Regioselective synthesis of polysubstituted benzenes from Baylis–Hillman adducts via [4+2] annulation protocol
作者:Mi Jung Lee、Ka Young Lee、Da Yeon Park、Jae Nyoung Kim
DOI:10.1016/j.tet.2006.01.028
日期:2006.3
A new and regioselective [4+2] benzannulation protocol toward polysubstituted benzenes was developed. A nitroalkane derivative, which was prepared from Baylis–Hillman adduct, served as the four-carbon unit and a Michael acceptor as a two-carbon unit. Vinyltriphenylphosphonium salt could also be used as a Michael acceptor efficiently.
开发了一种针对多取代苯的新的区域选择性[4 + 2]苯环芳烃方案。由Baylis–Hillman加合物制备的硝基烷衍生物用作四碳单元,而Michael受体用作二碳单元。乙烯基三苯基phosph盐也可以有效地用作迈克尔受体。