4-硝基苯甲酰替苯胺 | 3460-11-5
中文名称
4-硝基苯甲酰替苯胺
中文别名
4-硝基-N-苯基苯甲酰胺
英文名称
4-nitrobenzanilide
英文别名
4-nitro-N-(phenyl)benzamide；N-phenyl-4-nitrobenzamide；p-nitro-N-phenylbenzamide；4-nitro-N-phenylbenzamide
CAS
3460-11-5
化学式
C13H10N2O3
mdl
MFCD00017034
分子量
242.234
InChiKey
KCBREZOWOLOPLW-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
- 物化性质
- 计算性质
- ADMET
- 安全信息
- SDS
- 制备方法与用途
- 上下游信息
- 文献信息
- 表征谱图
- 同类化合物
- 相关功能分类
- 相关结构分类
计算性质
- 辛醇/水分配系数(LogP)：2.4
- 重原子数：18
- 可旋转键数：2
- 环数：2.0
- sp3杂化的碳原子比例：0.0
- 拓扑面积：74.9
- 氢给体数：1
- 氢受体数：3
安全信息
- 海关编码：2924299090
SDS
Version 1.0
Regulation (EC) No 1907/2006
1 - Product and Company Information
Product Name 4-NITROBENZANILIDE - 50 MG
2 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Irritating to eyes.
3 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
4-NITROBENZANILIDE 3460-11-5 222-403-2 None
Formula C13H10N2O3
Molecular Weight 242,2400 AMU
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.
AFTER EYE CONTACT
In case of contact, immediately flush eyes with copious amounts
of water for at least 15 minutes.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
ALDRICH www.molbase.com
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear respirator, chemical safety goggles, rubber boots, and
heavy rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Avoid contact
with eyes, skin, and clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Use respirators and components tested and
approved under appropriate government standards such as NIOSH (US)
or CEN (EU). Where risk assessment shows air-purifying respirators
are appropriate use a dust mask type N95 (US) or type P1 (EN 143)
respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
MP/MP Range N/A
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
ALDRICH www.molbase.com
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
Partition Coefficient Log Kow: 2,188
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
SENSITIZATION
Sensitization: Possible sensitizer.
Skin: The preceding data, or interpretation of data, was
determined using Quantitative Structure Activity Relationship
(QSAR) modeling. Prolonged or repeated exposure may cause
allergic reactions in certain sensitive individuals.
SIGNS AND SYMPTOMS OF EXPOSURE
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes eye irritation.
Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract.
Ingestion: May be harmful if swallowed.
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
ALDRICH www.molbase.com
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: Xi
Irritant.
R-PHRASES: 36
Irritating to eyes.
S-PHRASES: 26
In case of contact with eyes, rinse immediately with plenty of
water and seek medical advice.
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2010 Co. License granted to make
unlimitedpaper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
ALDRICH www.molbase.com
SECTION 16 - ADDITIONAL INFORMATION
N/A
Regulation (EC) No 1907/2006
1 - Product and Company Information
Product Name 4-NITROBENZANILIDE - 50 MG
2 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Irritating to eyes.
3 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
4-NITROBENZANILIDE 3460-11-5 222-403-2 None
Formula C13H10N2O3
Molecular Weight 242,2400 AMU
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.
AFTER EYE CONTACT
In case of contact, immediately flush eyes with copious amounts
of water for at least 15 minutes.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
ALDRICH www.molbase.com
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear respirator, chemical safety goggles, rubber boots, and
heavy rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Avoid contact
with eyes, skin, and clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Use respirators and components tested and
approved under appropriate government standards such as NIOSH (US)
or CEN (EU). Where risk assessment shows air-purifying respirators
are appropriate use a dust mask type N95 (US) or type P1 (EN 143)
respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
MP/MP Range N/A
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
ALDRICH www.molbase.com
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
Partition Coefficient Log Kow: 2,188
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
SENSITIZATION
Sensitization: Possible sensitizer.
Skin: The preceding data, or interpretation of data, was
determined using Quantitative Structure Activity Relationship
(QSAR) modeling. Prolonged or repeated exposure may cause
allergic reactions in certain sensitive individuals.
SIGNS AND SYMPTOMS OF EXPOSURE
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes eye irritation.
Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract.
Ingestion: May be harmful if swallowed.
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
ALDRICH www.molbase.com
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: Xi
Irritant.
R-PHRASES: 36
Irritating to eyes.
S-PHRASES: 26
In case of contact with eyes, rinse immediately with plenty of
water and seek medical advice.
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2010 Co. License granted to make
unlimitedpaper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
ALDRICH www.molbase.com
SECTION 16 - ADDITIONAL INFORMATION
N/A
上下游信息
- 上游原料
中文名称 英文名称 CAS号 化学式 分子量 N-(2-氨基苯基)-4-硝基苯甲酰胺 2'-amino-4-nitrobenzanilide 6338-73-4 C13H11N3O3 257.249 4'-硝基苯甲酰苯胺 p-nitrobenzanilide 3393-96-2 C13H10N2O3 242.234 N-(2-碘苯基)-4-硝基苯甲酰胺 N-(2-iodophenyl)-4-nitrobenzamide 314285-30-8 C13H9IN2O3 368.131 N-(2-溴苯基)-4-硝基苯甲酰胺 N-(2-bromophenyl)-4-nitrobenzamide 99514-85-9 C13H9BrN2O3 321.13 N-甲基-4-硝基-N-苯基苯甲酰胺 N-methyl-N-phenyl-4-nitrobenzamide 961-61-5 C14H12N2O3 256.261 N-(2-氯苯基)-4-硝基苯甲酰胺 N-(2-chlorophenyl)-4-nitrobenzamide 2585-28-6 C13H9ClN2O3 276.679 N-羟基-4-硝基-N-苯基苯甲酰胺 N-hydroxy-N-phenyl-4-nitrobenzamide 2029-61-0 C13H10N2O4 258.233 对硝基苯甲酰胺 4-nitrobenzamide 619-80-7 C7H6N2O3 166.136 N-羟基-4-硝基苯甲酰胺 4-nitrobenzohydroxamic acid 1613-76-9 C7H6N2O4 182.136 4-硝基苯酰肼 4-Nitrobenzoic acid hydrazide 636-97-5 C7H7N3O3 181.151 - 1
- 2
- 下游产品
中文名称 英文名称 CAS号 化学式 分子量 —— 4-(4-nitro-benzoylamino)-benzoic acid anilide 70998-52-6 C20H15N3O4 361.357 N-(4-氯苯基)-4-硝基苯甲酰胺 4-nitro-N-(4-chlorophenyl)benzamide 2585-30-0 C13H9ClN2O3 276.679 N-(4-氟苯基)-4-硝基苯甲酰胺 N-(4-fluorophenyl)-4-nitrobenzamide 347-81-9 C13H9FN2O3 260.224 —— 4-N-phenylamidonitrosobenzene 135007-46-4 C13H10N2O2 226.235 —— 4-N-phenylamidohydroxylaminobenzene 135007-45-3 C13H12N2O2 228.25 N-甲基-4-硝基-N-苯基苯甲酰胺 N-methyl-N-phenyl-4-nitrobenzamide 961-61-5 C14H12N2O3 256.261 4-氨基苯甲酰苯胺 4-amino-benzoic acid anilide 782-45-6 C13H12N2O 212.251 —— 4-benzamido-N-phenylbenzamide 13755-08-3 C20H16N2O2 316.359 —— N-(4-nitrobenzyl)aniline 10359-18-9 C13H12N2O2 228.25 —— 4-Nitro-N,N-diphenylbenzamide 20971-31-7 C19H14N2O3 318.332 - 1
- 2
- 3
反应信息
- 作为反应物：描述：4-硝基苯甲酰替苯胺 在 劳森试剂 、 palladium 10% on activated carbon 、 氢气 、 sodium hydroxide 、 potassium hexacyanoferrate(III) 作用下， 以 二氯甲烷 、 水 、 氯苯 为溶剂， 生成 4-(2-苯并噻唑基)苯胺参考文献：名称：Design, synthesis and antimetastatic evaluation of 1-benzothiazolylphenylbenzotriazoles for photodynamic therapy in oral cancer cells摘要：我们设计并合成了一系列新的1-苯并噻唑基苯基三唑类化合物
9a–p 并研究了它们在口腔癌细胞Ca9-22中通过UVA诱导的光敏作用参与的抗转移机制。DOI：10.1039/c6md00034g - 作为产物：描述：参考文献：名称：作为诱导型一氧化氮合酶抑制剂的新型六氢哒嗪-1-羧酰亚胺，-碳硫代酰胺和-碳硫代亚甲基酸酯的合成，结构研究和生物学评估。摘要：局部过量的一氧化氮（NO）与β细胞损伤有关，因此，治疗自身免疫性IDDM的可能方法是选择性抑制诱导型一氧化氮合酶（iNOS）。合成了一系列各种取代的六氢哒嗪-1-碳硫酰胺，-碳硫代咪酸酯和-羧亚胺，并作为剂量依赖性地评估了iNOS的潜在抑制剂。用产生胰岛素的RIN-5AH细胞以及作为细胞NO产生诱导物的IL1-1β和IFN-γ的组合进行标题化合物的筛选。结构活性分析表明，六氢哒嗪位置1处取代基的变化强烈影响对iNOS的抑制活性，并且对于RIN细胞的存活至关重要。在测试的化合物中，六氢哒嗪-1-甲硫酰胺显示出特别显着的抑制作用。但是，对于有效的iNOS抑制作用，在1-碳硫酰胺基团的氮原子上进行取代非常重要。因此，分别引入脂族链（例如丙基或丁基）和环状部分（例如环己基，3-甲氧基苯基和4-甲氧基苯基）（IC（50）：0.5-2.1 mM），可提供与氨基胍具有相似抑制活性的化合物（IC（50）：0DOI：10.1016/j.bmc.2003.12.007
- 作为试剂：描述：苯甲酰胺 、 Tetramethylammonium hydroxide dihydrate 、 硝基苯 在 水 、 硝基苯 、 4-硝基苯甲酰替苯胺 、 4'-硝基苯甲酰苯胺 、 正己烷 作用下， 反应 24.0h， 以to obtain 43.5 g of 4-nitrobenzanilide (90% yield)的产率得到4-硝基苯甲酰替苯胺参考文献：名称：Process for preparing p-nitroaromatic amides and products thereof摘要：提供一种制备对硝基芳香酰胺的方法，包括在适当的溶剂体系中接触酰胺和硝基苯，并在适当的碱和受控量的质子性物质存在下，在受限制的反应区域中在适当的温度下反应酰胺和硝基苯。本发明的对硝基芳香酰胺可以还原为对氨基芳香酰胺。在一种实施方式中，对氨基芳香酰胺进一步与氨在条件下反应，产生相应的对氨基芳香胺和酰胺起始材料，可以回收或与水在适当的酸催化剂或碱催化剂存在下反应，产生相应的对氨基芳香胺和酰胺起始材料的酸或盐。在另一种实施方式中，对氨基芳香胺还原烷基化，产生烷基化的对氨基芳香胺。对硝基芳香酰胺可以在条件下与氨反应，产生相应的对硝基芳香胺和酰胺起始材料，可以回收或与水在适当的酸催化剂或碱催化剂存在下反应，产生相应的对硝基芳香胺和酰胺起始材料的酸或盐。在一种实施方式中，对硝基芳香胺还原产生对氨基芳香胺。在另一种实施方式中，对氨基芳香胺还原烷基化，产生烷基化的对氨基芳香胺。在另一种实施方式中，对硝基芳香胺还原烷基化，产生对氨基芳香胺。公开号：US05331099A1
文献信息
- An alternative and facile purification procedure of amidation and esterification reactions using a medium fluorous Mukaiyama reagent作者：Masato Matsugi、Misaki Suganuma、Shoko Yoshida、Shohei Hasebe、Yoko Kunda、Kotaro Hagihara、Sayaka OkaDOI：10.1016/j.tetlet.2008.09.016日期：2008.11convenient methodology for the separation of a fluorous by-product using fluorous chemistry is described. A Mukaiyama coupling reagent bearing a medium fluorous tag, between 40% and 60% fluorine by weight, can be effectively separated from non-fluorous components by increasing the water content of the crude reaction mixture and subsequent filtration. Additional fluorous solid phase extraction is not necessary描述了一种使用氟化学分离氟副产物的简便方法。通过增加粗反应混合物的水含量并随后过滤，可以有效地将氟含量在40％至60％之间的带有中等氟标签的Mukaiyama偶联剂与非氟组分有效地分离。不需要额外的氟固相萃取。
- Synthesis of S-thioacyl dithiophosphates, efficient and chemoselective thioacylating agentsProofs for the reversibility of isomerisation of anhydrides 1 to 2, melting points of amides and thioamides obtained from anhydrides 5–7 and 1H, 13C NMR and IR data of isolated anhydrides 5–7, 17 are available as supplementary data. For direct access, see http://www.rsc.org/suppdata/p1/b2/b201233b/作者：Leszek Doszczak、Janusz RachonDOI：10.1039/b201233b日期：2002.5.10Easily available acyl dithiophosphates are not stable and isomerise reversibly to O-thioacyl monothiophosphates, especially when subjected to heating. Much slower but probably irreversible isomerisation to S-thioacyl monothiophosphates occurs. Since equilibrium states are established and S-thioacyl (mono)thiophosphates form slowly, reaction mixtures contain generally both thioacylating and acylating agents, and consequently cannot be used for efficient thioacylation. On the other hand, treatment of a mixture of isomeric anhydrides with an excess of a dithiophosphoric acid leads to exclusive formation of S-thioacyl dithiophosphates. They appear to be excellent thioacylating agents: relatively stable, inert towards water and oxygen and therefore easy to handle. Reactions with nitrogen or sulfur nucleophiles proceed very rapidly under ambient conditions, yielding respective thioacyl derivatives. Isolation of the products is very simple. Due to the low reactivity of S-thioacyl dithiophosphates towards oxygen nucleophiles they can be used for direct thioacylation of multifunctional nucleophiles with unprotected hydroxy groups. Respective thioacyl derivatives cannot readily be obtained using other methods.容易获得的酰基二硫代磷酸酯不稳定，特别是在加热条件下，可以可逆地异构化为O-硫代酰基单硫代磷酸酯。转变为S-硫代酰基单硫代磷酸酯的过程要慢得多，但可能是不可逆的。由于建立了平衡状态，S-硫代酰基（单）硫代磷酸酯的形成较慢，反应混合物通常既含有硫代酰化剂也含有酰化剂，因此无法用于高效的硫代酰化反应。另一方面，将异构酸酐混合物与过量的二硫代磷酸反应，会导致仅形成S-硫代酰基二硫代磷酸酯。它们似乎是非常优秀的硫代酰化剂：相对稳定，对水和氧气不敏感，因此易于处理。它们在常温下与氮或硫亲核试剂的反应非常迅速，产生相应的硫代酰基衍生物。产品的分离非常简单。由于S-硫代酰基二硫代磷酸酯对氧亲核试剂的反应性较低，因此它们可以用于直接硫代酰化多功能亲核试剂，而不需要保护羟基。使用其他方法不易获得相应的硫代酰基衍生物。
- Platinum nanowires catalyzed direct amidation with aldehydes and amines作者：Dawei Xu、Linyan Shi、Danhua Ge、Xueqin Cao、Hongwei GuDOI：10.1007/s11426-015-5552-1日期：2016.4Different from the conventional synthesis methods and substrates, we designed a brand new method for synthesizing amides with platinum nanowires as catalysts and tert-butylhydroperoxide (TBHP) as the oxidant. Influence of factors, such as the catalyst, solvents, and the reaction temperature, were studied to determine the optimal reaction conditions. In addition, we explored the substrate generality与常规合成方法和底物不同，我们设计了一种全新的方法，以铂纳米线为催化剂，叔丁基过氧化氢（TBHP）为氧化剂合成酰胺。研究了催化剂，溶剂和反应温度等因素的影响，确定了最佳反应条件。此外，我们探索了基材的通用性并观察到了优异的产量。
- 一种铂纳米线催化合成酰胺类化合物的方法申请人：苏州大学公开号：CN104086345B公开（公告）日：2016-06-08本发明涉及一种铂纳米线催化合成酰胺类化合物的方法。具体而言，该方法包括如下步骤：向反应容器中加入分散于醇中的铂纳米线，减压除去醇，进一步加入三氯化铝、反应溶剂、吡啶、胺类化合物、醛类化合物和氧化剂，在搅拌的条件下，于油浴中加热反应，之后通过柱层析进行纯化，得到酰胺类化合物，其中：所述醛类化合物、胺类化合物、三氯化铝、吡啶、铂纳米线和氧化剂的摩尔比为0.5~3:0.5~3:0.1~0.5:0.5~2:0.1%~2%:0.5~5，所述加热反应的反应温度为80~140℃，反应时间为16~24小时。由于采用铂纳米线作为催化剂，本发明不仅催化活性高，而且性能稳定，同时本发明的方法能得到较高的产率，条件温和，工艺简单，易于操作。
- Unmasking Amides: Ruthenium-Catalyzed Protodecarbonylation of N-Substituted Phthalimide Derivatives作者：Yu-Chao Yuan、Raghu Kamaraj、Christian Bruneau、Thierry Labasque、Thierry Roisnel、Rafael Gramage-DoriaDOI：10.1021/acs.orglett.7b03278日期：2017.12.1The unprecedented transformation of a wide range of synthetically appealing phthalimides into amides in a single-step operation has been achieved in high yields and short reaction times using a ruthenium catalyst. Mechanistic studies revealed a unique, homogeneous pathway involving five-membered ring opening and CO2 release with water being the source of protons.使用钌催化剂，以高收率和较短的反应时间实现了单步操作中各种合成吸引力的邻苯二甲酰亚胺前所未有的转化为酰胺。机理研究表明，独特的均质途径涉及五元环的打开和CO 2的释放，其中水是质子的来源。
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