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4-羧基-2-氟苯硼酸 | 851335-07-4

中文名称
4-羧基-2-氟苯硼酸
中文别名
4-羧基-2-氟苯基硼酸;4-羟基-2-氟苯硼酸
英文名称
4-borono-3-fluorobenzoic acid
英文别名
2-fluoro-4-carboxyphenylboronic acid;4-carboxy-2-fluorobenzeneboronic acid
4-羧基-2-氟苯硼酸化学式
CAS
851335-07-4
化学式
C7H6BFO4
mdl
MFCD08458473
分子量
183.932
InChiKey
TVNVDRMGOOLVOX-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

物化性质

  • 沸点:
    402.6±55.0 °C(Predicted)
  • 密度:
    1.49±0.1 g/cm3(Predicted)

计算性质

  • 辛醇/水分配系数(LogP):
    1.3
  • 重原子数:
    13
  • 可旋转键数:
    2
  • 环数:
    1.0
  • sp3杂化的碳原子比例:
    0.0
  • 拓扑面积:
    77.8
  • 氢给体数:
    3
  • 氢受体数:
    5

安全信息

  • 危险品标志:
    Xi
  • 海关编码:
    2931900090
  • 危险性防范说明:
    P261,P305+P351+P338
  • 危险性描述:
    H315,H319,H335

SDS

SDS:560dc67aaac542168ca643db70cf85b6
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Material Safety Data Sheet

Section 1. Identification of the substance
4-Carboxy-2-fluorophenylboronic acid
Product Name:
Synonyms: 4-Borono-3-fluorobenzoic acid

Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.
H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
P261: Avoid breathing dust/fume/gas/mist/vapours/spray
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present
and easy to do – continue rinsing
P302+P352: IF ON SKIN: Wash with soap and water
P321: Specific treatment (see on this label)
P405: Store locked up

Section 3. Composition/information on ingredients.
4-Carboxy-2-fluorophenylboronic acid
Ingredient name:
CAS number: 851335-07-4

Section 4. First aid measures
Immediately wash skin with copious amounts of water for at least 15 minutes while removing
Skin contact:
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.
Ingestion:

Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Storage: Store in closed vessels.

Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section 9. Physical and chemical properties
Not specified
Appearance:
Boiling point: No data
Melting point: No data
Flash point: No data
Density: No data
Molecular formula: C7H6BFO4
Molecular weight: 183.9

Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, hydrogen fluoride.

Section 11. Toxicological information
No data.

Section 12. Ecological information
No data.

Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

Section 14. Transportation information
Non-harzardous for air and ground transportation.

Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.


SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

4-羧基-2-氟苯硼酸是一种用于医药中间体的化合物,可以参与Suzuki等金属偶联反应。据文献记载,它还可作为中间体用于制备WDR5蛋白-蛋白相互作用抑制剂和BTK抑制剂。

上下游信息

  • 上游原料
    中文名称 英文名称 CAS号 化学式 分子量
  • 下游产品
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

  • 作为反应物:
    描述:
    4-羧基-2-氟苯硼酸 在 magnesium sulfate 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺N,N-二异丙基乙胺 作用下, 以 四氢呋喃二氯甲烷N,N-二甲基甲酰胺 为溶剂, 生成 3,5-bis((3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamido)methyl)benzoic acid
    参考文献:
    名称:
    [EN] GLUCOSE SENSITIVE INSULIN DERIVATIVES
    [FR] DÉRIVÉS D'INSULINE SENSIBLES AU GLUCOSE
    摘要:
    公开号:
    WO2020201041A3
  • 作为产物:
    参考文献:
    名称:
    Ortho-substituted aryl monoboronic acids have improved selectivity for d-glucose relative to d-fructose and l-lactate
    摘要:
    Ortho-substituted aryl monoboronic acids have been found to have improved selectivity for D-glucose compared to D-fructose and L-lactate. These findings are supported by computational studies on the B3LYP/6-31G(d) level using Gaussian. This finding is of interest for development of boronate based D-glucose sensors. (C) 2010 Elsevier Ltd. All rights reserved.
    DOI:
    10.1016/j.tet.2010.11.062
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文献信息

  • RorgammaT inhibitors
    申请人:MSD Oss B.V.
    公开号:EP2487159A1
    公开(公告)日:2012-08-15
    The present invention relates to compounds according to general Formula I or a pharmaceutically acceptable salt thereof. Such compounds can be used in the treatment of RORgammaT-mediated diseases or conditions.
    本发明涉及符合一般式I的化合物 或其药用可接受的盐。这些化合物可用于治疗RORgammaT介导的疾病或症状。
  • NOVEL COMPOUNDS AS GPR119 AGONISTS
    申请人:Mankind Pharma Ltd.
    公开号:US20170291910A1
    公开(公告)日:2017-10-12
    The present invention relates to novel compounds of formula (I) as GPR119 agonist, composition compositions containing such compounds and method of preparation thereof.
    本发明涉及式(I)的新化合物作为GPR119激动剂,包含此类化合物的组合物及其制备方法。
  • [EN] RORGAMMAT INHIBITORS<br/>[FR] INHIBITEURS DE RORGAMMAT
    申请人:MERCK SHARP & DOHME
    公开号:WO2012106995A1
    公开(公告)日:2012-08-16
    The present invention relates to compounds according to Formula (I) or a pharmaceutically acceptable salt or solvate thereof. Such compounds can be used in the treatment of RORgammaT-mediated diseases or condition.
    本发明涉及按照式(I)的化合物或其药用可接受的盐或溶剂。这些化合物可用于治疗RORgammaT介导的疾病或症状。
  • C-3 benzoic acid derivatives of C-3 deoxybetulinic acid and deoxybetulin as HIV-1 maturation inhibitors
    作者:Zheng Liu、Jacob J. Swidorski、Beata Nowicka-Sans、Brian Terry、Tricia Protack、Zeyu Lin、Himadri Samanta、Sharon Zhang、Zhufang Li、Dawn D. Parker、Sandhya Rahematpura、Susan Jenkins、Brett R. Beno、Mark Krystal、Nicholas A. Meanwell、Ira B. Dicker、Alicia Regueiro-Ren
    DOI:10.1016/j.bmc.2016.03.001
    日期:2016.4
    A series of C-3 phenyl- and heterocycle-substituted derivatives of C-3 deoxybetulinic acid and C-3 deoxybetulin was designed and synthesized as HIV-1 maturation inhibitors (MIs) and evaluated for their antiviral activity and cytotoxicity in cell culture. A 4-subsituted benzoic acid moiety was identified as an advantageous replacement for the 3′3′-dimethylsuccinate moiety present in previously disclosed
    设计并合成了一系列C-3脱氧贝丁酸和C-3脱氧贝丁酸的C-3苯基和杂环取代衍生物,作为HIV-1成熟抑制剂(MIs),并评估了它们在细胞培养中的抗病毒活性和细胞毒性。鉴定出4-取代的苯甲酸部分是先前公开的MI中存在的3'3'-二甲基琥珀酸酯部分的有利替代物,其阐明了药效团的拓扑学的新方面。与原型HIV-1 MI bevirimat(1,BVM)相比,新的类似物对野生型(wt)病毒具有出色的体外抗病毒活性,并且血清转移降低,这是临床研究中第一个评估的MI。化合物9a对wt病毒表现出与1类似的细胞培养能力( 对于9a, WT EC 50 = 16 nM,而对于1a,则为10 nM )。但是,9a的效力受人血清的影响较小,而该化合物在大鼠中的药代动力学特征与1相似。因此,9a(脱氧贝丁酸的4-苯甲酸衍生物)代表了探索第二代MI设计的新起点。
  • [EN] NOVEL SUBSTITUTED BICYCLIC AROMATIC COMPOUNDS AS S-NITROSOGLUTATHIONE REDUCTASE INHIBITORS<br/>[FR] NOUVEAUX COMPOSÉS AROMATIQUES BICYCLIQUES SUBSTITUÉS EN TANT QU'INHIBITEURS DE LA S-NITROSOGLUTATHION RÉDUCTASE
    申请人:N30 PHARMACEUTICALS LLC
    公开号:WO2012083165A1
    公开(公告)日:2012-06-21
    The present invention is directed to novel substituted bicyclic aromatic compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors, pharmaceutical compositions comprising such compounds, and methods of making and using the same.
    本发明涉及一类新颖的取代双环芳族化合物,该化合物可用作S-硝基谷胱甘肽还原酶(GSNOR)的抑制剂,包括含有此类化合物的药物组合物,以及制造和使用这些化合物的方法。
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