3-hydroxymethylcamphor | 20618-41-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 3-hydroxymethylcamphor
• 英文别名: (R,S)-3-(hydroxymethylene)-1,7,7-trimethylbicyclo<2.2.1>heptan-2-one；3-Hydroxymethyl-campher；DL-3-Hydroxymethyl-campher；3-(1-hydroxymethyl)-camphor；3-hydroxymethyl-1,7,7-trimethyl-norbornan-2-one；3-Hydroxymethyl-1,7,7-trimethyl-norbornan-2-on；3-(Hydroxymethyl)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one
• CAS: 20618-41-1
• 化学式: C₁₁H₁₈O₂
• 分子量: 182.263
• InChiKey: YWQRRMNZXWQQJU-UHFFFAOYSA-N

物化性质

• 溶解度：
  0.61 M

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-hydroxymethylcamphor 在 三氯化铁 作用下， 生成 3-氯樟脑-2-酮
  参考文献：
  名称：

  Rupe; Schaerer, Helvetica Chimica Acta, 1923, vol. 6, p. 1076

  摘要：

  DOI：
• 作为产物：
  描述：

  樟脑 在 镍 氢气 作用下， 以 乙醇 为溶剂， 生成 3-hydroxymethylcamphor
  参考文献：
  名称：

  Dallacker,F. et al., Justus Liebigs Annalen der Chemie, 1961, vol. 647, p. 23 - 36

  摘要：

  DOI：

文献信息

• Noxious-insect repellent
  申请人：Kanebo, Ltd.

  公开号：US20040091515A1

  公开（公告）日：2004-05-13

  Disclosed is a method of repelling noxious insects comprising the step of exposing said noxious insects to a composition containing from 0.1 to 90 wt. %, based on the total weight of the composition, of at least one of 2-(1-hydroxyalkyl)cycloalkanones represented by the following formula 11: 1 wherein n is an integer of 3-10, R 1 is hydrogen or a straight-chain saturated hydrocarbon radical having 1-6 carbon atoms; R 2 is hydrogen or methyl group and R m ′ represents m′ of the same or different, straight-chain or branched, saturated or unsaturated, hydrocarbon radicals R which, as a substituent group, can be bonded to carbocyclic atoms; m′ is an integer of 0-8, provided that m′ should be at least 2 when n is at least 4 and both the R 1 and R 2 are alkyl groups; the sum of the carbon atoms of R m ′ does not exceed 12; and, further, when n is 4, R may be an isopropylidene group which intramolecularly bridges between the third and sixth carbocyclic atoms.

  本发明涉及一种驱除有害昆虫的方法，其步骤包括将所述有害昆虫暴露于含有以下化合物之一的组成物中，所述化合物占组成物总重量的0.1至90重量％：2-（1-羟基烷基）环烷酮，其化学式为11:1，其中n为3-10的整数，R1为氢或具有1-6个碳原子的直链饱和碳氢基团，R2为氢或甲基基团，Rm'代表相同或不同的m'，直链或支链，饱和或不饱和，碳氢基团R，作为取代基团，可以与环状碳原子结合；m'为0-8的整数，但当n至少为4且R1和R2均为烷基时，m'应至少为2；Rm'的碳原子总数不超过12；当n为4时，R可以是一个异丙亚甲基基团，其在第三个和第六个环状碳原子之间形成分子内桥接。
• Staudinger; Kon, Justus Liebigs Annalen der Chemie, 1911, vol. 384, p. 88
  作者：Staudinger、Kon

  DOI：——

  日期：——
• Hope; Robinson, Journal of the Chemical Society, 1914, vol. 105, p. 2091
  作者：Hope、Robinson

  DOI：——

  日期：——
• Die katalytische Reduktion des Isobutylcyanides und des ?-Cyancamphers
  作者：H. Rupe、E. Hodel

  DOI：10.1002/hlca.192400701129

  日期：——
• Age-Related Decreases in Lymphocyte Protein Kinase C Activity and Translocation Are Reduced by Aerobic Fitness
  作者：H.-Y. Wang、T. R. Bashore、Z. V. Tran、E. Friedman

  DOI：10.1093/gerona/55.11.b545

  日期：2000.11.1

  This study investigated the effects of advancing age and long-term aerobic fitness on lymphocyte protein kinase C (PKC) activity and translocation. Lymphocytes were obtained from young (20-36 years old) and older (61-78 years old) healthy men who were either aerobically conditioned or deconditioned. Both baseline PKC activity and the response of this enzyme to the direct PKC stimulating agent, phorbol 12-myristate, 13-acetate (PMA) or to the mitogen, phytohaemagglutinin (PNA), were measured in partially purified extracts of cytosolic and membranous fractions of lymphocytes. Basal PKC activity, PMA-induced redistribution of PKC, and PHA-induced enhancement of PKC activity were reduced among older subjects in both lymphocyte cytosolic and membranous fractions. However, the magnitudes of these reductions were smaller among the older subjects who were aerobically fit. Lymphocyte PKC activity and translocation may be biological markers of aging, and the maintenance of aerobic fitness into later life mag. serve to slow the rate at which activation of this enzyme declines during senescence.