6-Ethoxy-3-(4-hydroxyphenyl)-4-methylchromen-2-one | 331821-45-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异黄酮类化合物
• 英文名称: 6-Ethoxy-3-(4-hydroxyphenyl)-4-methylchromen-2-one
• CAS: 331821-45-5
• 化学式: C₁₈H₁₆O₄
• 分子量: 296.3
• InChiKey: MOBDZHABRVPJCH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Compounds exhibiting efflux inhibitor activity and composition and uses thereof
  申请人：Wempe Fitzpatrick Michael

  公开号：US20070254859A1

  公开（公告）日：2007-11-01

  At least one compound chosen from compounds of Formula I: a pharmaceutically acceptable salt or ester thereof, a solvate thereof, a chelate thereof, a non-covalent complex thereof, a prodrug thereof, and mixtures of any of the foregoing, wherein: n is a number from 1 to 900, wherein the individual units may be the same or different; W is chosen from alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, aralkyl and substituted aralkyl; each of R 2 , R 3 , R 4 and R 5 is independently chosen from —H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, aralkyl and substituted aralkyl; Z′ is chosen from —O—, —N—, —NO—, —NR 4 —, —S—, —SO— and —SO 2 —, wherein R 4 is defined as above; each of X, X′, Y and Z is independently chosen from —CR 4 R 5 —, —NH—, —NR 4 —, —NO—, —O—, —NOR 4 —, —S—, —SO—, —SO 2 —, wherein R 4 and R 5 are defined as above; R 1 is chosen from a tocopherol, a steroid and a flavonoid; and R 6 is chosen from any R 1 , alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, aralkyl and substituted aralkyl.
• [EN] IDENTIFICATION OF COMPOUNDS THAT PROTECT AGAINST AMYLOID DISEASES<br/>[FR] IDENTIFICATION DE COMPOSÉS POUR LA PROTECTION CONTRE LES AMYLOSES
  申请人：SALK INST FOR BIOLOGICAL STUDI

  公开号：WO2008141074A1

  公开（公告）日：2008-11-20

  [EN] Compositions and methods for inhibiting protein aggregation and aggregation- mediated proteotoxicity are provided. Compositions include at least one of a flavone, a biguanide, a furanoflavonoid, 5-Aminoimidazole-4-carboxamide 1-ß-D- ribofuranoside, trimethadione, morin, and combinations thereof. The compositions can be used in conjunction with other compounds known to inhibit protein aggregation to enhance their activities. The invention further provides methods for identifying compounds that inhibit protein aggregation. The methods include the expression of a ß-amyloid peptide and determining the effect of a test compound on paralysis and/or protein aggregation.
  [FR] La présente invention concerne des compositions et des méthodes pour l'inhibition de l'agrégation des protéines et de la toxicité générée par cette agrégation. Les compositions comprennent une ou plusieurs flavone, biguanide, flavonoïde, 5-aminoimidazole-4-carboxamide 1-ß-D- ribofuranoside, triméthadione, morine, et des combinaisons desdits. Les compositions peuvent être utilisées en association avec d'autres composés connus pour leur inhibition de l'agrégation des protéines, ce qui permettra d'améliorer leur activité. L'invention fournit également des méthodes pour l'identification des composés inhibant l'agrégation des protéines. Les méthodes comprennent l'expression d'un peptide ß-amyloïde, et la détermination de l'effet d'un composé test sur la paralysie et/ou l'agrégation de protéines.