pisatin | 412300-69-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异黄酮类化合物
• 英文名称: pisatin
• 英文别名: 16-methoxy-5,7,11,19-tetraoxapentacyclo[10.8.0.02,10.04,8.013,18]icosa-2,4(8),9,13(18),14,16-hexaen-1-ol
• CAS: 412300-69-7
• 化学式: C₁₇H₁₄O₆
• 分子量: 314.295
• InChiKey: LZMRDTLRSDRUSU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  66.4
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• METHODS FOR SYNTHESIZING GLYCINOLS, GLYCEOLLINS I AND II, COMPOSITIONS OF SELECTED INTERMEDIATES, AND THERAPEUTIC USES THEREOF
  申请人：Erhardt Paul W.

  公开号：US20110144195A1

  公开（公告）日：2011-06-16

  Two distinct methods are disclosed and claimed for synthesizing glyceollin I plus glyceollin II as a mixture and as their pure forms. Stereochemical isomers and various synthetic intermediates are also synthesized and claimed for their novel compositions of matter. All compounds and their mixtures are claimed for use in formulations that are useful to treat or prevent cancer, or that have utility as selective estrogen receptor modulators, such formulations including enhanced or medical foods, dietary supplements and ethical pharmaceutical agents.

  公开并声明了两种不同的方法，用于合成甘油素I和甘油素II，作为混合物和其纯形式。立体化学异构体和各种合成中间体也被合成并声明为其新颖的物质组成。所有化合物及其混合物均声明用于制剂，用于治疗或预防癌症，或具有作为选择性雌激素受体调节剂的效用，这些制剂包括增强食品、膳食补充剂和伦理药物代理。
• [EN] BIOLOGICAL FERMENTATION USING DIHYDROXYACETONE AS A SOURCE OF CARBON<br/>[FR] FERMENTATION BIOLOGIQUE UTILISANT DE LA DIHYDROXYACÉTONE COMME SOURCE DE CARBONE
  申请人：KEMBIOTIX LLC

  公开号：WO2017139420A1

  公开（公告）日：2017-08-17

  The present invention relates to the use of hydrocarbons derived from natural gas in the fermentative production of biochemicals including biofuels. More specifically, the present invention provides the method for manufacturing dihydroxyacetone ("DHA") from natural gas, biogas, biomass and CO2 released from industrial plants including electricity-generating plants, steel mills and cement factories and the use of DHA as a source of organic carbon in the fermentative production of biochemicals including biofuels. The present invention comprises three stages. In the first stage of the present invention, syngas and formaldehyde are produced from natural gas, biogas, biomass and CO2 released from industrial plants. In the second stage of the present invention, formaldehyde and syngas are condensed to produce DHA. In the third stage of the present invention, biochemicals including biofuels are produced from DHA using fermentation process involving wild type or genetically modified microbial biocatalysts.

  本发明涉及使用从天然气中提取的碳氢化合物在生物化学品，包括生物燃料的发酵生产中的应用。更具体地说，本发明提供了一种从天然气、沼气、生物质和工业厂房中释放的CO2中制造二羟基丙酮（"DHA"）的方法，以及将DHA作为有机碳源在发酵生产中制造生物化学品，包括生物燃料的应用。本发明包括三个阶段。在本发明的第一阶段中，从天然气、沼气、生物质和工业厂房中释放的CO2中产生合成气和甲醛。在本发明的第二阶段中，甲醛和合成气被凝结成DHA。在本发明的第三阶段中，使用野生型或基因改造的微生物生物催化剂进行发酵过程，从DHA中生产生物化学品，包括生物燃料。
• Agent for treating eye diseases
  申请人：Okamoto Shinseiro

  公开号：US20060111318A1

  公开（公告）日：2006-05-25

  An agent for treating various kinds of diseases which contains at least one selected from the group consisting of sexual steroid hormone such as estrogen or its metabolites, its derivative, structural analogues thereof, estrogen acting substance or SERM non-feminizing estrogen (non-hormonal estrogen), and an activator of sirtuin and has a form of eye drops or eye washes, oral preparation, etc. An agent for treating eye diseases which has excellent treatment effects, reduced in side action can be provided.

  一种治疗各种疾病的药剂，其中包含至少一种从以下组合中选择的物质：性激素类固醇激素，如雌激素或其代谢产物，其衍生物，结构类似物，雌激素作用物质或SERM非女性化雌激素（非激素雌激素），以及一种激活sirtuin的物质，并且该药剂形式为眼药水或眼洗液，口服制剂等。可以提供具有出色治疗效果、副作用减少的治疗眼疾的药剂。
• Plant isoflavonoid hydroxylases and methods of use thereof
  申请人：Dixon A. Richard

  公开号：US20050172354A1

  公开（公告）日：2005-08-04

  The invention provides plant isoflavonoid hydroxylase coding sequences. Also provided are constructs comprising these sequences, plants transformed therewith and methods of use thereof. In certain aspects of the invention, plants transformed with the nucleic acids are provided exhibiting improved pest and disease resistance. Plants provided by the invention may also exhibit improved nutritional qualities.

  本发明提供了植物异黄酮羟化酶编码序列。还提供了包含这些序列的构建物、转化有这些构建物的植物以及使用方法。在本发明的某些方面，提供了通过核酸转化而获得改善害虫和疾病抗性的植物。本发明提供的植物也可能表现出改善的营养品质。
• PLANT ISOFLAVONOID HYDROXYLASES AND METHODS OF USE THEREOF
  申请人：Dixon Richard A.

  公开号：US20090142471A1

  公开（公告）日：2009-06-04

  The invention provides plant isoflavonoid hydroxylase coding sequences. Also provided are constructs comprising these sequences, plants transformed therewith and methods of use thereof. In certain aspects of the invention, plants transformed with the nucleic acids are provided exhibiting improved pest and disease resistance. Plants provided by the invention may also exhibit improved nutritional qualities.

  本发明提供植物异黄酮羟化酶编码序列。还提供含有这些序列的构建物，以及转化有这些构建物的植物和使用方法。在本发明的某些方面中，提供了转化了核酸的植物，这些植物表现出改善的害虫和疾病抗性。本发明提供的植物也可能表现出改善的营养特性。