顺丁烯二酸氢铵 | 44742-89-4

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 顺丁烯二酸氢铵
• 中文别名: 马来酸单铵；顺丁烯二酸一铵；马来酸氢铵；马来酸铵
• 英文名称: maleic acid fully monoammonium salt
• 英文别名: ammonium hydrogen maleate；maleic acid ammonium salt；maleic acid ; acidic ammonium salt；Maleinsaeure; Saures Ammoniumsalz；Einecs 256-163-5；azane;(Z)-but-2-enedioic acid
• CAS: 44742-89-4
• 化学式: C₄H₄O₄*H₃N
• 分子量: 133.104
• InChiKey: NLVWBYNKMPGKRG-ODZAUARKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.25
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  78.4
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 海关编码：
  2923900090

反应信息

• 作为反应物：
  描述：

  顺丁烯二酸氢铵 在 KGHNMGIHRIGLVVPSSNVTVETEMPALLNRHADARFSFHSSRMRMQSVSPEQLRAMNAQRERCILELGDAGVDAILYACLVALMSVGPGEHQRVEGLIAEQLATGGSEAAIRSSAGALVEALHAIHAERIVLVTPYMRPLAEQVVAYIEAEGIRVTDWRALEVADNAEYGCIPGHRVMDAARSLDRAGADALVLSACVQMPSLDLVQSAEDEFGLPVLSAATAGAYSLLRALDLAVDIPGAGGLLRADAPATTVQ 作用下， 以 aq. phosphate buffer 为溶剂， 反应 0.17h， 生成 富马酸
  参考文献：
  名称：

  N-terminal truncation of a maleate cis–trans isomerase from Rhodococcus jostii RHA1 results in a highly active enzyme for the biocatalytic production of fumaric acid

  摘要：

  As part of the project to develop an efficient biocatalytic process for the production of fumaric acid, a full-length putative maleate cis-trans isomerase gene from Rhodococcus jostii RHA1 was synthesized and expressed in Escherichia coli Rosetta2 (DE3) pLysS, but the protein was not soluble and showed no catalytic activity. Bioinformatics analysis of the protein sequence indicated that there were two hydrophilic and two hydrophobic amino acid clusters in an alternate arrangement at the N-terminus, and 50 extra amino acid residues at the N-terminus were not present in the known maleate cis-trans isomerases. The alternate hydrophilic and hydrophobic clusters at the N-terminus were thus truncated one by one to evaluate their effect on the gene expression and enzyme activity. Three mutants (MaiR-D41/42-304AA, MaiR-D48/49-304AA and MaiR-D52/53-304AA) without the hydrophilic and hydrophobic clusters were expressed as soluble protein with maleate cis-trans isomerase activity. Among them, MaiR-D48 was purified and its properties were studied. The purified enzyme had a temperature optimum of 40 degrees C and a wide pH range (5.0-9.0) with the optimum pH being 8.0: The whole cells of E. coli expressing MaiR-D48 catalyzed the isomerization of maleic acid to fumaric acid at I M substrate concentration, showing its potential for industrial use. (C) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molcatb.2013.04.002
• 作为产物：
  描述：

  顺丁烯二酸 在 氨 作用下， 生成 顺丁烯二酸氢铵
  参考文献：
  名称：

  Production of ammonia salts of maleic acid

  摘要：

  公开号：

  US02474089A1

文献信息

• METHOD FOR PREPARING IMINODISUCCINATE CHELATING AGENT
  申请人：HEBEI THINK-DO ENVIRONMENT CO., LTD.

  公开号：US20170121277A1

  公开（公告）日：2017-05-04

  A method for preparing an iminodisuccinate chelating agent, wherein a reaction comprising raw material A, raw material B, an alkali metal hydroxide, and water is carried out under ambient pressure, and at a pH in the range of 6-12 and a reaction temperature ranging from 65° C. to a boiling reflux temperature, and the mixed liquid obtained after the reaction is a mixture containing the iminodisuccinate chelating agent. The raw material A is a compound capable of obtaining a maleate through alkaline hydrolysis; and the raw material B is a compound capable of obtaining an aspartic acid through alkaline hydrolysis. With mild reaction conditions, a short reaction time and a high reaction yield, the preparation method is able to shorten the production process, improve the production efficiency, and reduce the production cost, and it is truly a preparation method which is highly efficient, environmentally friendly, and extremely suitable for industrial scale production.

  一种制备亚胺二琥珀酸螯合剂的方法，其中在常压下进行包括原料A、原料B、碱金属氢氧化物和水的反应，在pH值为6-12范围内和反应温度在65°C至沸点回流温度范围内进行，反应后得到的混合液体是含有亚胺二琥珀酸螯合剂的混合物。原料A是一种能够通过碱性水解得到马来酸盐的化合物；原料B是一种能够通过碱性水解得到天冬氨酸的化合物。在温和的反应条件下，短的反应时间和高的反应产率，该制备方法能够缩短生产过程，提高生产效率，降低生产成本，是一种高效、环保且非常适合工业规模生产的制备方法。
• Aspartic acid copolymers and their preparation
  申请人：Donlar Corporation

  公开号：US05478919A1

  公开（公告）日：1995-12-26

  Aspartic acid precursors such as mono and diammonium maleate, maleamic acid, ammonium maleamate, ammonium malate and mixtures of these and other precursors are copolycondensed thermally with a variety of mono, di and multifunctional monomers containing amino, hydroxyl and carboxyl functional groups. The resulting condensation copolymers and terpolymers contain succinimide units derived from aspartic acid precursors, condensed with other functional group monomers usually though amide and ester linkages. Hydrolysis of the polysuccinimide copolymers and terpolymers with alkali, alkaline earth and ammonium hydroxide produces aspartic acid copolymer and terpolymer salts.

  天冬氨酸的前体物，例如单酸和二羧酸盐、马来酰胺酸、铵马来酸酰胺、铵苹果酸盐以及这些和其他前体物的混合物，与一系列含有氨基、羟基和羧基官能团的单体进行热共聚缩合。所得的缩合共聚物和三元共聚物含有从天冬氨酸前体物中衍生的琥珀酰亚胺单元，通常通过酰胺和酯键与其他官能团单体缩合。用碱、碱土和铵氢氧化物水解多琥珀酰亚胺共聚物和三元共聚物，产生天冬氨酸共聚物和三元共聚物盐。
• Preparation of salt of polyaspartic acid by high temperature reaction
  申请人：Srchem Incorporated

  公开号：US05288783A1

  公开（公告）日：1994-02-22

  Polyaspartate, useful or inhibition of incrustations due to materials causing hardness in water and of value in detergent formulations, can be prepared by reacting maleic acid or fumaric acid in a molar ratio of 1:1-2.1 at temperatures greater than 170.degree. C., followed by conversion of the polymer formed in this reaction to a salt of polyaspartic acid by basic hydrolysis.

  聚天冬氨酸（Polyaspartate）是一种有用的物质，可以抑制水中硬度物质引起的结垢，并在清洁剂配方中具有价值。它可以通过在大于170°C的温度下以1:1-2.1的摩尔比反应丙烯酸或反式丁烯二酸，然后通过碱性水解将反应形成的聚合物转化为聚天冬氨酸盐来制备。
• Method for producing L-aspartic acid
  申请人：Mitsubishi Chemical Corporation

  公开号：US05741681A1

  公开（公告）日：1998-04-21

  L-aspartic acid is produced by repeating the following respective steps: (1) a reaction step of producing ammonium L-aspartate from an aqueous solution containing monoammonium maleate in accordance with an isomerization reaction and an enzyme reaction caused by aspartase in the presence of ammonia; (2) an ammonia-eliminating step of converting substantially all produced ammonium L-aspartate into monoammonium salt by distilling or stripping a reaction solution obtained in the step (1); (3) a crystallization step of crystallizing L-aspartic acid and producing monoammonium maleate from a solution obtained in the step (2) by adding maleic acid, maleic anhydride or both; (4) a solid-liquid separation step of separating L-aspartic acid crystals precipitated in the step (3) from a mother liquor containing monoammonium maleate; and (5) a recycle step of supplying the mother liquor containing monoammonium maleate obtained in the step (4) to the step (1) to be used as a raw material for the reaction.

  L-天冬氨酸的生产过程包括以下步骤：(1) 在氨的存在下，通过天冬酰胺酶的异构化反应和酶反应，从含有单羟基丙烯酸铵的水溶液中产生铵盐型L-天冬氨酸；(2) 通过蒸馏或挥发反应溶液中的大部分铵盐型L-天冬氨酸，将其转化为单羟基丙烯酸铵盐；(3) 通过加入马来酸、马来酸酐或两者的溶液，结晶L-天冬氨酸并产生单羟基丙烯酸铵盐；(4) 将步骤(3)中沉淀的L-天冬氨酸晶体从含有单羟基丙烯酸铵盐的母液中分离出来；(5) 将步骤(4)中获得的含有单羟基丙烯酸铵盐的母液回收并用作步骤(1)的原料。
• Preparation of polyaspartic acid by high temperature reaction
  申请人：Srchem Incorporated

  公开号：US05367047A1

  公开（公告）日：1994-11-22

  Polyaspartate, useful for inhibition of incrustations due to materials causing hardness in water and of value in detergent formulations, can be prepared by reacting maleic acid or fumaric acid in a molar ratio of 1:1-2.1 at temperatures greater than 190.degree. C., followed by conversion of the polymer formed in this reaction to a salt of polyaspartic acid by basic hydrolysis.

  聚天冬氨酸是一种有用的化合物，可用于抑制因水中硬度物质而引起的结垢，并在洗涤剂配方中具有价值。它可以通过在摩尔比为1:1-2.1的条件下，将马来酸或富马酸在大于190摄氏度的温度下反应，然后通过碱性水解将在该反应中形成的聚合物转化为聚天冬氨酸盐来制备。