SPF-3059-26

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异黄酮类化合物
• 英文名称: SPF-3059-26
• 英文别名: 2,4-Diacetyl-3-(6,7-dihydroxy-4-oxochromen-3-yl)-6,7-dihydroxyxanthen-9-one
• 化学式: C₂₆H₁₆O₁₀
• 分子量: 488.407
• InChiKey: BSHCAXARTZBKBH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  36
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  168
• 氢给体数：
  4
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  1,1'-(3-(6,7-bis(methoxymethoxy)-4-oxo-4H-chromen-3-yl)-6,7-bis(methoxymethoxy)-9-oxo-9H-xanthene-2,4-diyl)bis(ethan-1-one) 在 盐酸 作用下， 以 甲醇 为溶剂， 反应 8.0h， 以97%的产率得到SPF-3059-26
  参考文献：
  名称：

  [EN] ANALOGS OF VINAXANTHONE AND XANTHOFULVIN, METHODS OF SYNTHESIS, AND METHODS OF TREATMENTS THEREOF
  [FR] ANALOGUES DE VINAXANTHONE ET DE XANTHOFULVINE, LEURS PROCÉDÉS DE SYNTHÈSE, ET MÉTHODES THÉRAPEUTIQUES LES UTILISANT

  摘要：

  本发明通常涉及文安黄质和黄酮黄质的合成方法，新颖的类似物及其使用方法。

  公开号：

  WO2015021226A1

文献信息

• ANALOGS OF VINAXANTHONE AND XANTHOFULVIN, METHODS OF SYNTHESIS, AND METHODS OF TREATMENTS THEREOF
  申请人：BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

  公开号：US20160185745A1

  公开（公告）日：2016-06-30

  The present invention relates generally to methods of synthesis of vinaxanthone and xanthofulvin, novel analogs, and methods of use thereof.

  本发明涉及文纳黄酮和黄傅素的合成方法，新的类似物及其使用方法。
• Nerve regeneration promoters containing semaphorin inhibitor as the active ingredient
  申请人：Kimura Toru

  公开号：US20070015820A1

  公开（公告）日：2007-01-18

  To provide a semaphorin inhibitor; a peripheral or central nerve regeneration promoter which contains said semaphorin inhibitor as an active ingredient; and a preventive or remedy for a neuropathic disease and a neurodegenerative disease containing said nerve regeneration promoter, or the like. A low-molecular weight compound, which acts at a concentration of 10 μg/ml or below to inhibit the growth cone collapse activity of semaphorin such as semaphorin 3A, semaphorin 6C or the like and/or the nerve outgrowth inhibitory activity of semaphorin in a collagen gel and which does not substantially affect cell proliferation, is obtained from the culture of strain SPF-3059 belonging to the genus Penicillium. The low-molecular weight compound with the semaphorin inhibitory activity thus obtained exhibits the in vivo nerve-regeneration promoting action.
• THERAPEUTIC AGENT FOR CORNEAL SENSORY NERVE DAMAGE CONTAINING SEMAPHORIN INHIBITOR AS ACTIVE INGREDIENT
  申请人：Okano Hideyuki

  公开号：US20140018416A1

  公开（公告）日：2014-01-16

  A compound represented by formula (1), or a pharmaceutically acceptable salt thereof is effective as a therapeutic agent or a prophylactic agent for a corneal disease or sensory nerve damage due to corneal surgery, and as a regeneration accelerator for corneal sensory nerves: wherein R 1 represents a hydrogen atom or a carboxyl group, R 2 represents a hydrogen atom or a hydroxy group, R 3 represents a hydrogen atom or a carboxyl group, and R 4 represents a hydrogen atom or a hydroxy group.
• US7244761B2
  申请人：——

  公开号：US7244761B2

  公开（公告）日：2007-07-17
• US7317038B2
  申请人：——

  公开号：US7317038B2

  公开（公告）日：2008-01-08