₄
• 分子量: 753.8
• InChiKey: ZJEFFLUMQBOFOA-VKLVNMEOSA-N

物化性质

• 沸点：
  849.2±65.0 °C(Predicted)
• 密度：
  1.33±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  54
• 可旋转键数：
  19
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  187
• 氢给体数：
  3
• 氢受体数：
  14

反应信息

• 作为反应物：
  描述：

  Bn(-3)Ido2Ac(a1-4)[CbzNH(-2d)][Bn(-3)]a-Glc1Me6Ac 在 palladium on activated charcoal 2,2,6,6-tetramethyl-piperidine-N-oxyl 、 sodium hydroxide 、 sodium hypochlorite 、 sodium chlorite 、 sodium dihydrogenphosphate 、 pyridine-SO3 complex 、 氢气 、 sodium methylate 、 potassium bromide 、 silver(l) oxide 作用下， 以 甲醇 、 水 、 N,N-二甲基甲酰胺 、 乙腈 、 叔丁醇 为溶剂， 生成
  参考文献：
  名称：

  Synthesis of heparin partial structures and their binding activities to platelets

  摘要：

  A synthetic pentasaccharide corresponding to the antithrombin III-binding region in heparin was also found to bind to human platelets. To identify the platelet-binding site in the pentasaccharide which is expected to be a novel sequence in heparin responsible for its platelet-binding, five partial structures of this particular pentasaccharide were synthesized. In a competitive assay using [H-3]-heparin, a trisaccharide, O-(2-deoxy-2-sulfamido-3,6-di-O-sulfo-alpha-D-glucopyranosyl)-(1-->4)-O-(2-O-sulfo-alpha-L-idopyranosyluronic acid)-(1-->4)-2-deoxy-2-sulfamido-6-O-sulfo-alpha-D-glucopyranose, was concluded to be a high-affinity site for heparin's binding to platelets. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00550-8
• 作为产物：
  描述：

  [(2S,3R,4R,5S,6R)-4-Benzyloxy-5-((4aS,6S,7R,8R,8aR)-8-benzyloxy-7-hydroxy-2,2-dimethyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-6-hydroxymethyl-2-methoxy-tetrahydro-pyran-3-yl]-carbamic acid benzyl ester 在 吡啶 、 4-二甲氨基吡啶 、 溶剂黄146 作用下， 以 二氯甲烷 为溶剂， 生成 Bn(-3)Ido2Ac(a1-4)[CbzNH(-2d)][Bn(-3)]a-Glc1Me6Ac
  参考文献：
  名称：

  Synthesis of heparin partial structures and their binding activities to platelets

  摘要：

  A synthetic pentasaccharide corresponding to the antithrombin III-binding region in heparin was also found to bind to human platelets. To identify the platelet-binding site in the pentasaccharide which is expected to be a novel sequence in heparin responsible for its platelet-binding, five partial structures of this particular pentasaccharide were synthesized. In a competitive assay using [H-3]-heparin, a trisaccharide, O-(2-deoxy-2-sulfamido-3,6-di-O-sulfo-alpha-D-glucopyranosyl)-(1-->4)-O-(2-O-sulfo-alpha-L-idopyranosyluronic acid)-(1-->4)-2-deoxy-2-sulfamido-6-O-sulfo-alpha-D-glucopyranose, was concluded to be a high-affinity site for heparin's binding to platelets. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00550-8

文献信息

• Process for selective oxidation of primary alcohols of oligosaccharides
  申请人：Akzo Nobel N.V.

  公开号：EP0979826B1

  公开（公告）日：2002-11-06
• US6310200B1
  申请人：——

  公开号：US6310200B1

  公开（公告）日：2001-10-30