7β-hydroxydehydroabietic acid | 73609-55-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 7β-hydroxydehydroabietic acid
• 英文别名: 7beta-Hydroxydehydroabietic acid；(1R,4aS,9S,10aR)-9-hydroxy-1,4a-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthrene-1-carboxylic acid
• CAS: 73609-55-9
• 化学式: C₂₀H₂₈O₃
• 分子量: 316.441
• InChiKey: GPFVBJYXFRIOFB-ONCXSQPRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  脱氢松香酸 在 叔丁基过氧化氢 、 sodium tetrahydroborate 、 重铬酸吡啶 、 Celite 作用下， 以 异丙醇 、 苯 为溶剂， 反应 3.25h， 生成 7β-hydroxydehydroabietic acid
  参考文献：
  名称：

  Krohn, Karsten; Budianto, Emil; Floerke, Ulrich, Liebigs Annalen der Chemie, 1992, # 9, p. 911 - 920

  摘要：

  DOI：

文献信息

• Biotransformation of abietic acid by fungi and biological evaluation of its metabolites
  作者：Özge Özşen、İsmail Kıran、İlknur Dağ、Özlem Atlı、Gülşen A. Çiftçi、Fatih Demirci

  DOI：10.1016/j.procbio.2016.09.022

  日期：2017.1

  Abstract Biotransformation of abietic acid was carried out initially using 28 different microbial strains. Among the evaluated, Mucor ramannianus produced a known metabolite 2 α -hydroxy-dehydroabietic acid whereas Neurospora crassa yielded two known metabolites of 7 β -hydroxy-dehydroabietic and 1 β -hydroxy-dehydroabietic acids in 12.7, 15.5 and 20.1% yields, respectively. The in vitro antimicrobial

  摘要 松香酸的生物转化最初使用 28 种不同的微生物菌株进行。在评估中，毛霉菌产生了一种已知的代谢物 2α-羟基-脱氢松香酸，而粗糙脉孢菌产生了两种已知的 7β-羟基-脱氢松香酸和 1β-羟基-脱氢松香酸的代谢物，产率分别为 12.7、15.5 和 20.1%。代谢物的体外抗微生物活性针对 19 种不同的病原微生物进行了评估，与标准相比，具有中等抑制活性，MIC > 250 μg/mL。然而，在体外抗癌活性研究中，发现 2 α-羟基-脱氢松香酸是对 A549 人肺腺癌细胞系最有效的衍生物，IC 50 值为 320.8 μg/mL，SI（选择性指数）为 156 , 分别。使用相同的测定和条件，发现 7 β-羟基-脱氢松香是最有效和选择性的抗 HepG2 细胞系增殖剂，其 IC 50 值分别为 196.6 μg/mL 和 SI 为 187。与抗菌活性相反，生物转化代谢物显示出有希望的结果，表明
• The extraction of structure during reading: Evidence from reading prosody
  作者：Asher Koriat、Hamutal Kreiner、Seth N. Greenberg

  DOI：10.3758/bf03195288

  日期：2002.3

  According to the structural approach to reading, the extraction of structure precedes the analysis of meaning and paves the way for it. In this study, reading prosody was used to examine this proposition. Specifically, we tested the hypothesis that reading prosody produced on line reflects the early extraction of structure. In Experiment 1, readers were successful in assigning natural prosody to unfamiliar text immediately upon its reading. Experiment 2 showed that the prosodic patterns applied are tuned to the structure of the sentence and are largely indifferent to the content of the sentence or to its semantic coherence. The results join with other findings in speech production and comprehension in supporting the precedence of structure to meaning in reading.
• Microbial transformations of diterpene acids
  作者：Aleksei V. Vorob’ev、Victoria V. Grishko、Irina B. Ivshina、Emma N. Shmidt、Leonid M. Pokrovskii、Maria S. Kuyukina、Genrikh A. Tolstikov

  DOI：10.1070/mc2001v011n02abeh001414

  日期：2001.1
• The Oxidation of Methyl Dehydroabietate by Molecular Oxygen
  作者：Paul F. Ritchie、Thomas F. Sanderson、Lane F. McBurney

  DOI：10.1021/ja01107a016

  日期：1953.6
• US7385083B2
  申请人：——

  公开号：US7385083B2

  公开（公告）日：2008-06-10