4-甲基-7-喹啉胺 | 114058-79-6

• 物质功能分类: 医药中间体 - 吡啶类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 4-甲基-7-喹啉胺
• 中文别名: 4-甲基-7-氨基喹啉
• 英文名称: 7-amino-4-methylquinoline
• 英文别名: 4-Methylquinolin-7-amine
• CAS: 114058-79-6
• 化学式: C₁₀H₁₀N₂
• mdl: MFCD11101020
• 分子量: 158.203
• InChiKey: MEWHVQCJPFDWIO-UHFFFAOYSA-N

物化性质

• 熔点：
  79-81 °C(Solv: hexane (110-54-3))
• 沸点：
  340.9±22.0 °C(Predicted)
• 密度：
  1.169±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  38.9
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2933499090

反应信息

• 作为产物：
  描述：

  间苯二胺 在 palladium on activated charcoal 氢气 、 三氯氧磷 作用下， 以 溶剂黄146 为溶剂， 反应 1.0h， 生成 4-甲基-7-喹啉胺
  参考文献：
  名称：

  7-Aminoquinolines. A novel class of agents active against herpes viruses

  摘要：

  A series of 7-aminoquinoline derivatives was synthesized and evaluated for their capacity to produce cytotoxicity in KB cells and to inhibit the replication of herpes simplex virus (HSV) type 1. All compounds tested inhibited the replication of HSV-1 with 50% inhibitory concentrations in the range of 2-50 micrograms/mL. The antiviral activity of many compounds, however, was separated from cytotoxicity to replicating uninfected cells by only two- to fivefold higher than those required for antiviral activity. Nonetheless, six compounds (10, 28, 29, 32, 34, and 36) were identified in which the separation was greater than fivefold. All compounds examined were more potent inhibitors of viral DNA synthesis than the cellular DNA synthesis.

  DOI：

  10.1021/jm00402a016

文献信息

• BICYCLICALLY SUBSTITUTED URACILS AND THE USE THEREOF
  申请人：BAYER PHARMA AKTIENGESELLSCHAFT

  公开号：US20150148340A1

  公开（公告）日：2015-05-28

  The present application relates to novel bicyclically substituted uracil derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases.

  本申请涉及新颖的双环替代尿嘧啶衍生物，其制备方法，单独或组合使用以治疗和/或预防疾病，以及用于生产治疗和/或预防疾病药物的用途。
• Novel chromophore containing compounds
  申请人：MERCK & CO. INC.

  公开号：EP0528487A2

  公开（公告）日：1993-02-24

  Disclosed are novel chromophore containing compounds of Formula I and their use in determining interleukin-1β convertase (ICE) activity. ICE has been implicated in inflammatory or immune-based diseases of the lung and airways; central nervous system and surrounding membranes; the eyes and ears; joints, bones, and connective tissues; cardiovascular system including the pericardium; the gastrointestinal and urogenital systems; the skin and mucosal membranes.

  本发明公开了含有式 I 的新型发色团化合物及其在测定白细胞介素-1β 转化酶（ICE）活性中的用途。白细胞介素-1β转换酶与以下部位的炎症性或免疫性疾病有关：肺和呼吸道；中枢神经系统和周围的膜；眼睛和耳朵；关节、骨骼和结缔组织；心血管系统，包括心包；胃肠道和泌尿生殖系统；皮肤和粘膜。
• Bicyclically substituted uracils and the use thereof
  申请人：Bayer Pharma Aktiengesellschaft

  公开号：US10300062B2

  公开（公告）日：2019-05-28

  The present application relates to novel bicyclically substituted uracil derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases.

  本申请涉及新型双环取代的尿嘧啶衍生物、其制备工艺、其单独使用或组合使用以治疗和/或预防疾病，以及其用于生产治疗和/或预防疾病的药物。
• NASR, M.;DRACH, J. C.;SMITH, S. H.;SHIPMAN, CH. , (JR);BURCKHALTER, J. H., J. MED. CHEM., 31,(1988) N 7, C. 1347-1351
  作者：NASR, M.、DRACH, J. C.、SMITH, S. H.、SHIPMAN, CH. , (JR)、BURCKHALTER, J. H.

  DOI：——

  日期：——
• METAL TRIANGULO COMPOUND AND METHODS OF USING THE SAME
  申请人：National University of Singapore

  公开号：EP2147005A1

  公开（公告）日：2010-01-27