7,8-dihydro-8-hydroxypalmatine | 221527-72-6

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 原小檗碱生物碱及其衍生物
• 英文名称: 7,8-dihydro-8-hydroxypalmatine
• 英文别名: 8-hydroxy-7,8-dihydropalmatine；8-hydroxydihydropalmatine；2,3,9,10-tetramethoxy-6,8-dihydro-5H-isoquinolino[2,1-b]isoquinolin-8-ol
• CAS: 221527-72-6
• 化学式: C₂₁H₂₃NO₅
• 分子量: 369.417
• InChiKey: XQCLUPWMBVLJKO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  60.4
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  7,8-dihydro-8-hydroxypalmatine 在 sodium hydroxide 作用下， 以 乙醇 、 氯仿 、 水 为溶剂， 反应 4.0h， 以20%的产率得到黄藤素
  参考文献：
  名称：

  A 7,8-dihydro-8-hydroxypalmatine from Enantia chlorantha

  摘要：

  7,8-dihydro-8-hydroxypalmatine, a novel protoberberine type alkaloid, along with palmatine, has been isolated and characterized from an anti-HIV active extract from Enantia chlorantha. The structures of the two compounds were elucidated by spectroscopic analyses and from chemical evidence. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0031-9422(98)00382-3
• 作为产物：
  描述：

  黄藤素 在 sodium hydroxide 作用下， 以 乙醇 、 氯仿 为溶剂， 反应 4.0h， 以73%的产率得到7,8-dihydro-8-hydroxypalmatine
  参考文献：
  名称：

  Nyasse, Barthelemy; Nkwengoua; Sondengam, Pharmazie, 2002, vol. 57, # 6, p. 358 - 361

  摘要：

  DOI：

文献信息

• <i>In vitro</i>inhibitory effects of palmatine from<i>Enantia chlorantha</i>on<i>Trypanosoma cruzi</i>and<i>Leishmania infantum</i>
  作者：Ernestine Tchouboun Nkwengoua、Igor Ngantchou、Barthélemy Nyasse、Colette Denier、Casimir Blonski、Bernd Schneider

  DOI：10.1080/14786410902726241

  日期：2009.8.15

  In an attempt to establish the components responsible for the use of Enantia chlorantha against cutaneous leishmaniasis in local traditional medicine, a well-known palmatine has been isolated in substantial amounts from a methanolic bark extract of this plant species. Palmatine therein obtained exhibited a significant inhibitory activity on growth of both Trypanosoma cruzi (IC50 0.068 mu M) and Leishmania infantum (IC50 0.79 mu M).
• Nyasse, Barthelemy; Nkwengoua; Sondengam, Pharmazie, 2002, vol. 57, # 6, p. 358 - 361
  作者：Nyasse, Barthelemy、Nkwengoua、Sondengam、Denier、Willson

  DOI：——

  日期：——
• A 7,8-dihydro-8-hydroxypalmatine from Enantia chlorantha
  作者：Pascal Wafo、Barthelemy Nyasse、Catherine Fontaine

  DOI：10.1016/s0031-9422(98)00382-3

  日期：1999.1

  7,8-dihydro-8-hydroxypalmatine, a novel protoberberine type alkaloid, along with palmatine, has been isolated and characterized from an anti-HIV active extract from Enantia chlorantha. The structures of the two compounds were elucidated by spectroscopic analyses and from chemical evidence. (C) 1998 Elsevier Science Ltd. All rights reserved.