1-(2-benzylselenenyl-5-methoxy-3,4,6-trimethylphenyl)-3,7,11,15-tetramethyl-3-hexadecanol | 876389-23-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 1-(2-benzylselenenyl-5-methoxy-3,4,6-trimethylphenyl)-3,7,11,15-tetramethyl-3-hexadecanol
• 英文别名: 1-(2-Benzylselanyl-5-methoxy-3,4,6-trimethylphenyl)-3,7,11,15-tetramethylhexadecan-3-ol
• CAS: 876389-23-0
• 化学式: C₃₇H₆₀O₂Se
• 分子量: 615.842
• InChiKey: TUNHZTDIRTWMNO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.27
• 重原子数：
  40
• 可旋转键数：
  19
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(2-benzylselenenyl-5-methoxy-3,4,6-trimethylphenyl)-3,7,11,15-tetramethyl-3-hexadecanol 在 草酰氯 、 4-二甲氨基吡啶 、 2-mercaptopyridine-1-oxide sodium salt 作用下， 以 甲苯 为溶剂， 反应 15.0h， 以49%的产率得到6-methoxy-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)selenochromane
  参考文献：
  名称：

  Synthesis and Antioxidant Profile of all-rac-α-Selenotocopherol

  摘要：

  all-rac-alpha-Selenotocopherol (6c) has been synthesized in 11 steps in 6.6% total yield. Key steps include chloromethylation to approach the persubstituted aromatic 9b and cyclization of alcohol precursor 10 by radical homolytic substitution at selenium to form the selenotocopherol heterocycle. Determination of the OH bond dissociation enthalpy (BDE) of 6c by electron paramagnetic resonance (EPR) equilibration techniques gave a value of 78.1 +/- 0.3 kcal mol(-1), approximately I kcal mol(-1) higher than that of a-tocopherol. Kinetic studies performed by measuring oxygen uptake of the induced oxidation of styrene in the presence of an antioxidant showed that selenotocopherol (6c) was a slightly poorer inhibitor than (x-tocopherol, in agreement with the BDE values. In contrast to simpler setenotocopherol analogues, 6c was not regenerable in the presence of a stoichiometric coreductant in a two-phase lipid peroxidation model.

  DOI：

  10.1021/jo052133e
• 作为产物：
  描述：

  2-bromo-5-methoxy-3,4,6-trimethylbenzyl chloride 在 盐酸 、 叔丁基锂 、 sodium hydride 、 对甲苯磺酸 、 magnesium 作用下， 以 四氢呋喃 、 水 、 苯 为溶剂， 反应 66.83h， 生成 1-(2-benzylselenenyl-5-methoxy-3,4,6-trimethylphenyl)-3,7,11,15-tetramethyl-3-hexadecanol
  参考文献：
  名称：

  Synthesis and Antioxidant Profile of all-rac-α-Selenotocopherol

  摘要：

  all-rac-alpha-Selenotocopherol (6c) has been synthesized in 11 steps in 6.6% total yield. Key steps include chloromethylation to approach the persubstituted aromatic 9b and cyclization of alcohol precursor 10 by radical homolytic substitution at selenium to form the selenotocopherol heterocycle. Determination of the OH bond dissociation enthalpy (BDE) of 6c by electron paramagnetic resonance (EPR) equilibration techniques gave a value of 78.1 +/- 0.3 kcal mol(-1), approximately I kcal mol(-1) higher than that of a-tocopherol. Kinetic studies performed by measuring oxygen uptake of the induced oxidation of styrene in the presence of an antioxidant showed that selenotocopherol (6c) was a slightly poorer inhibitor than (x-tocopherol, in agreement with the BDE values. In contrast to simpler setenotocopherol analogues, 6c was not regenerable in the presence of a stoichiometric coreductant in a two-phase lipid peroxidation model.

  DOI：

  10.1021/jo052133e

文献信息

• Synthesis and Antioxidant Profile of all-<i>r</i><i>ac</i>-α-Selenotocopherol
  作者：David Shanks、Riccardo Amorati、Maria Grazia Fumo、Gian Franco Pedulli、Luca Valgimigli、Lars Engman

  DOI：10.1021/jo052133e

  日期：2006.2.1

  all-rac-alpha-Selenotocopherol (6c) has been synthesized in 11 steps in 6.6% total yield. Key steps include chloromethylation to approach the persubstituted aromatic 9b and cyclization of alcohol precursor 10 by radical homolytic substitution at selenium to form the selenotocopherol heterocycle. Determination of the OH bond dissociation enthalpy (BDE) of 6c by electron paramagnetic resonance (EPR) equilibration techniques gave a value of 78.1 +/- 0.3 kcal mol(-1), approximately I kcal mol(-1) higher than that of a-tocopherol. Kinetic studies performed by measuring oxygen uptake of the induced oxidation of styrene in the presence of an antioxidant showed that selenotocopherol (6c) was a slightly poorer inhibitor than (x-tocopherol, in agreement with the BDE values. In contrast to simpler setenotocopherol analogues, 6c was not regenerable in the presence of a stoichiometric coreductant in a two-phase lipid peroxidation model.