N-[[3,7-双(二甲基氨基)-10H-吩噻嗪-10-基]羰基]甘氨酸单钠盐 | 115871-18-6

• 物质功能分类: 有机原料 - 有机金属类化合物 - 有机钠
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: N-[[3,7-双(二甲基氨基)-10H-吩噻嗪-10-基]羰基]甘氨酸单钠盐
• 中文别名: 10-(羧甲基氨基羰基)-3,7-双(二甲氨基)吩噻嗪钠盐
• 英文名称: sodium salt of 10-(carboxymethylaminocarbonyl)-3,7-bis(dimethylamino)phenothiazine
• 英文别名: Sodium 2-(3,7-bis(dimethylamino)-10H-phenothiazine-10-carboxamido)acetate；sodium;2-[[3,7-bis(dimethylamino)phenothiazine-10-carbonyl]amino]acetate
• CAS: 115871-18-6
• 化学式: C₁₉H₂₁N₄O₃S*Na
• 分子量: 408.457
• InChiKey: CWLYDTVACYGEPD-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -1.12
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  104
• 氢给体数：
  1
• 氢受体数：
  6

安全信息

• 海关编码：
  29349990

反应信息

• 作为产物：
  描述：

  ethyl isocyanate acetate 、 亚甲兰 、 锌 在 盐酸 、 sodium hydroxide 作用下， 以 甲醇 、 水 为溶剂， 生成 N-[[3,7-双(二甲基氨基)-10H-吩噻嗪-10-基]羰基]甘氨酸单钠盐
  参考文献：
  名称：

  Urea derivatives and colorimetric determination using the same as chromogen

  摘要：

  公开号：

  EP0251297B1

文献信息

• Method of assaying bolld component by using whole blood and measurement kit
  申请人：Umegae Yoshihiki

  公开号：US20100075352A1

  公开（公告）日：2010-03-25

  [Problem] In quickly assaying a blood component interfered by glucose and/or its derivative on the bedside or in a clinic or in assaying the same by a patient in his/her own home, there has been required an assay method wherein the whole blood can be used as a sample as such without resorting to a centrifuge or the like. [Means For Solving Problems] A method of assaying a blood component to be used for assaying a blood component interfered by glucose and/or its derivative, characterized by comprising bringing the whole blood into contact with a substance capable of converting glucose and/or its derivative into another substance not interfering the assay and, simultaneously or subsequently, separating blood cells; a device to be used in the assay method; and a kit containing this device.

  【问题】在床边或诊所中快速检测被葡萄糖和/或其衍生物干扰的血液成分，或者在患者自己的家中进行检测，需要一种检测方法，可以使用全血作为样本，而不需要离心机或类似设备。【解决问题的方法】一种检测血液成分的方法，用于检测被葡萄糖和/或其衍生物干扰的血液成分，其特征在于将全血与能够将葡萄糖和/或其衍生物转化为不干扰检测的另一种物质接触，并同时或随后分离血细胞；用于该检测方法的设备；以及包含该设备的试剂盒。
• Measurement of LDL-cholesterol
  申请人：WAKO PURE CHEMICAL INDUSTRIES, LTD

  公开号：EP0878716A1

  公开（公告）日：1998-11-18

  Cholesterol in low density lipoproteins can be measured specifically and precisely using directly an autoanalyzer in the presence of an amphoteric surfactant and at least one member selected from cyclodextrin and derivatives thereof.

  低密度脂蛋白中的胆固醇可在两性表面活性剂和至少一种选自环糊精及其衍生物的成分存在下，直接使用自动分析仪进行特异性和精确的测量。
• Method for measuring LDL-cholesterol
  申请人：WAKO PURE CHEMICAL INDUSTRIES, LTD

  公开号：EP0964249A2

  公开（公告）日：1999-12-15

  The amount of cholesterol in low density lipoproteins in a sample can be measured by contacting the sample with one or more reagent solutions to carry out the reaction in the presence of a polyanion and an amphoteric surfactant, followed by optical measurement of the reaction product.

  将样品与一种或多种试剂溶液接触，在聚阴离子和两性表面活性剂的存在下进行反应，然后用光学方法测量反应产物，就可以测量样品中低密度脂蛋白的胆固醇含量。
• METHOD OF MEASURING TOTAL HOMOCYSTEINE
  申请人：Azwell Inc.

  公开号：EP1295947A1

  公开（公告）日：2003-03-26

  The present invention provides a method and a kit for detecting or quantitatively determining homocysteine rapidly and simply and with high sensitivity by oxidizing the residual homocysteine cosubstrate, the produced homocysteine-converting enzyme product or an enzyme reaction product thereof in the presence of an SH reagent to produce hydrogen peroxide and determining the produced hydrogen peroxide by color development using an oxidative color-developing agent. By using the method and kit of the present invention, homocysteine in biological samples, in particular, in body fluids such as blood and urine can be detected and quantitatively determined rapidly and simply and with high sensitivity.

  本发明提供了一种快速、简单和高灵敏度地检测或定量测定同型半胱氨酸的方法和试剂盒，其方法是在SH试剂存在下氧化残留的同型半胱氨酸共底物、生成的同型半胱氨酸转化酶产物或其酶反应产物以产生过氧化氢，并使用氧化显色剂通过显色测定生成的过氧化氢。通过使用本发明的方法和试剂盒，可以快速、简单、高灵敏度地检测和定量测定生物样品，特别是血液和尿液等体液中的同型半胱氨酸。
• METHOD OF ASSAY WITH SULFONIC ACID COMPOUND AND NITRO COMPOUND
  申请人：ARKRAY, Inc.

  公开号：EP1515144A1

  公开（公告）日：2005-03-16

  A method for measuring an analyte in a sample by using a redox reaction is provided, which gives values with excellent reliability. Prior to the redox reaction, at least one of a sulfonic acid compound and a nitro compound is added to the sample to eliminate the influence of hemoglobin and any hemoglobin degradation products as reducing substances contained in the sample. Subsequently, a reducing or oxidizing substance derived from the analyte is caused to generate, and the amount thereof is measured by the redox reaction. The amount of the analyte is determined from the measurement value. The sulfonic acid compound may be sodium lauryl sulfate, and the nitro compound may be 4-nitrophenol, etc.

  本发明提供了一种利用氧化还原反应测量样品中分析物的方法，其测量值非常可靠。在进行氧化还原反应之前，先将磺酸化合物和硝基化合物中的至少一种添加到样品中，以消除样品中含有的血红蛋白和任何血红蛋白降解产物作为还原性物质的影响。随后，使分析物产生还原性或氧化性物质，并通过氧化还原反应测量其含量。根据测量值确定被分析物的量。磺酸化合物可以是十二烷基硫酸钠，硝基化合物可以是 4-硝基苯酚等。