4,4,5-Trimethylthieno[3,2-c]quinolin-7-ol | 397882-65-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4,4,5-Trimethylthieno[3,2-c]quinolin-7-ol
• CAS: 397882-65-4
• 化学式: C₁₄H₁₅NOS
• 分子量: 245.345
• InChiKey: CLFHTXGFRJXBIV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  51.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  四氯苯二甲酸酐 、 4,4,5-Trimethylthieno[3,2-c]quinolin-7-ol 在 对甲苯磺酸 作用下， 以 丙酸 为溶剂， 以26%的产率得到
  参考文献：
  名称：

  合理设计和合成一类新型的高荧光若丹明染料，该染料在长波长下具有很强的吸收能力

  摘要：

  通过扩展发色团的π共轭能力有限的柔性，设计并合成了一类新型的强荧光若丹明染料。这些染料显示在581至631 nm范围内具有更长的吸收，量子产率在0.64至0.89之间。

  DOI：

  10.1016/s0040-4039(03)00938-9
• 作为产物：
  描述：

  4-溴-3-硝基苯甲醚 在 吡啶 、 盐酸 、 palladium diacetate 、 四丁基溴化铵 、 三溴化硼 、 potassium carbonate 、 锌 、 三氯氧磷 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 水 、 氯苯 为溶剂， 反应 50.5h， 生成 4,4,5-Trimethylthieno[3,2-c]quinolin-7-ol
  参考文献：
  名称：

  合理设计和合成一类新型的高荧光若丹明染料，该染料在长波长下具有很强的吸收能力

  摘要：

  通过扩展发色团的π共轭能力有限的柔性，设计并合成了一类新型的强荧光若丹明染料。这些染料显示在581至631 nm范围内具有更长的吸收，量子产率在0.64至0.89之间。

  DOI：

  10.1016/s0040-4039(03)00938-9

文献信息

• Derivatives of 1,2-dihydro-7-hydroxyquinolines containing fused rings
  申请人：Molecular Probes, Inc.

  公开号：US20040147747A1

  公开（公告）日：2004-07-29

  The present invention describes novel dyes, including coumarins, rhodamines, and rhodols that incorporate additional fused aromatic rings. The dyes of the invention absorb at a longer wavelength than structurally similar dyes that do not possess the fused aromatic rings. Many of the dyes of the invention are useful fluorescent dyes. The invention includes chemically reactive dyes, dye-conjugates, and the use of such dyes in staining samples and detecting ligands or other analytes.

  本发明描述了新型染料，包括香豆素、罗丹明和罗多尔，这些染料融合了额外的稠合芳香环。本发明的染料吸收波长比结构相似但不具有稠合芳香环的染料更长。本发明的许多染料是有用的荧光染料。本发明包括化学活性染料、染料偶联物，以及这些染料在染色样品和检测配体或其他分析物中的应用。
• DERIVATIVES OF 1,2-DIHYDRO-7-HYDROXYQUINOLINES CONTAINING FUSED RINGS
  申请人：Diwu Zhenjun

  公开号：US20070093652A1

  公开（公告）日：2007-04-26

  The present invention describes novel dyes, including coumarins, rhodamines, and rhodols that incorporate additional fused aromatic rings. The dyes of the invention absorb at a longer wavelength than structurally similar dyes that do not possess the fused aromatic rings. Many of the dyes of the invention are useful fluorescent dyes. The invention includes chemically reactive dyes, dye-conjugates, and the use of such dyes in staining samples and detecting ligands or other analytes.
• Water-Soluble, Fluorescent Compounds for Detection of Potassium Ions
  申请人：Verkman Alan

  公开号：US20080311041A1

  公开（公告）日：2008-12-18

  The invention provides chromoionophore compounds comprising a triazacryptand (TAC) K + ionophore conjugated to at least a first chromophoric moiety (e.g., xanthylium dyes and derivatives thereof). In related embodiments, the chromoionophore compounds further comprise a second chromophoric moiety which is insensitive to potassium binding by the TAC ionophore, thus providing for dual wavelength detection and absolute determination of K + concentration. The invention further provides methods and kits for the determination of K + concentrations in biological systems, either in vitro or in vivo, using embodiments of inventive chromoionophores.
• Derivatives of 1,2-dihydro-7-hydroxyquinolines Containing Fused Rings
  申请人：DIWU Zhenjun

  公开号：US20110027800A1

  公开（公告）日：2011-02-03

  The present invention describes novel dyes, including coumarins, rhodamines, and rhodols that incorporate additional fused aromatic rings. The dyes of the invention absorb at a longer wavelength than structurally similar dyes that do not possess the fused aromatic rings. Many of the dyes of the invention are useful fluorescent dyes. The invention includes chemically reactive dyes, dye-conjugates, and the use of such dyes in staining samples and detecting ligands or other analytes.
• US7169922B2
  申请人：——

  公开号：US7169922B2

  公开（公告）日：2007-01-30