4-氯-5-氟-1-(p-甲苯磺酰)吡咯并[2,3-b]吡啶 | 50376-38-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异黄酮类化合物
• 中文名称: 4-氯-5-氟-1-(p-甲苯磺酰)吡咯并[2,3-b]吡啶
• 英文名称: millettone
• 英文别名: (1S,14S)-7,7-dimethyl-2,8,18,20,24-pentaoxahexacyclo[12.11.0.03,12.04,9.015,23.017,21]pentacosa-3(12),4(9),5,10,15,17(21),22-heptaen-13-one
• CAS: 50376-38-0
• 化学式: C₂₂H₁₈O₆
• 分子量: 378.381
• InChiKey: TXNSUHKZCOMFPN-MOPGFXCFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  28
• 可旋转键数：
  0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  63.2
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  12-dihydromillettosin 在 盐酸 作用下， 以 甲醇 为溶剂， 反应 48.0h， 以39 mg的产率得到4-氯-5-氟-1-(p-甲苯磺酰)吡咯并[2,3-b]吡啶
  参考文献：
  名称：

  来自 Millettia usaramensis 亚种 usaramensis 茎皮的类胡萝卜素、异黄酮和查耳酮

  摘要：

  来自 Millettia usaramensis subsp. 的茎皮。usaramensis 四种具有不寻常反式 B/C 环连接的新 12a-羟基胡萝卜素（(+)-12a-epimillettosin、(+)-usararotenoid-A、(+)-12-dihydrousararotenoid-A 和 (+)-usararotenoid-B )，已分离出一种新的 α-羟基二氢查尔酮 (α,4,2'-trihydroxy-4'-O-geranyldihydrochalcone)、一种新的异黄酮 (norisojamicin) 和一种新的肉桂醇衍生物 (4-O-geranylcinnamyl acetate)和特点。此外，还鉴定了已知化合物 4'-O-香叶基异甘草素、异甘草素、巴比灵酮、牙买素和最大异黄酮-G。结构是在光谱证据和化学转化的基础上确定的。

  DOI：

  10.1016/s0031-9422(97)00424-x

文献信息

• Chemical entities that kill senescent cells for use in treating age-related disease
  申请人：Unity Biotechnology, Inc.

  公开号：US10195213B2

  公开（公告）日：2019-02-05

  Disclosed herein are compounds that are effective for treatment of various disease states associated with senescence. The disclosed compounds can be used to eliminate senescent cells for disease treatment. The dosing of the compounds includes both single administration and regimens of cycling dosages.

  本文公开的化合物可有效治疗与衰老有关的各种疾病状态。所公开的化合物可用于消除衰老细胞以治疗疾病。化合物的给药方式包括单次给药和循环给药。
• COMPOSITIONS AND METHODS TO ADD VALUE TO PLANT PRODUCTS, SO INCREASING THE COMMERCIAL QUALITY, RESISTANCE TO EXTERNAL FACTORS AND POLYPHENOL CONTENT THEREOF
  申请人：Leschot Sanhueza, Andres Antonio

  公开号：EP2003968A2

  公开（公告）日：2008-12-24
• Compositions and methods to add value to plant products, increasing the commercial quality, resistance to external factors and polyphenol content thereof
  申请人：Nappa Olivera Alvaro

  公开号：US20070232495A1

  公开（公告）日：2007-10-04

  The invention is related to compositions and methods that naturally protect plant tissues against ultraviolet radiation and temperature, thus giving protection against sunburn to plants, plant parts, fruits and/or flowers during their development. The invention is also related to compositions and methods to naturally improve the color of plants, plant parts, fruits and/or flowers by inducing the natural synthesis of flavonoids and anthocyanins present in plants. Likewise, the present invention is directed to improving the nutritional value of plants, plant parts, fruits and/or flowers by increasing the normal levels of polyphenolic compounds, especially flavonoids, present therein. Additionally, the present invention is related to compositions and methods that give more resistance to plants, plant parts, fruits and/or flowers against pathogens as bacteria and fungi. Finally, the present invention is related to plants, plant parts, fruits, flowers and/or propagating material treated with the compositions described in the present document.
• COMPOUNDS AND THERAPEUTIC USES
  申请人：Unity Biotechnology, Inc.

  公开号：US20170281649A1

  公开（公告）日：2017-10-05

  Disclosed herein are compounds that are effective for treatment of various disease states associated with senescence. The disclosed compounds can be used to eliminate senescent cells for disease treatment. The dosing of the compounds includes both single administration and regimens of cycling dosages.
• US6492389B1
  申请人：——

  公开号：US6492389B1

  公开（公告）日：2002-12-10