4H-1-Benzopyran-4-one, 7-(beta-D-glucopyranosyloxy)-3-(4-hydroxyphenyl)-

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异黄酮类化合物
• 英文名称: 4H-1-Benzopyran-4-one, 7-(beta-D-glucopyranosyloxy)-3-(4-hydroxyphenyl)-
• 英文别名: 3-(4-hydroxyphenyl)-7-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one
• 化学式: C₂₁H₂₀O₉
• 分子量: 416.4
• InChiKey: KYQZWONCHDNPDP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  146
• 氢给体数：
  5
• 氢受体数：
  9

文献信息

• ALDH-2 INHIBITORS IN THE TREATMENT OF DRUG ADDICTION
  申请人：Zablocki Jeff

  公开号：US20080032995A1

  公开（公告）日：2008-02-07

  Disclosed are novel isoflavone derivatives having the structure of Formula I which are useful as ALDH-2 inhibitors for treating mammals for dependence upon drugs of addiction, for example addiction to dopamine-producing agent such as cocaine, morphine, amphetamines, nicotine, and alcohol.

  揭示了具有以下结构的新型异黄酮衍生物，其可用作ALDH-2抑制剂，用于治疗哺乳动物对成瘾药物的依赖，例如对多巴胺类药物如可卡因、吗啡、安非他命、尼古丁和酒精的依赖。
• [EN] ALDH-2 INHIBITORS IN THE TREATMENT OF ADDICTION<br/>[FR] INHIBITEURS D'ALDH-2 DANS LE TRAITEMENT D'UNE ACCOUTUMANCE
  申请人：CV THERAPEUTICS INC

  公开号：WO2009094028A1

  公开（公告）日：2009-07-30

  Disclosed are novel isoflavone derivatives having the structure of Formula I which are useful as ALDH-2 inhibitors for treating mammals for dependence upon drugs of addiction, for example addiction to dopamine-producing agent such as cocaine, morphine, amphetamines, nicotine, and alcohol.

  揭示了具有Formula I结构的新型异黄酮衍生物，可用作ALDH-2抑制剂，用于治疗哺乳动物对成瘾药物的依赖，例如对多巴胺类药物如可卡因、吗啡、安非他命、尼古丁和酒精的依赖。
• ALDH-2 INHIBITORS IN THE TREATMENT OF ADDICTION
  申请人：Zablocki Jeff

  公开号：US20080207610A1

  公开（公告）日：2008-08-28

  Disclosed are novel isoflavone derivatives having the structure of Formula I which are useful as ALDH-2 inhibitors for treating mammals for dependence upon drugs of addiction, for example addiction to dopamine-producing agent such as cocaine, morphine, amphetamines, nicotine, and alcohol.

  本发明揭示了一种新型异黄酮衍生物，其具有I式结构，可用作ALDH-2抑制剂，用于治疗哺乳动物对成瘾药物的依赖，例如对多巴胺产生剂如可卡因、吗啡、安非他命、尼古丁和酒精的成瘾。
• QUINAZOLINONE DERIVATIVES AS ALDH-2 INHIBITORS
  申请人：Zablocki Jeff

  公开号：US20080249116A1

  公开（公告）日：2008-10-09

  Disclosed are novel quinazolinone derivatives, useful as ALDH-2 inhibitors for treating mammals for various disease states, such as treatment for cocaine dependency or alcohol dependency.

  本发明涉及一种新型的喹唑啉酮衍生物，可用作ALDH-2抑制剂，用于治疗哺乳动物的各种疾病状态，如治疗可卡因依赖症或酒精依赖症。
• Bean leaves or bean stems having high isoflavone derivatives content and method for preparing same
  申请人：INDUSTRY-ACADEMIC COOPERATION FOUNDATION GYEONGSANG NATIONAL UNIVERSITY

  公开号：US10183050B2

  公开（公告）日：2019-01-22

  The present invention relates to soybean leaves or soybean stems having high isoflavone derivative content, and a method for preparing the same. Specifically, by finding that soybean leaves or soybean stems treated with ethylene and ethephon, i.e. a ethylene donor, show significantly increased isoflavone derivative content, the method for preparing the soybean leaves or soybean stems having high isoflavone derivative content and the soybean leaves or soybean stems having high isoflavone derivative content prepared by using the method can be useful as functional foods and medicinal materials for diseases due to estrogen imbalance and lack of the antioxidative activity.

  本发明涉及异黄酮衍生物含量高的大豆叶或大豆茎，以及制备方法。具体而言，通过发现用乙烯和乙烯利（即乙烯供体）处理的大豆叶或大豆茎的异黄酮衍生物含量显著增加，制备具有高异黄酮衍生物含量的大豆叶或大豆茎的方法以及用该方法制备的具有高异黄酮衍生物含量的大豆叶或大豆茎可作为功能性食品和药用材料，用于治疗因雌激素失衡和缺乏抗氧化活性而导致的疾病。