N-[2-oxo-2-(3-methoxyphenyl)ethyl]acetamide | 35746-82-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-[2-oxo-2-(3-methoxyphenyl)ethyl]acetamide
• 英文别名: N-2-[2-(3-methoxy-phenyl)-2-oxo-ethyl]acetamide；N-[2-(3-methoxyphenyl)-2-oxoethyl]acetamide
• CAS: 35746-82-8
• 化学式: C₁₁H₁₃NO₃
• 分子量: 207.229
• InChiKey: INYBPVAKEDUXKX-UHFFFAOYSA-N

物化性质

• 沸点：
  422.0±25.0 °C(Predicted)
• 密度：
  1.126±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-[2-oxo-2-(3-methoxyphenyl)ethyl]acetamide 在 sodium ethanolate 作用下， 以 乙醇 为溶剂， 生成 5-(3-Methoxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl-amine
  参考文献：
  名称：

  7-Alkyl- and 7-Cycloalkyl-5-aryl-pyrrolo[2,3-d]pyrimidines—potent inhibitors of the tyrosine kinase c-Src

  摘要：

  7-Substituted-5-aryl-pyrrolo[2,3-d]pyrimidines have been prepared starting from alpha -bromoacetophenones. These compounds represent a novel class of potent inhibitors of the tyrosine kinase pp60(c-Src) with good specificity towards other tyrosine kinases (EGF-R, v-Abl). (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00079-8
• 作为产物：
  描述：

  2-azido-1-(3-methoxyphenyl)ethanone 在 platinum on activated charcoal 盐酸 、 氢气 、 三乙胺 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 生成 N-[2-oxo-2-(3-methoxyphenyl)ethyl]acetamide
  参考文献：
  名称：

  7-Alkyl- and 7-Cycloalkyl-5-aryl-pyrrolo[2,3-d]pyrimidines—potent inhibitors of the tyrosine kinase c-Src

  摘要：

  7-Substituted-5-aryl-pyrrolo[2,3-d]pyrimidines have been prepared starting from alpha -bromoacetophenones. These compounds represent a novel class of potent inhibitors of the tyrosine kinase pp60(c-Src) with good specificity towards other tyrosine kinases (EGF-R, v-Abl). (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00079-8

文献信息

• N-7-heterocyclyl pyrrolo[2,3-D]pyrimidines and the use thereof
  申请人：Novartis AG

  公开号：US06051577A1

  公开（公告）日：2000-04-18

  There are described pyrrolo[2,3]pyrimidines of formula I ##STR1## wherein R.sub.1 -R.sub.5, m and n are as defined in the description. The compounds have valuable pharmaceutical properties and are effective especially as tyrosine protein kinase inhibitors. They can be used in the treatment of bone diseases and other diseases in warm-blooded animals that can be favorably influenced by the inhibition of tyrosine protein kinase.

  描述了化学式I的吡咯并[2,3]嘧啶，其中R.sub.1 -R.sub.5，m和n如描述中所定义。这些化合物具有有价值的药理特性，尤其作为酪氨酸蛋白激酶抑制剂效果显著。它们可用于治疗骨疾病和其他受酪氨酸蛋白激酶抑制有利影响的温血动物的疾病。
• Potassium-Base-Mediated Autoxidative Diastereoselective Homocoupling of <i>N</i>-Acyl-2-aminoacetophenones
  作者：Yingwei Wang、Mingrong Yang、Chichou Lao、Zhihong Jiang

  DOI：10.1021/acs.orglett.2c00618

  日期：2022.4.15

  general and highly efficient method for the synthesis of dl-2,3-diamide-1,4-diones via autoxidative dehydrogenative homocoupling of N-acyl-2-aminoacetophenones mediated by t-BuOK. The transformation is mild, operationally simple, and environmentally friendly. Control experiments and stereochemical results suggest that the substrate undergoes autoxidation followed by a diastereoselective SN2 reactopm.

  我们在此报告了一种通用且高效的方法，用于通过由t -BuOK 介导的N-酰基-2-氨基苯乙酮的自氧化脱氢同源偶联来合成dl -2,3-diamide-1,4- diones。改造温和、操作简单、环保。对照实验和立体化学结果表明，底物发生自氧化，然后发生非对映选择性 S N 2 反应。
• Oxidative Cross-Coupling of α-Amino Ketones with Alcohols Enabled by I₂-Catalyzed C–H Hydroxylation
  作者：Yingwei Wang、Mingrong Yang、Chichou Lao、Hanxuan Wang、Zhihong Jiang

  DOI：10.1021/acs.joc.3c01469

  日期：2023.10.20

  oxidative cross-coupling of α-amino ketones with a wide range of alcohols is described. Using a combination of air and dimethyl sulfoxide (DMSO) as oxidants, the protocol allows an efficient synthesis of α-carbonyl N,O-acetals with high functional group tolerance and enables the late-stage introduction of α-amino ketones into biorelevant alcohols. Moreover, the present method can be used in the coupling of

  描述了α-氨基酮与多种醇的I 2催化氧化交叉偶联。该方案使用空气和二甲基亚砜（DMSO）的组合作为氧化剂，可以有效合成具有高官能团耐受性的α-羰基N,O-缩醛，并能够在后期将α-氨基酮引入生物相关醇中。此外，该方法可用于α-氨基酮与其他种类的亲核试剂的偶联，这对于α-氨基酮的官能化具有很大的通用性。初步的机理研究表明，α-氨基酮的 C-H 羟基化已被认为是随后脱水偶联的关键步骤。
• Visible-light-induced Ritter-type amidation of α-hydroxy ketones in the selective synthesis of α,α-diamido and monoamido ketones
  作者：Enrong Tang、Quan-Quan Zhou、Jie-Ping Wan

  DOI：10.1039/d4cc02334j

  日期：——

  Visible light-induced, transition metal-free oxidative dehydroxylation and C–H amidation of α-hydroxy ketones involving Ritter-type amidation has been developed, leading to the selective synthesis of α,α-diamido- and α-monoamido ketones with tunable selectivity as well as broad substrate tolerance.

  开发了可见光诱导、无过渡金属的氧化脱羟基和涉及 Ritter 型酰胺化的 α-羟基酮的 C-H 酰胺化，从而可以选择性合成具有可调选择性的 α,α-二酰胺基和 α-单酰胺基酮以及广泛的基材耐受性。
• UMEZAWA, HAMAO;AOYAGI, TAKAAKI;SHIRAI, TADASHI;NISHIZAWA, RINZO;SUZUKI, M+
  作者：UMEZAWA, HAMAO、AOYAGI, TAKAAKI、SHIRAI, TADASHI、NISHIZAWA, RINZO、SUZUKI, M+

  DOI：——

  日期：——