3β-hydroxyurs-9(11),12-dien-28-oic acid | 90663-06-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 3β-hydroxyurs-9(11),12-dien-28-oic acid
• 英文别名: loxanic acid；3β-hydroxy-ursadien-(9(11).12)-oic acid-(28)；3β-Hydroxy-ursadien-(9(11).12)-saeure-(28)；3β-hydroxy-ursa-9(11),12-dien-28-oic acid；(1S,2R,4aS,6aR,6bS,8aR,10S,12aS,14bS)-10-hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-4a-carboxylic acid
• CAS: 90663-06-2
• 化学式: C₃₀H₄₆O₃
• 分子量: 454.693
• InChiKey: HYNNDRNHLBWNJU-IMNNGWJSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  33
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3β-hydroxyurs-9(11),12-dien-28-oic acid 、 乙酸酐 在 sodium acetate 作用下， 生成 3β-acetoxy-ursadien-(9(11).12)-oic acid-(28)
  参考文献：
  名称：

  An ocular cat-scratch disease patient positive for cytoplasmic anti-neutrophil cytoplasmic antibody

  摘要：

  Background: We report a case of ocular cat-scratch disease with permanent vision reduction in a patient who was cytoplasmic antineutrophil cytoplasmic antibody (C-ANCA) positive. Methods: Case report and review of the literature. Results: While taking steroids and antibiotics, a 52-year-old man with uveitis associated with cat-scratch disease developed retinal vein occlusion and a macular exudate. His final visual acuity was poor because of residual macular degeneration and optic atrophy. Serum C-ANCA increased and decreased in parallel with ocular inflammatory activity. Conclusion: C-ANCA is an indicator of vasculitis and may be useful as an indicator of severe cat-scratch disease.

  DOI：

  10.1007/s004170100374
• 作为产物：
  描述：

  methyl 3β-acetyloxy-11-oxo-urs-12-en-28-oate 在 氢氧化钾 、 sodium hydroxide 、 乙醇 、 sodium 作用下， 生成 3β-hydroxyurs-9(11),12-dien-28-oic acid
  参考文献：
  名称：

  An ocular cat-scratch disease patient positive for cytoplasmic anti-neutrophil cytoplasmic antibody

  摘要：

  Background: We report a case of ocular cat-scratch disease with permanent vision reduction in a patient who was cytoplasmic antineutrophil cytoplasmic antibody (C-ANCA) positive. Methods: Case report and review of the literature. Results: While taking steroids and antibiotics, a 52-year-old man with uveitis associated with cat-scratch disease developed retinal vein occlusion and a macular exudate. His final visual acuity was poor because of residual macular degeneration and optic atrophy. Serum C-ANCA increased and decreased in parallel with ocular inflammatory activity. Conclusion: C-ANCA is an indicator of vasculitis and may be useful as an indicator of severe cat-scratch disease.

  DOI：

  10.1007/s004170100374

文献信息

• Auxiliary-directed oxidation of ursolic acid by ‘Ru’-porphyrins: chemical modulation of cytotoxicity against tumor cell lines
  作者：Katsunori Tanaka、Kishor Mazumder、Eric R.O. Siwu、Satoshi Nozaki、Yasuyoshi Watanabe、Koichi Fukase

  DOI：10.1016/j.tetlet.2012.01.107

  日期：2012.4

  Derivatization of ursolic acid, one of the natural ursene-type pentacyclic triterpenes, was investigated by the oxidation with dioxoruthenium(VI) tetraphenylporphyrins. Oxidation selectivity on the terpene structure was modulated by the auxiliaries introduced on the tetraphenylporphyrin. Chemical oxidation of the ursolic acid affected the cytotoxic activity against tumor cell lines.

  熊果酸（一种天然的熊果型五环三萜烯）的衍生化是通过用二氧合钌（VI）四苯基卟啉进行氧化研究的。通过在四苯基卟啉上引入的助剂调节萜​​烯结构上的氧化选择性。熊果酸的化学氧化影响了针对肿瘤细胞系的细胞毒性活性。
• Pharmaceutically active ursolic acid derivative
  申请人：I.S.F. Spa

  公开号：US04530934A1

  公开（公告）日：1985-07-23

  There are described a new pharmaceutically active derivative of ursolic acid, 3.beta.-(3-carboxypropionyloxy)ursa-9(11),12-dien-28-oic acid, which possesses activity as an anti-ulcer and anti-viral agent, pharmaceutically acceptable, non-toxic salts thereof, a method of preparing the same and compositions containing the same.

  描述了一种新的药理活性衍生物，即3-β-(3-羧基丙酰氧基)乌药酸-9(11),12-二烯-28-酸，具有抗溃疡和抗病毒活性，其药学上可接受，非毒性盐，以及制备该衍生物的方法和含有该衍生物的组合物。
• Zur Kenntnis der Triterpene. (78. Mitteilung). Einf�hrung zus�tzlicher Doppelbindungen beim ?- und ?-Amyrin-Typus mit N-Brom-succinimid
  作者：L. Ruzicka、O. Jeger、J. Redel

  DOI：10.1002/hlca.19430260426

  日期：1943.6.15
• US4530934A
  申请人：——

  公开号：US4530934A

  公开（公告）日：1985-07-23
• An ocular cat-scratch disease patient positive for cytoplasmic anti-neutrophil cytoplasmic antibody
  作者：Harumi Fukushima、Jiro Numaga、Miwako Yoshimoto、Satoshi Kato、Hidetoshi Kawashima

  DOI：10.1007/s004170100374

  日期：2001.11

  Background: We report a case of ocular cat-scratch disease with permanent vision reduction in a patient who was cytoplasmic antineutrophil cytoplasmic antibody (C-ANCA) positive. Methods: Case report and review of the literature. Results: While taking steroids and antibiotics, a 52-year-old man with uveitis associated with cat-scratch disease developed retinal vein occlusion and a macular exudate. His final visual acuity was poor because of residual macular degeneration and optic atrophy. Serum C-ANCA increased and decreased in parallel with ocular inflammatory activity. Conclusion: C-ANCA is an indicator of vasculitis and may be useful as an indicator of severe cat-scratch disease.